鲍曼不动杆菌产OXA-23和AmpC酶的Meta分析
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摘要
目的比较全国8个省市鲍曼不动杆菌产OXA-23、AmpC酶情况,并分析其耐药机制。方法搜集国内关于鲍曼不动杆菌耐药机制的研究报道,采用Meta分析的方法对产OXA-23、AmpC酶情况进行综合分析。结果收集8个省市的鲍曼不动杆菌产OXA-23、AmpC酶的相关文献,两种酶总体检出率比较,差异无统计学意义(χ2=0.1183,P=0.7309);但各地区间存在一定差异,上海、江苏以产OXA-23为主,浙江、广东、重庆以产AmpC酶为主。结论全国鲍曼不动杆菌产OXA-23、AmpC酶一致,但不同地区间存在一定差异。
Objective To compare the OXA-23 and AmpC enzyme produced by Acinetobacter baumannii in 8 provinces, so as to analyze the resistance mechanism. Methods The reports on the resistance mechanism of Acinetobacter baumannii were comprehensively gathered, and the information of producing OXA-23, AmpC enzyme was made a full analysis by Meta analysis method. Results Pertinent literature in 8 provinces was collected. There was no significant difference in producing OXA-23 and AmpC enzyme in general(χ2=0.1183, P=0.7309); However, the differences among different regions were present. The OXA-23 produced by Acinetobacter baumannii was mainly detected in Shanghai and Jiangsu, but it was AmpC enzyme in Zhejiang, Guangdong and Chongqing. Conclusion It is consistent on producing OXA-23 and AmpC by Acinetobacter baumannii in the whole country, but there are some differences among different regions.
Objective To compare the OXA-23 and AmpC enzyme produced by Acinetobacter baumannii in 8 provinces, so as to analyze the resistance mechanism. Methods The reports on the resistance mechanism of Acinetobacter baumannii were comprehensively gathered, and the information of producing OXA-23, AmpC enzyme was made a full analysis by Meta analysis method. Results Pertinent literature in 8 provinces was collected. There was no significant difference in producing OXA-23 and AmpC enzyme in general(χ2=0.1183, P=0.7309); However, the differences among different regions were present. The OXA-23 produced by Acinetobacter baumannii was mainly detected in Shanghai and Jiangsu, but it was AmpC enzyme in Zhejiang, Guangdong and Chongqing. Conclusion It is consistent on producing OXA-23 and AmpC by Acinetobacter baumannii in the whole country, but there are some differences among different regions.
引文
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[4]侯盼飞,王欣,李秀玲,等.耐碳青霉烯类鲍氏不动杆菌耐药机制研究[J].中华医院感染学杂志,2016,26(23):5292-5294.
[5]王辉,孙宏莉,廖康,等.北京和广州地区四家医院不动杆菌碳青霉烯酶基因型研究[J].中华检验医学杂志,2005,28(6):636-641.
[6]刘丽娟.耐亚胺培南鲍曼不动杆菌碳青霉烯酶耐药基因检测及临床研究[J].中华微生物学和免疫学杂志,2015(4):252.
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[9]刘薇,李禄俊,龙云,等.2012年某院鲍曼不动杆菌感染分布及耐药性分析[J].国际检验医学杂志,2014,35(5):576-577.
[10]程巧菊,许苔希.OXA-23型酶介导的鲍曼不动杆菌对碳青霉烯类抗生素耐药分子传播机制[J].浙江临床医学,2015(6):903-905.
[11]袁咏梅,许波银,姜燕南,等.ICU鲍氏不动杆菌医院感染耐药性分析[J].中华医院感染学杂志,2013,23(13):3249-3251.
[12]马冬梅,齐宏伟.2010-2012年临床分离鲍曼不动杆菌的耐药监测[J].检验医学与临床,2013,10(20):2715-2716.
[13]曹春鸾.多重耐药鲍曼不动杆菌β-内酰胺酶基因型研究[J].实用医技杂志,2006,13(2):173-176.
[14]邓德耀,袁文丽,吴迪,等.重症监护病房耐碳青霉烯类鲍曼不动杆菌碳青霉烯酶基因型的检测[J].昆明医科大学学报,2015,36(7):62-66.
[15]史伟峰,姜建平,姚玉华.鲍曼不动杆菌的耐药性及β-内酰胺酶基因的研究[J].临床检验杂志,2005,23(4):275-276.
[16]史利宁,张慧,邵海枫,等.泛耐型鲍曼不动杆菌耐药机制的探讨[J].临床检验杂志,2008,26(5):327-330.
[17]余广超,叶聪秀,陈锐忠,等.鲍曼不动杆菌中OXA碳青霉烯酶的表型筛选与PCR检测[J].中国微生态学杂志,2014,26(12):1389-1392.
[2]Lichtenstein MJ,Mulrow CD,Elwood PC.Guidelines for reading case-control studies[J].J Chron Dis,1987,40(9):893-903.
[3]黄贺梅,韩忠敏.2011-2013年鲍曼不动杆菌耐药性变迁研究[J].现代预防医学,2015,42(11):2060-2061,2077.
[4]侯盼飞,王欣,李秀玲,等.耐碳青霉烯类鲍氏不动杆菌耐药机制研究[J].中华医院感染学杂志,2016,26(23):5292-5294.
[5]王辉,孙宏莉,廖康,等.北京和广州地区四家医院不动杆菌碳青霉烯酶基因型研究[J].中华检验医学杂志,2005,28(6):636-641.
[6]刘丽娟.耐亚胺培南鲍曼不动杆菌碳青霉烯酶耐药基因检测及临床研究[J].中华微生物学和免疫学杂志,2015(4):252.
[7]应春妹,凌健华.碳青霉烯类耐药鲍曼不动杆菌基因的研究[J].上海第二医科大学学报,2004,24(S1):28-30,36.
[8]骆俊,沈继录,徐晓刚,等.耐碳青霉烯类抗生素不动杆菌的β-内酰胺酶研究[J].中国感染与化疗杂志,2007,7(2):79-83.
[9]刘薇,李禄俊,龙云,等.2012年某院鲍曼不动杆菌感染分布及耐药性分析[J].国际检验医学杂志,2014,35(5):576-577.
[10]程巧菊,许苔希.OXA-23型酶介导的鲍曼不动杆菌对碳青霉烯类抗生素耐药分子传播机制[J].浙江临床医学,2015(6):903-905.
[11]袁咏梅,许波银,姜燕南,等.ICU鲍氏不动杆菌医院感染耐药性分析[J].中华医院感染学杂志,2013,23(13):3249-3251.
[12]马冬梅,齐宏伟.2010-2012年临床分离鲍曼不动杆菌的耐药监测[J].检验医学与临床,2013,10(20):2715-2716.
[13]曹春鸾.多重耐药鲍曼不动杆菌β-内酰胺酶基因型研究[J].实用医技杂志,2006,13(2):173-176.
[14]邓德耀,袁文丽,吴迪,等.重症监护病房耐碳青霉烯类鲍曼不动杆菌碳青霉烯酶基因型的检测[J].昆明医科大学学报,2015,36(7):62-66.
[15]史伟峰,姜建平,姚玉华.鲍曼不动杆菌的耐药性及β-内酰胺酶基因的研究[J].临床检验杂志,2005,23(4):275-276.
[16]史利宁,张慧,邵海枫,等.泛耐型鲍曼不动杆菌耐药机制的探讨[J].临床检验杂志,2008,26(5):327-330.
[17]余广超,叶聪秀,陈锐忠,等.鲍曼不动杆菌中OXA碳青霉烯酶的表型筛选与PCR检测[J].中国微生态学杂志,2014,26(12):1389-1392.