双歧杆菌四联活菌片辅助蓝光照射治疗新生儿黄疸的疗效
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摘要
目的:探讨双歧杆菌四联活菌片辅助蓝光照射治疗新生儿黄疸的疗效。方法:118例新生儿黄疸患儿被随机分为观察组(n=59)及对照组(n=59),对照组单纯接受蓝光照射治疗,观察组接受双歧杆菌四联活菌片辅助蓝光照射治疗,比较两组患儿的胆红素相关指标、神经损伤指标、肝功能指标等水平值。结果:观察组患儿治疗后3日的总胆红素(TSB)、直接胆红素(DB)、经皮黄疸指数(TCB)水平均低于对照组患儿(P<0.05);观察组患儿治疗后3日的血清神经元特异性烯醇化酶(NSE)、β淀粉样蛋白(Aβ)、星形胶质源性蛋白(S100β)水平低于对照组患者(P<0.05);观察组患儿治疗后3日的谷丙转氨酶(ALT)、谷草转氨酶(AST)水平低于对照组患儿(P<0.05)。结论:双歧杆菌四联活菌片辅助蓝光照射治疗新生儿黄疸效果较好,在降低胆红素水平、保护神经功能及肝功能等方面均有优势。
Objective:To investigate the effect of bifidobacterium tetragenous viable bacteria tablets-assisted blu-ray irradiation on treatment of neonatal jaundice.Methods:A total of 118 cases with neonatal jaundice were randomly divided into observation group(n=59)and control group(n=59).Patients in control group received blu-ray irradiation treatment alone,while patients in observation group received bifidobacterium tetragenous viable bacteria tablets-assisted blu-ray irradiation treatment.Levels of bilirubin-related indicators,nerve damage indexes and liver function indexes of two groups were compared.Results:Three days after treatment,total serum bilirubin(TSB),direct bilirubin(DB)and transcutaneous bilirubin(TCB)levels of observation group were significantly lower than those of control group(P<0.05);serum neuron specific enolase(NSE),amyloidβ-protein(Aβ)and astrocyte-derived protein(S100β)levels of observation group were significantly lower than those of control group(P<0.05);alanine aminotransferase(ALT)and aspartate aminotransferase(AST)levels of observation group were significantly lower than those of control group(P<0.05).Conclusion:Bifidobacterium tetragenous viable bacteria tablets-assisted blu-ray irradiation has better effect in treatment of neonatal jaundice and has advantages in reducing bilirubin level,protecting nerve function and liver function and other aspects.
Objective:To investigate the effect of bifidobacterium tetragenous viable bacteria tablets-assisted blu-ray irradiation on treatment of neonatal jaundice.Methods:A total of 118 cases with neonatal jaundice were randomly divided into observation group(n=59)and control group(n=59).Patients in control group received blu-ray irradiation treatment alone,while patients in observation group received bifidobacterium tetragenous viable bacteria tablets-assisted blu-ray irradiation treatment.Levels of bilirubin-related indicators,nerve damage indexes and liver function indexes of two groups were compared.Results:Three days after treatment,total serum bilirubin(TSB),direct bilirubin(DB)and transcutaneous bilirubin(TCB)levels of observation group were significantly lower than those of control group(P<0.05);serum neuron specific enolase(NSE),amyloidβ-protein(Aβ)and astrocyte-derived protein(S100β)levels of observation group were significantly lower than those of control group(P<0.05);alanine aminotransferase(ALT)and aspartate aminotransferase(AST)levels of observation group were significantly lower than those of control group(P<0.05).Conclusion:Bifidobacterium tetragenous viable bacteria tablets-assisted blu-ray irradiation has better effect in treatment of neonatal jaundice and has advantages in reducing bilirubin level,protecting nerve function and liver function and other aspects.
引文
1刘想,丁宇.蓝光治疗照射对新生儿ABO血溶性黄疸的疗效分析[J].科技通报,2015,31(5):74-76.
2 刘玲,张路,蒋榆辉,等.苯巴比妥钠联合蓝光照射治疗难治性或迁延性新生儿黄疸的研究[J].昆明医科大学学报,2014,35(11):112-114.
3 刘烨秋.蓝-绿光联合照射治疗新生儿病理性黄疸的疗效分析[J].河北医药,2013,35(10):1512-1514.
4 卢文华.联合茵栀黄颗粒、双歧杆菌四联活菌片、思密达治疗新生儿病理性黄疸临床疗效观察[J].当代医学,2014,20(10):120-122.
5 邓林龙.双歧杆菌四联活菌片合茵栀黄颗粒治疗新生儿黄疸86例临床观察[J].中国名族民间医药,2014,11(3):66-68.
6 王向红,张雅芝.茵栀黄颗粒佐治新生儿高胆红素血症43例疗效观察[J].山东医药,2010,50(41):108-110.
7 李慧.双歧杆菌四联活菌片联合黄疸茵陈口服液治疗新生儿黄疸[J].中国现代药物应用,2011,18(7):7-9.
8 李举,郝晓广.蓝光联合茵栀黄颗粒治疗新生儿病理性黄疸临床疗效分析[J].中国生化药物杂志,2014,1(34):121-123.
9 Mreihil K,Madsen P,Nakstad B,et al.Early formation of bilirubin isomers during phototherapy for neonatal jaundice:effects of single vs.double fluorescent lamps vs.photodiodes[J].Pediatr Res,2015,78(1):56-62.
10 Stanford JA,Shuler JM,Fowler SC,et al.Hyperactivity in the Gunn rat model of neonatal jaundice:age-related attenuation and emergence of gait deficits[J].Pediatr Res,2015,77(3):434-439.
2 刘玲,张路,蒋榆辉,等.苯巴比妥钠联合蓝光照射治疗难治性或迁延性新生儿黄疸的研究[J].昆明医科大学学报,2014,35(11):112-114.
3 刘烨秋.蓝-绿光联合照射治疗新生儿病理性黄疸的疗效分析[J].河北医药,2013,35(10):1512-1514.
4 卢文华.联合茵栀黄颗粒、双歧杆菌四联活菌片、思密达治疗新生儿病理性黄疸临床疗效观察[J].当代医学,2014,20(10):120-122.
5 邓林龙.双歧杆菌四联活菌片合茵栀黄颗粒治疗新生儿黄疸86例临床观察[J].中国名族民间医药,2014,11(3):66-68.
6 王向红,张雅芝.茵栀黄颗粒佐治新生儿高胆红素血症43例疗效观察[J].山东医药,2010,50(41):108-110.
7 李慧.双歧杆菌四联活菌片联合黄疸茵陈口服液治疗新生儿黄疸[J].中国现代药物应用,2011,18(7):7-9.
8 李举,郝晓广.蓝光联合茵栀黄颗粒治疗新生儿病理性黄疸临床疗效分析[J].中国生化药物杂志,2014,1(34):121-123.
9 Mreihil K,Madsen P,Nakstad B,et al.Early formation of bilirubin isomers during phototherapy for neonatal jaundice:effects of single vs.double fluorescent lamps vs.photodiodes[J].Pediatr Res,2015,78(1):56-62.
10 Stanford JA,Shuler JM,Fowler SC,et al.Hyperactivity in the Gunn rat model of neonatal jaundice:age-related attenuation and emergence of gait deficits[J].Pediatr Res,2015,77(3):434-439.