近红外光谱法对云南白药胶囊真伪的定性鉴别分析
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摘要
目的利用近红外光谱技术快速建立品牌药品云南白药胶囊的近红外定性鉴别模型,以打击假冒伪劣产品,为净化药品市场提供有力的技术保障。方法采用近红外光谱系统,利用OPUS 5.0光谱分析软件进行处理,采用矢量归一化法,在9963～4200 cm~(-1)谱段范围内建立快速鉴别定性模型。结果建立的近红外光谱定性模型可以快速、准确地判断出云南白药胶囊的真伪。结论此方法建立的品牌模型,能简便、快速、准确的对该品牌药品进行真伪鉴别,并可灵活地应用于日常监督检查过程中的药品快速筛查。
Objective To establish a near-infrared qualitative identification model of brand-based Yunnan Baiyao Capsules rapidly using near-infrared spectroscopy(NIS) technology to crack down counterfeit and sham products and provide a strong technical guarantee for the purification of drug market. Methods By NIS, the OPUS 5.0 spectral analysis software was used for processing. The qualitative identification model in the spectral range of 9963-4200 cm-1 was rapidly established using vector normalization. Results The established NIS qualitative model can determine the authenticity of Yunnan Baiyao Capsules quickly and accurately. Conclusion The brand model established by this method can verify the authenticity of the drugs easily, quickly and accurately, and can be flexibly applied to the rapid screening of drugs in the daily supervision and inspection process.
Objective To establish a near-infrared qualitative identification model of brand-based Yunnan Baiyao Capsules rapidly using near-infrared spectroscopy(NIS) technology to crack down counterfeit and sham products and provide a strong technical guarantee for the purification of drug market. Methods By NIS, the OPUS 5.0 spectral analysis software was used for processing. The qualitative identification model in the spectral range of 9963-4200 cm-1 was rapidly established using vector normalization. Results The established NIS qualitative model can determine the authenticity of Yunnan Baiyao Capsules quickly and accurately. Conclusion The brand model established by this method can verify the authenticity of the drugs easily, quickly and accurately, and can be flexibly applied to the rapid screening of drugs in the daily supervision and inspection process.
引文
[1]胡昌勤,冯艳春.近红外光谱法快速分析药品[M].北京:化学工业出版社,2010:64-105.
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[12]李奇,田静,闻琍毓.运用近红外光谱法对心可宁胶囊一致性检验的研究[J].天津药学,2014,26(2):22-23.
[13]戴震,胡小崧.甲钴胺片近红外一致性检验模型的建立[J].中国药物评价,2017,34(2):95-96.
[14]王海波,朱健萍,邓鸣,等.近红外光谱法快速分析头孢克肟胶囊的含量[J].中国抗生素杂志,2014,39(1):45-48.
[15]张燕芬.伏格列波糖胶囊近红外一致性检验模型的建立[J].中国药物评价.2017,34(3):161-162.
[16]于畅游,刘云飞,张肖宁.注射用阿莫西林钠舒巴坦钠近红外通用型模型的建立[J].中国药物评价,2017,34(1):22-24.
[17]王宇,黄巧巧,洪利娅.西洛他唑片近红外光谱定性分析模型的建立[J].海峡药学,2015,(8):50-52.
[18]曾焕俊,韩莹.复方盐酸伪麻黄碱缓释胶囊近红外定性模型的建立[J].今日药学,2010,20(9):34-36.
[2]付小环,胡军华,李家春,等.应用近红外光谱技术对茯苓药材进行定性定量检测研究[J].中国中药杂志,2015,40(2):280-286.
[3]马启龙,邓树勇,李文利.5种复方感冒药的近红外定性模型的建立[J].药物分析杂志,2010,30(8):1556-1559.
[4]韩莹,毕福钧,侯惠婵,等.近红外光谱法鉴别何首乌真伪的应用研究[J].中国中药杂志,2014,39(22):4394-4398.
[5]张永耀,韩莹,侯惠婵,等.建立品牌药品的近红外打假模型[J].中药材,2010,33(8):1243-1245.
[6]尼珍,胡昌勤,冯芳.近红外光谱分析中光谱预处理方法的作用及其发展[J].药物分析杂志,2008,28(5):824-829.
[7]余驰,姜红,刘爱萍.近红外漫反射光谱法建立厚朴药材的定性模型[J].药物分析杂志,2009,29(4):656-658.
[8]周瑞雪,张英,郭景文.中药制剂麝香保心丸近红外光谱定性模型的建立[J].中国药事,2016,30(6):593-597.
[9]史大军,潘龙珍.中成药胶囊剂假药近红外识别模型的研究[J].中国药业,2014,23(3):28-29.
[10]曾焕俊,韩莹.中药制剂通心络胶囊近红外定性模型的建立[J].中国药事,2011,25(4):373-374.
[11]黄伟民,黄伟静.头孢呋辛酯片近红外光谱法定性模型的建立[J].亚太传统医学,2011,7(6):9-11.
[12]李奇,田静,闻琍毓.运用近红外光谱法对心可宁胶囊一致性检验的研究[J].天津药学,2014,26(2):22-23.
[13]戴震,胡小崧.甲钴胺片近红外一致性检验模型的建立[J].中国药物评价,2017,34(2):95-96.
[14]王海波,朱健萍,邓鸣,等.近红外光谱法快速分析头孢克肟胶囊的含量[J].中国抗生素杂志,2014,39(1):45-48.
[15]张燕芬.伏格列波糖胶囊近红外一致性检验模型的建立[J].中国药物评价.2017,34(3):161-162.
[16]于畅游,刘云飞,张肖宁.注射用阿莫西林钠舒巴坦钠近红外通用型模型的建立[J].中国药物评价,2017,34(1):22-24.
[17]王宇,黄巧巧,洪利娅.西洛他唑片近红外光谱定性分析模型的建立[J].海峡药学,2015,(8):50-52.
[18]曾焕俊,韩莹.复方盐酸伪麻黄碱缓释胶囊近红外定性模型的建立[J].今日药学,2010,20(9):34-36.