胶束在中药制剂中的应用研究
摘要
两亲聚合物在选择性溶剂(对一片段为良溶剂同时对另一片段为劣溶剂)中,在分子间的氢键、静电相互作用和范德华力等推动下自发构筑形成聚合物胶束,溶解性差的片段形成胶束的核,溶解性好的片段形成溶剂化壳层。开始大量形成胶束时的聚合物浓度为临界胶束浓度(CMC)。聚合物胶束的形状以球形最为常见,此外还有棒状、囊状、片状、管状、星状等聚合物胶束的粒径通常在1~200 nm之间时,属于物质由宏观世界向微观世界的过渡区域。这种特殊结构可导致四种效应:小尺寸效应、表面与界面效应、量子尺寸效应和宏观量子隧道效应,并表现出传统固体物质所不具备的许多特殊性质。
引文
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[32]Wang X F,Zhou Q M,Du J.Baicalin suppressesmigration,invasion and metastasis of breast cancer viap38MAPKsignaling pathway[J].Anti-Cancer Agents in Medicinal Chemistry,2013,13(6):923-931.
[33]马文转,王金铃,屠鹏飞.黄芩苷纳米胶束的制备、表征及其对MCF-7细胞抑制作用的研究[J].中草药,2015,46(4):507-512.
[34]张海群.黄芩苷口服混合胶束制剂的研究[D].济南:山东大学,2015.
[35]CRAGG G M.Paclitaxel(Taxol):A success story with valuable lessons for natural product drug discovery and development[J].Medicinal Research Reviews,1998,18(5):315-331.
[36]KIM S C,KIM D W,SHIM Y H,et al.In vivo evaluation of polymeric micellar paclitaxel formulation:toxicity and efficacy[J].Journal of Controlled Release,2001,72(1):191-202.(下转第页)
[37]REDDY L H,BAZILE D.Drug delivery design for intravenous route with integrated physicochemistry,pharmacokinetics and pharmacodynamics:Illustration with the case of taxane therapeutics[J].Advanced Drug Delivery Reviews,2013,71:34-57.
[38]MADAAN A,SINGH P,AWASTHI A,et al.Efficiency and mechanism of intracellular paclitaxel delivery by novel nanopolymer-based tumor-targeted delivery system,Nanoxel TM[J].Clinical and Translational Oncology,2013,15(1):26-32.
[39]李远达,朱亮.聚合物胶束在肿瘤治疗中的研究进展[J].中国医药工业杂志,2010,41(8):615-621.
[40]典灵辉,于恩江,程纪伦,等.大黄素soluplus聚合物胶束的制备及质量评价[J].中国实验方剂学杂志,2014,20(16):15-18.
[2]徐晖,丁平田,王绍宁,等.聚合物胶束药物传递系统的研究进展[J].中国医药上业杂志,2004,35(10):626-629.
[3]张跃庭,董岸杰,邓联东,等.水溶性紫杉醇两亲性共聚物胶束研究[J].化学上程,2005,33(2):40-43.
[4]Lee A L.Wang Y.Cheng H Y,et al.The co-delivery of paclitaxel and Herceptin using cationic micellar nanoparticles[J].B-mete rinl.s,2009,30(5):919-927.
[5]周芬,杨子刚,翟超,等.嵌段共聚物PLL-PEG-PLL/DNA复合物胶束[J].北学与生物上程,2004,21(5):26-28.
[6]徐建平,陈伟东,计剑,等.新型仿生聚合物胶束用于纳米药物载体的研究[J].高等学校化学学报,2007,28(2):394-396.
[7]Strickley R G,Solubilizing excipients in oral and injectable formulations[J].Pharm Res,2004,21:201-230.
[8]Sant V P,Smith D,Leroux J C.Novel p H-sensitive supramolecular assemblies for oral delivery of poorly water soluble drugs preparation and characterization[J].J Control Release,2004,97:301-312.
[9]Blanchette J,Peppas NA.Oral chemotherapeutic delivery design and cellular response[J].Annals Biomed Eng,2005,33:142-149.
[10]Dufresne M H,Garrec D L,Sant V,et al.Preparation and characterization of water-soluble p H-sensitive nanocarriers for drug delivery[J].Int J Pharm,2004,277:81-90.
[11]Yamamoto Y,Xnagasaki Y,Kato Y,et al.Long-circulating poly(ethylene glycol)-poly(L,D-lactide)block copolymer micelles with modulated surface charge[J].Control Release,2001,77:27-38.
[12]Torchilin V P.Structure and design of polymeric surfactantbased drug delivery systems[J].J Control Release,2001,73:137-172.
[13]Shalaby W S,Karen J L B.Absorbable and Biodegradable Polymers[M].Boca Raton:CRC press,2005:40-54.
[14]Gaucher G,Dufresne M H,Sant V P,et al.Block copolymer micelles:preparation,characterization and application in drug delivery[J].J Control Release,2005,109:169-188.
[15]Benahmed A,Ranger M,Leroux J C.Novel polymeric micelles based on the amphiphilic diblock copolymer poly(N-vinyl-2-pyrrolidone)-blockpoly(D,L-lactide)[J].Pharm Res,2001,18:323-328.
[16]Luo LB,Ranger M,Lessard D G,et al.Novel amphiphilic diblock copolymer of low molecular weight poly(N-vinylpyr-rolidone)-block-poly(d,l-lactide):synthesis,characterization,and micellization[J].Macromolecules,2004,37:4008-4013.
[17]肖长坤.姜黄属植物的化学成分研究进展[J].中国实验方剂学杂志,2012,18(21):339.
[18]余关荣,蒋福升,丁志山.姜黄素的研究进展[J].中草药,2009,40(5):828.
[19]Maiti K,Mukherjee K,Gantait A,et al.Curc;uminphospholipid complex:preparation,therapeutic;evaluation and pharmac;okinetic;study in rats[J].Int J Pharm,2007,330(1/2):155.
[20]韩刚,翟丽,赵琳琳,等姜黄素固体分散体在大鼠体内的药动学研究[J].中国药学杂志,2009,44(9):698.
[21]韩刚,许建华,李魏娜,等.姜黄素a环糊精包合物的制备工艺研究[J].中药材,2004,27(12):946.
[22]MA Z,Shayeganpour A,Brocks D R et al.Highperformance liquid chromatography analysis of c;urc;umin in rat plasma:application to pharmac;okinetic、of Lx lymeric micellar formulation of curcumin[J].Biomed Chromato,2007,21(5):546.
[23]张峻颖.姜黄素Pluronic F127载药胶束的制备及其胶束化行为的NMR分析[J].中国实验方剂学杂志,2013,24(19):1-4.
[24]Ma Z,Shayeganpour A,Brocks D R,et al.High-performance liquid chromatography analysis of curcumin in rat plasma:application to pharmacokinetics of polymeric micellar formulation of curcumin[J].Biomed Chromatogr,2007,21(5):546-552.
[25]Yu H L,Huang Q G.Enhanced in vitro anti-cancer activity of curcumin encapsulated in hydrophobically modified starch[J].Food Chemistry,2010,119(2):669-674.
[26]Sahu A,Bora U,Kasoju N,et al.Synthesis of novel biodegradable and self-assembling methoxy polyethylene glycol)-palmitate nanocarrier for curcumin delivery to cancer cells[J].Acta Biomater,2008,4(6):1752-1761.
[27]Li J,Wang Y,Yang C,et al.Polyethylene glycosylated curcumin conjugate inhibits pancreatic cancer cell growth through inactivation of Jab 1[J].Mol Pharmacol,2009,76(1):81-90.
[28]辛文好,宋俊科,何国荣,等.作用及机制研究进展[J].黄答素和黄答昔的药理中国新药杂志,2013,22(6):647-659.
[29]Ikemoto S,Sugimura K K,Nakatani T.Antitumor effects of lipoxygenase inhibitors on murine bladder cancer cell line(MBT-2)[J].Anticancer Research,2004,24(2B):733-738.
[30]Wang N,Tang L J,Zhu G Q.Apoptosis induced by baicalin involving up-regulation of P53 and bax in MCF-7 cells[J].J Asian Prod Res,2008,10(12):1129-1235.
[31]Chen J,Li Z,Chen A.Inhibitory effect of baicalin and baicalein on ovarian cancer cells[J].Int J Mol Sci,2013,14(3):6012-6025.
[32]Wang X F,Zhou Q M,Du J.Baicalin suppressesmigration,invasion and metastasis of breast cancer viap38MAPKsignaling pathway[J].Anti-Cancer Agents in Medicinal Chemistry,2013,13(6):923-931.
[33]马文转,王金铃,屠鹏飞.黄芩苷纳米胶束的制备、表征及其对MCF-7细胞抑制作用的研究[J].中草药,2015,46(4):507-512.
[34]张海群.黄芩苷口服混合胶束制剂的研究[D].济南:山东大学,2015.
[35]CRAGG G M.Paclitaxel(Taxol):A success story with valuable lessons for natural product drug discovery and development[J].Medicinal Research Reviews,1998,18(5):315-331.
[36]KIM S C,KIM D W,SHIM Y H,et al.In vivo evaluation of polymeric micellar paclitaxel formulation:toxicity and efficacy[J].Journal of Controlled Release,2001,72(1):191-202.(下转第页)
[37]REDDY L H,BAZILE D.Drug delivery design for intravenous route with integrated physicochemistry,pharmacokinetics and pharmacodynamics:Illustration with the case of taxane therapeutics[J].Advanced Drug Delivery Reviews,2013,71:34-57.
[38]MADAAN A,SINGH P,AWASTHI A,et al.Efficiency and mechanism of intracellular paclitaxel delivery by novel nanopolymer-based tumor-targeted delivery system,Nanoxel TM[J].Clinical and Translational Oncology,2013,15(1):26-32.
[39]李远达,朱亮.聚合物胶束在肿瘤治疗中的研究进展[J].中国医药工业杂志,2010,41(8):615-621.
[40]典灵辉,于恩江,程纪伦,等.大黄素soluplus聚合物胶束的制备及质量评价[J].中国实验方剂学杂志,2014,20(16):15-18.