摘要
以医用材料泊洛沙姆407为原料,采用羰基二咪唑活化泊洛沙姆分子的端羟基,在氮气保护的温和条件下,乙二胺与活化泊洛沙姆发生氨基化反应,制备出含有氨基末端的泊洛沙姆新材料,为泊洛沙姆偶联疏水性药物或功能性基团的开发奠定基础。
The medical material poloxamer 407 was used as the raw material,and the hydroxyl terminal of itsmolecules was activated by N,N'-Carbonyldiimidazole(CDI). With the occurrence of the amino-reaction of bothethylenediamine and activated poloxamer, a new poloxamer material containing an amino terminal was prepared,which laid a foundation for the future coupling of hydrophobic drugs or functional groups to poloxamers.
引文
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