温敏型医药材料泊洛沙姆407的改性研究
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摘要
以医用材料泊洛沙姆407为原料,采用羰基二咪唑活化泊洛沙姆分子的端羟基,在氮气保护的温和条件下,乙二胺与活化泊洛沙姆发生氨基化反应,制备出含有氨基末端的泊洛沙姆新材料,为泊洛沙姆偶联疏水性药物或功能性基团的开发奠定基础。
The medical material poloxamer 407 was used as the raw material,and the hydroxyl terminal of itsmolecules was activated by N,N'-Carbonyldiimidazole(CDI). With the occurrence of the amino-reaction of bothethylenediamine and activated poloxamer, a new poloxamer material containing an amino terminal was prepared,which laid a foundation for the future coupling of hydrophobic drugs or functional groups to poloxamers.
The medical material poloxamer 407 was used as the raw material,and the hydroxyl terminal of itsmolecules was activated by N,N'-Carbonyldiimidazole(CDI). With the occurrence of the amino-reaction of bothethylenediamine and activated poloxamer, a new poloxamer material containing an amino terminal was prepared,which laid a foundation for the future coupling of hydrophobic drugs or functional groups to poloxamers.
引文
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[2]Hong-Ru Lin,K.C.Sung.In Situ Gelling of Alginate/Pluronic Solutions for Ophthalmic Delivery of Pilocarpine[J].Biomacromolecules,2004,5(6):2358-2365.
[3]谢宇,吕中元,孙昭艳,安立佳,李秀宏,吴忠华.17R4/F127混合水溶液的凝胶结构[J].高等学校化学学报,2013,34(6):1521-1526.
[4]吴玲,林荣强,邹少华,孙海燕.乳酸环丙沙星温度敏感眼用凝胶的体外释放研究[J].中国药业,2011,20(24):24-25.
[5]张利,毕宏生,解孝锋,郭俊国.眼用原位凝胶的药学研究进展[J].国际眼科杂志,2011,11(10):1740-1742.
[6]Arbelaez-Camargo D,Sun?é-Negre JM,Roig-Carreras M,García-Montoya E,Pérez-Lozano P,Min?arro-Carmona M,Ticó-Grau JR.Preformulation and characterization of a lidocaine hydrochloride and dexamethasone sodium phosphate thermo-reversible and bioadhesive long-acting gel for intraperitoneal administration[J].International Journal of Pharmaceutics,2016(6):142-152.
[7]张桂贤,胡人杰,邓联东,王伟伟,李文畅.紫杉醇-PECT原位凝胶抗肿瘤作用的初步评价[J].时珍国医国药,2012,23(9):2215-2217.
[8]杨君,杨跃辉,郜琪臻,丁平田.盐酸米诺环素缓释原位凝胶的处方工艺研究[J].山西医药杂志,2012,41(7):762-763.