乙酰半胱氨酸泡腾片对肥胖哮喘患者气道炎症及肺功能的影响
摘要
目的探讨乙酰半胱氨酸泡腾片对肥胖哮喘患者气道炎症及肺功能的影响。方法 60例肥胖哮喘患者,随机分为对照组和治疗组,各30例。对照组采用布地奈德治疗,治疗组在对照组治疗基础上加用乙酰半胱氨酸泡腾片治疗,比较两组治疗前后肺功能指标[第1秒用力呼气容积占预计值百分比(FEV1%)、最大呼气峰流速(PEF)]及炎症因子[白细胞介素(IL)-4、IL-13]水平。结果治疗前,两组IL-4、IL-13水平比较,差异无统计学意义(P>0.05);治疗后,两组IL-4、IL-13水平均低于治疗前,且治疗组IL-4水平(4.18±0.98)pg/ml、IL-13水平(26.83±6.99)pg/ml均低于对照组的(6.53±1.07)、(39.12±7.19)pg/ml,差异有统计学意义(P<0.05)。治疗前,两组FEV1%、PEF比较,差异无统计学意义(P>0.05);治疗后两组FEV1%、PEFf均高于治疗前,且治疗组FEV1%(73±8)%、PEF(348±42)L/min均明显高于对照组的(66±7)%、(275±48)L/min,差异有统计学意义(P<0.05)。结论乙酰半胱氨酸泡腾片联合布地奈德治疗肥胖哮喘,较单用布地奈德能明显改善患者肺功能,降低患者炎症因子水平,缓解气道炎症。
引文
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[6]余江清.乙酰半胱氨酸泡腾片合用噻托溴铵吸入剂对50例COPD合并肺气肿的临床疗效研究.上海医药,2016,37(7):29-31.
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[3]Calixto MC,Lintomen L,Schenka A,et al.Obesity enhances eosinophilic inflammation in a murine model of allergic asthma.Br JPharmacol,2010,159(3):617-625.
[4]Schütze N,Lehmann I,Bonisch U,et al.Exposure to mycotoxins increases the allergic immune response in a murine asthma model.Am J Respir Crit Care Med,2010,181(11):1188-1199.
[5]周洋,张家洪,黄河,等.乙酰半胱氨酸泡腾片对慢性阻塞性肺疾病患者炎性反应及氧化/抗氧化失衡的影响研究.检验医学与临床,2014,11(5):668-669.
[6]余江清.乙酰半胱氨酸泡腾片合用噻托溴铵吸入剂对50例COPD合并肺气肿的临床疗效研究.上海医药,2016,37(7):29-31.
[7]Gibeon D,Batuwita K,Osmond M,et al.Obesity-associated severe asthma represents a distinct clinical phenotype:analysis of the British Thoracic society Difficult Asthma Registry Patient cohort according to BMI.Chest,2013,143(2):406-414.