基孔肯雅病毒研究进展
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摘要
基孔肯雅病毒(CHIKV)是一种虫媒病毒,可通过埃及伊蚊和白纹伊蚊传播,感染率高,能够引起长达数月至数年的关节炎症状,严重者会造成残疾甚至致死。近几年来,CHIKV在全球范围内广泛传播,每年可导致数百万人感染。本文从临床症状、病理机制、诊断方法等几方面介绍了CHIKV的最新研究进展,其中CHIKV感染的病理机制是重点描述的部分,了解CHIKV感染的致病机制将有助于找到预防和治疗方法来对抗这种虫媒病毒感染。
Chikungunya virus(CHIKV) is an insect-borne virus transmitted by Aedes aegypti and Aedes albopictus. It has a high infection rate and can cause arthritis symptoms lasting from months to years. In severe cases, it can cause disability and even death. CHIKV has spread worldwide in recent years, infecting millions of people each year. This review introduces CHIKV from the aspects of clinical symptoms, pathological mechanism and diagnostic methods, among which, the pathological mechanism of CHIKV infection is the key part described. Understanding the pathological mechanism of CHIKV infection will be beneficial to finding methods of prevention and treatment to fight against this arbovirus.
Chikungunya virus(CHIKV) is an insect-borne virus transmitted by Aedes aegypti and Aedes albopictus. It has a high infection rate and can cause arthritis symptoms lasting from months to years. In severe cases, it can cause disability and even death. CHIKV has spread worldwide in recent years, infecting millions of people each year. This review introduces CHIKV from the aspects of clinical symptoms, pathological mechanism and diagnostic methods, among which, the pathological mechanism of CHIKV infection is the key part described. Understanding the pathological mechanism of CHIKV infection will be beneficial to finding methods of prevention and treatment to fight against this arbovirus.
引文
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[17] Hawman DW,Stoermer KA,Montgomery SA,et al. Chronic joint disease caused by persistent Chikungunya virus infection is controlled by the adaptive immune response[J].J Virol,2013,87(24):13878-13888.
[18] Teo TH,Lum FM,Claser C,et al. A pathogenic role for CD4+T cells during Chikungunya virus infection in mice[J].J Immunol,2013,190(1):259-269.
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[21] Messaoudi I,Vomaske J,Totonchy T,et al. Chikungunya virus infection results in higher and persistent viral replication in aged rhesus macaques due to defects in antiviral immunity[J]. PLoS Negl Trop Dis,2013,7(7):e2343.
[22] Grivard P,Le Roux K,Laurent P,et al. Molecular and serological diagnosis of Chikungunya virus infection[J].Pathol Biol(Paris),2007,55(10):490-494.
[23] Gerardin P,Barau G,Michault A,et al. Multidisciplinary prospective study of mother-to-child chikungunya virus infections on the island of La Reunion[J]. PLoS Med,2008,5(3):e60.
[24] Blagrove MSC,Caminade C,Waldmann E,et al. Co-occurrence of viruses and mosquitoes at the vectors'optimal climate range:An underestimated risk to temperate regions?[J]. PLoS Negl Trop Dis,2017,11(6):e0005604.
[25] Suhrbier A,Jaffar-Bandjee MC,Gasque P. Arthritogenic alphaviruses--an overview[J]. Nat Rev Rheumatol,2012,8(7):420-429.
[26] Krutikov M,Manson J. Chikungunya Virus Infection:An Update on Joint Manifestations and Management[J]. Rambam Maimonides Med J,2016,7(4). doi:10.5041/RMMJ.10260.
[27] Marti-Carvajal A,Ramon-Pardo P,Javelle E,et al. Interventions for treating patients with chikungunya virus infection-related rheumatic and musculoskeletal disorders:A systematic review[J]. PLoS One,2017,12(6):e0179028.
[28] Burt FJ,Chen W,Miner JJ,et al. Chikungunya virus:an update on the biology and pathogenesis of this emerging pathogen[J]. Lancet Infect Dis,2017,17(4):e107-e117.
[29] Abdelnabi R,Neyts J,Delang L. Chikungunya virus infections:time to act,time to treat[J]. Curr Opin Virol,2017,24:25-30.
[2] Wahid B,Ali A,Rafique S,et al. Global expansion of chikungunya virus:mapping the 64-year history[J]. Int J Infect Dis,2017,58:69-76.
[3] Ali Ou Alla S,Combe B. Arthritis after infection with Chikungunya virus[J]. Best Pract Res Clin Rheumatol,2011,25(3):337-346.
[4] Hua C,Combe B. Chikungunya Virus-Associated Disease[J].Curr Rheumatol Rep,2017,19(11):69.
[5] Rahim AA,Thekkekara RJ,Bina T,et al. Disability with Persistent Pain Following an Epidemic of Chikungunya in Rural South India[J]. J Rheumatol,2016,43(2):440-444.
[6] Weaver SC,Lecuit M. Chikungunya virus and the global spread of a mosquito-borne disease[J]. N Engl J Med,2015,372(13):1231-1239.
[7] Rocha VFD,de Oliveira AHP,Bandeira AC,et al. Chikungunya Virus Infection Associated with Encephalitis and Anterior Uveitis[J]. Ocul Immunol Inflamm,2018,26(5):677-679.
[8] Sasmono RT,Perkasa A,Yohan B,et al. Chikungunya Detection during Dengue Outbreak in Sumatra,Indonesia:Clinical Manifestations and Virological Profile[J]. Am J Trop Med Hyg,2017,97(5):1393-1398.
[9] Bandeira AC,Campos GS,Sardi SI,et al. Neonatal encephalitis due to Chikungunya vertical transmission:First report in Brazil[J]. IDCases,2016,5:57-59.
[10] Gasque P,Couderc T,Lecuit M,et al. Chikungunya virus pathogenesis and immunity[J]. Vector Borne Zoonotic Dis,2015,15(4):241-249.
[11] Kam YW,Ong EK,Renia L,et al. Immuno-biology of Chikungunya and implications for disease intervention[J]. Microbes Infect,2009,11(14/15):1186-1196.
[12] Couderc T,Chretien F,Schilte C,et al. A mouse model for Chikungunya:young age and inefficient type-I interferon signaling are risk factors for severe disease[J]. PLoS Pathog,2008,4(2):e29.
[13] Teng TS,Foo SS,Simamarta D,et al. Viperin restricts chikungunya virus replication and pathology[J]. J Clin Invest,2012,122(12):4447-4460.
[14] Haese NN, Broeckel RM, Hawman DW, et al. Animal Models of Chikungunya Virus Infection and Disease[J]. J Infect Dis,2016,214(suppl 5):S482-S487.
[15] Fros JJ,Liu WJ,Prow NA,et al. Chikungunya virus nonstructural protein 2 inhibits typeⅠ/Ⅱinterferon-stimulated JAK-STAT signaling[J]. J Virol,2010,84(20):10877-10887.
[16] Zhang N,Zhao H,Zhang L. Fatty acid synthase promotes the palmitoylation of Chikungunya virus nsP1[J]. J Virol,2019,93(3). doi:10.1128/JVI.01747-18.
[17] Hawman DW,Stoermer KA,Montgomery SA,et al. Chronic joint disease caused by persistent Chikungunya virus infection is controlled by the adaptive immune response[J].J Virol,2013,87(24):13878-13888.
[18] Teo TH,Lum FM,Claser C,et al. A pathogenic role for CD4+T cells during Chikungunya virus infection in mice[J].J Immunol,2013,190(1):259-269.
[19] Poo YS,Rudd PA,Gardner J,et al. Multiple immune factors are involved in controlling acute and chronic chikungunya virus infection[J]. PLoS Negl Trop Dis,2014,8(12):e3354.
[20] Broeckel R,Haese N,Messaoudi I,et al. Nonhuman Primate Models of Chikungunya Virus Infection and Disease(CHIKV NHP Model)[J]. Pathogens,2015,4(3):662-681.
[21] Messaoudi I,Vomaske J,Totonchy T,et al. Chikungunya virus infection results in higher and persistent viral replication in aged rhesus macaques due to defects in antiviral immunity[J]. PLoS Negl Trop Dis,2013,7(7):e2343.
[22] Grivard P,Le Roux K,Laurent P,et al. Molecular and serological diagnosis of Chikungunya virus infection[J].Pathol Biol(Paris),2007,55(10):490-494.
[23] Gerardin P,Barau G,Michault A,et al. Multidisciplinary prospective study of mother-to-child chikungunya virus infections on the island of La Reunion[J]. PLoS Med,2008,5(3):e60.
[24] Blagrove MSC,Caminade C,Waldmann E,et al. Co-occurrence of viruses and mosquitoes at the vectors'optimal climate range:An underestimated risk to temperate regions?[J]. PLoS Negl Trop Dis,2017,11(6):e0005604.
[25] Suhrbier A,Jaffar-Bandjee MC,Gasque P. Arthritogenic alphaviruses--an overview[J]. Nat Rev Rheumatol,2012,8(7):420-429.
[26] Krutikov M,Manson J. Chikungunya Virus Infection:An Update on Joint Manifestations and Management[J]. Rambam Maimonides Med J,2016,7(4). doi:10.5041/RMMJ.10260.
[27] Marti-Carvajal A,Ramon-Pardo P,Javelle E,et al. Interventions for treating patients with chikungunya virus infection-related rheumatic and musculoskeletal disorders:A systematic review[J]. PLoS One,2017,12(6):e0179028.
[28] Burt FJ,Chen W,Miner JJ,et al. Chikungunya virus:an update on the biology and pathogenesis of this emerging pathogen[J]. Lancet Infect Dis,2017,17(4):e107-e117.
[29] Abdelnabi R,Neyts J,Delang L. Chikungunya virus infections:time to act,time to treat[J]. Curr Opin Virol,2017,24:25-30.