不同程度动脉导管未闭早产儿餐后肠系膜上动脉血流速增幅及疗效观察
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摘要
目的观察不同程度动脉导管未闭(PDA)早产儿餐后肠系膜上动脉血流速(SMA)增幅、首疗程导管关闭率。方法回顾性分析2017年1月-2019年1月间在本院出生的49例PDA早产儿资料,根据PDA严重程度将患儿分为轻、中、重三组进行对比分析。结果轻度组首疗程导管关闭率为90. 48%、中度组为73. 33%、重度组为23. 08%;三组首疗程导管关闭率均具有统计学差异P<0.05;三组间SMA增幅具有统计学差异(P<0. 05);各项研究指标与PDA程度均具有明确相关性,|r|>0.3(P<0.05)。结论动脉导管未闭患儿病情程度与餐后SMA增幅、首疗程后导管关闭率间均具有明确相关性。
Objective To observe the increase of postprandial blood flow rate( SMA) and the rate of catheter closure in premature infants with different degrees of patent ductusarteriosus( PDA). Methods The data of 49 premature PDA patients born in our hospital from January 2017 to January 2019 were retrospectively analyzed,and the patients were divided into three groups according to the severity of PDA for comparative analysis. Results The rate of catheter closure was 90. 48% in mild group,73.33% in moderate group and 23. 08% in severe group,the closure rate of catheter in the first course of treatment in the three groups showed statistical difference( P<0. 05); the increase of SMA in the three groups was statistically significant( P<0. 05).There was a clear correlation between various research indicators and PDA degree,| r | >0. 3,P<0. 05. Conclusion There was a clear correlation between the severity of the disease and the increase of SMA,feeding tolerance and the rate of catheter closure after the first course of treatment.
Objective To observe the increase of postprandial blood flow rate( SMA) and the rate of catheter closure in premature infants with different degrees of patent ductusarteriosus( PDA). Methods The data of 49 premature PDA patients born in our hospital from January 2017 to January 2019 were retrospectively analyzed,and the patients were divided into three groups according to the severity of PDA for comparative analysis. Results The rate of catheter closure was 90. 48% in mild group,73.33% in moderate group and 23. 08% in severe group,the closure rate of catheter in the first course of treatment in the three groups showed statistical difference( P<0. 05); the increase of SMA in the three groups was statistically significant( P<0. 05).There was a clear correlation between various research indicators and PDA degree,| r | >0. 3,P<0. 05. Conclusion There was a clear correlation between the severity of the disease and the increase of SMA,feeding tolerance and the rate of catheter closure after the first course of treatment.
引文
[1]郑欧弟.口服布洛芬治疗早产儿动脉导管未闭的疗效及安全性分析[J].北方药学,2018,15(3):167.
[2]KIM S Y,SHIN S H,KIM H S,et al.Pulmonary arterial hypertension afteribuprofen treatment for patent ductusarteriosus in very low birth weightinfants[J].The Journal of pediatrics,2016,12(179):49.
[3]陆丹芳,刘云峰,童笑梅,等.早产儿动脉导管未闭的临床特点及其心脏血流动力学研究[J].中华儿科杂志,2015,53(3):187.
[4]PRESCOTT S,KEIM-MALPASS J.Patent ductusarteriosus in the preterminfant:diagnostic and treatment options[J].Adv Neonatal Care,2017,17(1):10.
[5]李向农,江明宏,刘雪梅,等.超声心动图评估口服布洛芬治疗早产儿动脉导管未闭的疗效[J].中国循证心血管医学杂志,2016,8(3):361.
[6]邓如海,哈依霞.布洛芬治疗新生儿动脉导管未闭的疗效观察[J].新疆医学,2018,48(1):74.
[7]YANG B,GAO X,REN Y,et al.Oral paracetamol vs.oral ibuprofen in thetreatment of symptomatic patent ductusarteriosus in premature infants:Arandomized controlled trial[J].Exp Ther Med,2016,12(4):2531.
[2]KIM S Y,SHIN S H,KIM H S,et al.Pulmonary arterial hypertension afteribuprofen treatment for patent ductusarteriosus in very low birth weightinfants[J].The Journal of pediatrics,2016,12(179):49.
[3]陆丹芳,刘云峰,童笑梅,等.早产儿动脉导管未闭的临床特点及其心脏血流动力学研究[J].中华儿科杂志,2015,53(3):187.
[4]PRESCOTT S,KEIM-MALPASS J.Patent ductusarteriosus in the preterminfant:diagnostic and treatment options[J].Adv Neonatal Care,2017,17(1):10.
[5]李向农,江明宏,刘雪梅,等.超声心动图评估口服布洛芬治疗早产儿动脉导管未闭的疗效[J].中国循证心血管医学杂志,2016,8(3):361.
[6]邓如海,哈依霞.布洛芬治疗新生儿动脉导管未闭的疗效观察[J].新疆医学,2018,48(1):74.
[7]YANG B,GAO X,REN Y,et al.Oral paracetamol vs.oral ibuprofen in thetreatment of symptomatic patent ductusarteriosus in premature infants:Arandomized controlled trial[J].Exp Ther Med,2016,12(4):2531.