钩吻现代功效研究进展
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摘要
目的钩吻在我国民间治疗范围广泛,可用于治疗肿瘤、疼痛、类风湿等多种疾病。然而误服中毒甚至死亡的情况也时有发生,需要了解其现代功效,进一步应用于临床。方法随着近代实验研究和药理研究的发展,特别是在治疗肿瘤及疼痛方面的研究。通过大量阅读钩吻相关文献,对钩吻在抗肿瘤、镇痛剂其他作用进行综述。结果钩吻具有明显的抗肿瘤及镇痛作用,同时具有抗焦虑、修复放射损伤及放射增敏、造血保护、抗炎、抗曲霉菌等作用。结论钩吻具有良好的药用前景,为开发适合临床应用药物提供参考。
Objective:The Gelsemium widespread in our country folk therapeutic range,such as tumors,pain,rheumatoid arthritis and so on.However,when accidental poisoning occasionally occurred,this is all the more urgent needs to know its modern function and its clinical application fields.Methods:With the development of modern research and pharmacological research experiments,its effect has been further defined,particularly in the treatment of tumors and pain.The purpose of this paper reviewing many literature is to discuss the modern application of Gelsemium elegans,especially in anti tumor and pains research.Results:The Gelsemium has obvious anti-tumor,analgesic effect,anti-anxiety,repair radiation damage,radiation sensitization,hematopoietic protection,anti-inflammatory,anti-aspergillus and so on.Conclusion:The Gelsemium has a good medicinal prospect,for the development of clinical application of drugs to provide a reference.
Objective:The Gelsemium widespread in our country folk therapeutic range,such as tumors,pain,rheumatoid arthritis and so on.However,when accidental poisoning occasionally occurred,this is all the more urgent needs to know its modern function and its clinical application fields.Methods:With the development of modern research and pharmacological research experiments,its effect has been further defined,particularly in the treatment of tumors and pain.The purpose of this paper reviewing many literature is to discuss the modern application of Gelsemium elegans,especially in anti tumor and pains research.Results:The Gelsemium has obvious anti-tumor,analgesic effect,anti-anxiety,repair radiation damage,radiation sensitization,hematopoietic protection,anti-inflammatory,anti-aspergillus and so on.Conclusion:The Gelsemium has a good medicinal prospect,for the development of clinical application of drugs to provide a reference.
引文
[1]易金娥,袁慧.钩吻毒素的研究进展[J].湖南环境生物职业技术学院学报,2002,8(4):26-30.
[2]龙军标,周金森,梁志轩.一起误食钩吻引起家庭性食物中毒的调查分析[J].实用预防医学,2013,20(12):1472-1473.
[3]温金星.钩吻中毒18例临床分析[J].中西医结合与祖国医学,2013,17(28):3764-3765.
[4]冯时茵,粟建明,侯惠婵,等.钩吻生物碱成分的薄层色谱研究[J].中药新药与临床药理,2013,24(1):77-80
[5]XU Y K,YANG L,LIAO S G,et al.Koumine,Humantenine,and Yohimbane Alkaloids from Gelsemium elegans[J].Journal of Natural Products,2015,78:1511-1517.
[6]ZHANG J Y,WANG Y X.Gelsemium analgesia and the spinal glycine receptor/allopregnanolone pathway[J].Fitoterapia,2015,100:35-43.
[7]Jeng Y M,Peng S Y,Lin C Y,et al.Over-expression and amplification of Aurora-A in hepatocellular carcinoma[J].Clin Cancer Res,2004,10(6):2065-2071.
[8]张兰兰,林敬明,吴忠.钩吻化学成分与药理研究进展[J].中药材,2003,26(6):451-453.
[9]王河山,吴水生.钩吻的资源调查及品质评价[D].福州:福建中医药大学,2016:1-84.
[10]辛任升,刘宇,张超,等.复方苦豆子灌注液总生物碱含量测定方法的建立[J].动物医学进展,2014,35(12):89-92.
[11]肖洒,伍勇,黄亚军,等.不同溶剂提取的钩吻粗提取物中成分含量的测定[J].动物医学进展,2016(6):72-76.
[12]吴达荣,秦瑞,蔡晶,等.钩吻素子抗肿瘤作用研究[J].中药药理与临床,2006,22(5):6-8.
[13]黄静,苏燕评,俞昌喜,等.钩吻生物碱化合物体外抗消化系统肿瘤的活性[J].海峡药学,2010,22(3):197-200.
[14]黄静,许盈,俞昌喜,等.钩吻生物碱化合物抗肿瘤效应及其诱导凋亡作用[J].海峡药学,2014,26(10):19-23.
[15]王海波,孙晓雪,邓志钦,等.钩吻总碱对肝癌细胞氯通道的激活作用[J].中国药理学通报,2015,31(11):1529-1535.
[16]高明雅,沈伟哉,吴颜晖,等.钩吻生物碱单体对肝癌细胞体外抑制作用机制的初步研究[J].中药材,2012,35(3):438-442
[17]蔡晶,雷林生,迟德彪.钩吻素子对小鼠H22实体瘤抑制作用的实验研究[J].南方医科大学学报,2009,29(9):1851-1852,1856.
[18]ZHANG X H,CHEN Y,GAO B,et al.Apoptotic Effect of Koumine on Human Breast Cancer Cells and the Mechanism Involved[J].Cell Biochem Biophys,2015,72:411-416.
[19]梁维君,安飞云,曾明.钩吻提取液对HL-60细胞生长增殖和细胞周期的影响[J].湖南师范大学学报(医学版),2004,1(1):39-43.
[20]丁建农,安飞云,曾明.钩吻提取液对Hela细胞生长增殖和细胞周期的影响[J].中国现代医学杂志,2005,15(2):230-232.
[21]迟德彪,雷林生,金宏,等.钩吻素子体外诱导人结肠腺癌Lo Vo细胞凋亡的实验研究[J].第一军医大学学报,2003,23(9):911-913.
[22]XV Y,QIU H Q,LIU H,et al.Effects of koumine,an alkaloid of Gelsemium elegans Benth on inflammatory and neuropathic pain models and possible mechanism with allopregnanolone[J].Pharmacology.Biochemistry and Behavior,2012,101:504-514.
[23]LIU M,SHEN J,LIU H,et al.Gelsenicine from Gelsemium elegans Attenuates Neuropathic and Inflammatory Pain in Mice[J].Biol.Pharm.Bull,2011,34(12):1877-1880.
[24]丘宏强,俞昌喜.钩吻素子抗神经病理性疼痛作用与脊髓神经活性甾体别孕烯醇酮的关系[D].福州:福建医科大学,2013.
[25]李苏平,许盈,凌倩,等.钩吻素子抗外周神经损伤致神经病理性疼痛中自发痛的效应[J].福建医科大学学报,2013,47(4):204-209.
[26]LING Q,LIU M,WU M X,et al.Anti-allodynic and Neuroprotective Effects of Koumine,a Benth Alkaloid,in a Rat Model of Diabetic Neuropathy[J].Biol.Pharm.Bull,2014,37(5):858-864
[27]LIU M,HUANG H H,YANG J,et al.The active alkaloids of Gelsemium elegans Benth.are potent anxiolytics[J].Chinese Journal of Pharmacology and Toxicology,2013,225(4):839-851.
[28]黄慧慧,刘铭,陈超杰,等.钩吻素子对大鼠焦虑行为的影响[J].西北药学杂志,2014,29(6):593-595.
[29]王坤,肖艳芬,余晓玲.钩吻对小鼠急性辐射损伤的保护作用[J].中华放射医学与防护杂志,2002,22(2):111-112.
[30]陆健敏,齐子荣,刘国廉,等.钩吻碱注射液对肿瘤细胞增殖能力的影响[J].癌症,1990,9(6):472-474.
[31]王坤,肖健,黄燕.钩吻对小鼠造血功能的影响[J].广西中医药,2000,23(6):48-50.
[32]杨渐,蔡宏达,陈泽鸿,等.钩吻素子对小鼠佐剂性关节炎的治疗作用[J].福建医科大学学报,2016,50(4):217-221.
[33]赵志常,蔡宜朋,吴水生.钩吻活性成分的提取分离及其体外抗真菌作用初步研究[J].海峡药学,2016(5):18-20.
[34]罗琼,郝近大.断肠草的本草考证[J].时珍国医国药,2007,18,特刊:54-57
[35]代佳娣,张卓亿,孙志良,等.钩吻药理学作用研究进展[J].中兽医医药杂志,2016,2(8):30-33.
[36]许盈,郑宓,李苏平,等.钩吻素子在大鼠体内的药物代谢动力学及组织分布[J].福建医科大学学报,2013,47(4):199-203
[37]杨洪尚,刘杰.骗服钩吻后刺伤颈总动脉致死亡l例[J].中国法医学,2016,31(1):93.
[38]王英豪,吴水生.毒性中药钩吻配伍玉叶金花减毒机制研究[D].福建:福建中医药大学,2016:1-87.
[39]邢东梅,曹燕,伍勇,等.钩吻生物碱急性毒性研究[J].中兽医医药杂志,2015,5:52-54
[40]李磊,曾洋.利用钩吻自杀的法医学分析1例[J].广东公安科技,2015,23(2):74-75.
[41]廖达林,张伟.机械通气并血液灌流治疗重度钩吻中毒的效果[J].齐鲁医学杂志,2015,30(5):564-566
[2]龙军标,周金森,梁志轩.一起误食钩吻引起家庭性食物中毒的调查分析[J].实用预防医学,2013,20(12):1472-1473.
[3]温金星.钩吻中毒18例临床分析[J].中西医结合与祖国医学,2013,17(28):3764-3765.
[4]冯时茵,粟建明,侯惠婵,等.钩吻生物碱成分的薄层色谱研究[J].中药新药与临床药理,2013,24(1):77-80
[5]XU Y K,YANG L,LIAO S G,et al.Koumine,Humantenine,and Yohimbane Alkaloids from Gelsemium elegans[J].Journal of Natural Products,2015,78:1511-1517.
[6]ZHANG J Y,WANG Y X.Gelsemium analgesia and the spinal glycine receptor/allopregnanolone pathway[J].Fitoterapia,2015,100:35-43.
[7]Jeng Y M,Peng S Y,Lin C Y,et al.Over-expression and amplification of Aurora-A in hepatocellular carcinoma[J].Clin Cancer Res,2004,10(6):2065-2071.
[8]张兰兰,林敬明,吴忠.钩吻化学成分与药理研究进展[J].中药材,2003,26(6):451-453.
[9]王河山,吴水生.钩吻的资源调查及品质评价[D].福州:福建中医药大学,2016:1-84.
[10]辛任升,刘宇,张超,等.复方苦豆子灌注液总生物碱含量测定方法的建立[J].动物医学进展,2014,35(12):89-92.
[11]肖洒,伍勇,黄亚军,等.不同溶剂提取的钩吻粗提取物中成分含量的测定[J].动物医学进展,2016(6):72-76.
[12]吴达荣,秦瑞,蔡晶,等.钩吻素子抗肿瘤作用研究[J].中药药理与临床,2006,22(5):6-8.
[13]黄静,苏燕评,俞昌喜,等.钩吻生物碱化合物体外抗消化系统肿瘤的活性[J].海峡药学,2010,22(3):197-200.
[14]黄静,许盈,俞昌喜,等.钩吻生物碱化合物抗肿瘤效应及其诱导凋亡作用[J].海峡药学,2014,26(10):19-23.
[15]王海波,孙晓雪,邓志钦,等.钩吻总碱对肝癌细胞氯通道的激活作用[J].中国药理学通报,2015,31(11):1529-1535.
[16]高明雅,沈伟哉,吴颜晖,等.钩吻生物碱单体对肝癌细胞体外抑制作用机制的初步研究[J].中药材,2012,35(3):438-442
[17]蔡晶,雷林生,迟德彪.钩吻素子对小鼠H22实体瘤抑制作用的实验研究[J].南方医科大学学报,2009,29(9):1851-1852,1856.
[18]ZHANG X H,CHEN Y,GAO B,et al.Apoptotic Effect of Koumine on Human Breast Cancer Cells and the Mechanism Involved[J].Cell Biochem Biophys,2015,72:411-416.
[19]梁维君,安飞云,曾明.钩吻提取液对HL-60细胞生长增殖和细胞周期的影响[J].湖南师范大学学报(医学版),2004,1(1):39-43.
[20]丁建农,安飞云,曾明.钩吻提取液对Hela细胞生长增殖和细胞周期的影响[J].中国现代医学杂志,2005,15(2):230-232.
[21]迟德彪,雷林生,金宏,等.钩吻素子体外诱导人结肠腺癌Lo Vo细胞凋亡的实验研究[J].第一军医大学学报,2003,23(9):911-913.
[22]XV Y,QIU H Q,LIU H,et al.Effects of koumine,an alkaloid of Gelsemium elegans Benth on inflammatory and neuropathic pain models and possible mechanism with allopregnanolone[J].Pharmacology.Biochemistry and Behavior,2012,101:504-514.
[23]LIU M,SHEN J,LIU H,et al.Gelsenicine from Gelsemium elegans Attenuates Neuropathic and Inflammatory Pain in Mice[J].Biol.Pharm.Bull,2011,34(12):1877-1880.
[24]丘宏强,俞昌喜.钩吻素子抗神经病理性疼痛作用与脊髓神经活性甾体别孕烯醇酮的关系[D].福州:福建医科大学,2013.
[25]李苏平,许盈,凌倩,等.钩吻素子抗外周神经损伤致神经病理性疼痛中自发痛的效应[J].福建医科大学学报,2013,47(4):204-209.
[26]LING Q,LIU M,WU M X,et al.Anti-allodynic and Neuroprotective Effects of Koumine,a Benth Alkaloid,in a Rat Model of Diabetic Neuropathy[J].Biol.Pharm.Bull,2014,37(5):858-864
[27]LIU M,HUANG H H,YANG J,et al.The active alkaloids of Gelsemium elegans Benth.are potent anxiolytics[J].Chinese Journal of Pharmacology and Toxicology,2013,225(4):839-851.
[28]黄慧慧,刘铭,陈超杰,等.钩吻素子对大鼠焦虑行为的影响[J].西北药学杂志,2014,29(6):593-595.
[29]王坤,肖艳芬,余晓玲.钩吻对小鼠急性辐射损伤的保护作用[J].中华放射医学与防护杂志,2002,22(2):111-112.
[30]陆健敏,齐子荣,刘国廉,等.钩吻碱注射液对肿瘤细胞增殖能力的影响[J].癌症,1990,9(6):472-474.
[31]王坤,肖健,黄燕.钩吻对小鼠造血功能的影响[J].广西中医药,2000,23(6):48-50.
[32]杨渐,蔡宏达,陈泽鸿,等.钩吻素子对小鼠佐剂性关节炎的治疗作用[J].福建医科大学学报,2016,50(4):217-221.
[33]赵志常,蔡宜朋,吴水生.钩吻活性成分的提取分离及其体外抗真菌作用初步研究[J].海峡药学,2016(5):18-20.
[34]罗琼,郝近大.断肠草的本草考证[J].时珍国医国药,2007,18,特刊:54-57
[35]代佳娣,张卓亿,孙志良,等.钩吻药理学作用研究进展[J].中兽医医药杂志,2016,2(8):30-33.
[36]许盈,郑宓,李苏平,等.钩吻素子在大鼠体内的药物代谢动力学及组织分布[J].福建医科大学学报,2013,47(4):199-203
[37]杨洪尚,刘杰.骗服钩吻后刺伤颈总动脉致死亡l例[J].中国法医学,2016,31(1):93.
[38]王英豪,吴水生.毒性中药钩吻配伍玉叶金花减毒机制研究[D].福建:福建中医药大学,2016:1-87.
[39]邢东梅,曹燕,伍勇,等.钩吻生物碱急性毒性研究[J].中兽医医药杂志,2015,5:52-54
[40]李磊,曾洋.利用钩吻自杀的法医学分析1例[J].广东公安科技,2015,23(2):74-75.
[41]廖达林,张伟.机械通气并血液灌流治疗重度钩吻中毒的效果[J].齐鲁医学杂志,2015,30(5):564-566