巴戟天颗粒治疗脾肾亏虚型遗忘型轻度认知损害的疗效分析
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摘要
巴戟天颗粒治疗脾肾亏虚型遗忘型轻度认知损害具有一定的优势,对60例脾肾亏虚型遗忘型轻度认知损害患者分为巴戟天颗粒治疗组(观察组)和尼莫地平片治疗组(对照组),比较两组治疗前后中西医疗效及同型半胱氨酸(Hcy)、纤维蛋白原(FIB)水平。其中,观察组总有效率高于对照组,两组患者治疗3个月后Hcy、FIB水平较治疗前均明显降低,且治疗3个月后两组比较,观察组Hcy、FIB水平降低较对照组更明显(P<0.05)。巴戟天颗粒治疗脾肾亏虚型遗忘型轻度认知损害有确切疗效,值得临床推广应用。
Baqitian granule has certain advantages in the treatment of spleen-kidney deficiency type and amnestic mild cognitive impairment. 60 patients with mild cognitive impairment of spleen-kidney deficiency type are enrolled in Baqitian granule treatment( observation group) and nimodipine( control group),which was compared between the two groups before and after treatment,and the levels of homocysteine( Hcy) and fibrinogen( FIB) were compared. Among them,the total effective rate of the observation group was higher than that of the control group. The levels of Hcy and FIB in the two groups were significantly lower than those before treatment. After 3 months of treatment,the levels of Hcy and FIB in the observation group were lower than those in the control group. The group was more obvious,and the above differences were statistically significant( P<0.05). Baqitian granule has a definite curative effect on the treatment of spleen-kidney deficiency type and amnestic mild cognitive impairment,which is worthy of clinical application.
Baqitian granule has certain advantages in the treatment of spleen-kidney deficiency type and amnestic mild cognitive impairment. 60 patients with mild cognitive impairment of spleen-kidney deficiency type are enrolled in Baqitian granule treatment( observation group) and nimodipine( control group),which was compared between the two groups before and after treatment,and the levels of homocysteine( Hcy) and fibrinogen( FIB) were compared. Among them,the total effective rate of the observation group was higher than that of the control group. The levels of Hcy and FIB in the two groups were significantly lower than those before treatment. After 3 months of treatment,the levels of Hcy and FIB in the observation group were lower than those in the control group. The group was more obvious,and the above differences were statistically significant( P<0.05). Baqitian granule has a definite curative effect on the treatment of spleen-kidney deficiency type and amnestic mild cognitive impairment,which is worthy of clinical application.
引文
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[10]赵雅梅,史宏伟,葛亚力,等.七氟醚对心脏瓣膜置换术患者rSO2和术后认知功能的影响[J].江苏大学学报(医学版),2016,26(6):515-8.
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[13]石琳,吴成翰.轻度认知功能障碍的中西医治疗现况[J].实用心脑肺血管病杂志,2014,22(3):155-8.
[14]陈地灵,张鹏,林励,等.巴戟天低聚糖对Aβ_(25-35)致拟痴呆模型大鼠学习记忆障碍的影响[J].中国药理学通报,2013,29(2):271-6.
[15]张春霞,郭俊和,陈云波,等.石菖蒲活性成分对双转基因小鼠APP及神经突触超微结构的影响[J].中药新药与临床药理,2014,25(1):18-23.
[16]杨贤志,陈勤,陈庆林,等.远志皂苷对β淀粉样蛋白片段1-40诱导PC12细胞凋亡的抑制作用[J].中国药理学与毒理学杂志,2013,27(3):379-84.
[2]秦虹云,郁东海,郭祎,等.温阳益气活血方足浴对社区轻度认知功能障碍患者炎症因子的影响[J].河北中医,2017,39(8):1179-82.
[3]黄磊,田国强,蒋海潮,等.利培酮联合六味地黄丸对老年精神分裂患者血清同型半胱氨酸、脑源性神经营养因子及认知功能影响研究[J].中华中医药学刊,2016,34(10):2485-8.
[4]陈园园,刘霄霄,刘涛,等.针药结合对轻度认知障碍患者痰浊阻滞症候评分影响的临床研究[J].针灸临床杂志,2016,32(3):16-8.
[5]孙远征,李书霖,祝鹏宇,等.原络通经针法结合口服安理申对轻度血管性认知障碍患者记忆影响的临床观察[J].中医药信息,2016,33(3):109-11.
[6]韩丽,李鹏超,张志敏,等.血府逐瘀胶囊联合脑苷肌肽治疗血管性痴呆的疗效观察[J].现代药物与临床,2016,31(10):1591-4.
[7]时晶,倪敬年,田金洲,等.中国痴呆诊疗指南---轻度认知损害诊疗指南解读[J].中国医学前沿杂志(电子版),2012,4(10):67-70.
[8]郑筱萸.中药新药临床研究指导原则(试行)[M].中国医药科技出版社,2002.
[9]吴丹,杨晓明,陈智.不同麻醉诱导方法对老年腰椎手术患者早期术后认知功能障碍发生率的影响[J].空军医学杂志,2017,33(2):121-5.
[10]赵雅梅,史宏伟,葛亚力,等.七氟醚对心脏瓣膜置换术患者rSO2和术后认知功能的影响[J].江苏大学学报(医学版),2016,26(6):515-8.
[11]封海霞,李国宏,李梦婷,等.延续护理对卒中后非痴呆型认知障碍患者的影响[J].现代医学,2016,44(6):853-6.
[12]戴婷婷,田绍文.阿尔兹海默病靶向治疗研究进展[J].中南医学科学杂志,2015,43(4):452-6.
[13]石琳,吴成翰.轻度认知功能障碍的中西医治疗现况[J].实用心脑肺血管病杂志,2014,22(3):155-8.
[14]陈地灵,张鹏,林励,等.巴戟天低聚糖对Aβ_(25-35)致拟痴呆模型大鼠学习记忆障碍的影响[J].中国药理学通报,2013,29(2):271-6.
[15]张春霞,郭俊和,陈云波,等.石菖蒲活性成分对双转基因小鼠APP及神经突触超微结构的影响[J].中药新药与临床药理,2014,25(1):18-23.
[16]杨贤志,陈勤,陈庆林,等.远志皂苷对β淀粉样蛋白片段1-40诱导PC12细胞凋亡的抑制作用[J].中国药理学与毒理学杂志,2013,27(3):379-84.