眼镜蛇毒因子抑制小鼠疼痛反应
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摘要
<正>疼痛是诸多病征共有的症状,是动物的神经系统对伤害刺激的感觉。疼痛研究的焦点在于疼痛发生的机制以及干预治疗的策略和药物研究~([1-2])。补体旁路激活会导致炎症和组织损伤~([3])。有研究表明,补体与某些神经病理性疼痛关系密切~([4-5]),但其与非神经性疼痛的关系尚不清楚。本研究用眼镜蛇毒因子(cobra venom factor,CVF)特异抑制补体旁路途径,观察小鼠对疼痛的反应。1材料与方法
引文
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[7] 孙黔云,叶巧玲,闫银萍.小鼠血清补体替代途径溶血活性测定的新方法[J].中国药理学通报,2011,27(11):1619-22.[7] Sun Q Y,Ye Q L,Yan Y P.A new method for measurement of the alternative pathway activity of mouse serum complement[J].Chin Pharmacol Bull,2011,27(11):1619-22.
[2] Colloca L,Ludman T,Baron R,et al.Neuropathic pain[J].Nat Rev Dis Primers,2017,3:17002.
[3] Ricklin D,Reis E S,Lambris D.Complement in disease:a defence system turning offensive[J].Nat Rev Nephrol,2016,12(7):383-401.
[4] Nie F C,Wang J B,Su D,et al.Abnormal activation of complement C3 in the spinal dorsal horn is closely associated with progression of neuropathic pain[J].Int J Mol Med,2013,31(6):1333-42.
[5] Levin M E,Jin J G,Ji R R,et al.Complement activation in the peripheral nervous system following the spinal nerve ligation model of neuropathic pain[J].Pain,2008,137(1):182-201.
[6] 朱芳娟,李敏,杨铭,等.槲皮素及其衍生物对补体旁路激活致内皮细胞炎症反应的干预作用[J].中国药理学通报,2018,34(11):1539-43.[6] Zhu F J,Li M,Yang M,et al.Effect of quercetin and its derivatives on inflammatory response of endothelial cells induced by activation of complement alternative pathway[J].Chin Pharmacol Bull,2018,34(11):1539-43.
[7] 孙黔云,叶巧玲,闫银萍.小鼠血清补体替代途径溶血活性测定的新方法[J].中国药理学通报,2011,27(11):1619-22.[7] Sun Q Y,Ye Q L,Yan Y P.A new method for measurement of the alternative pathway activity of mouse serum complement[J].Chin Pharmacol Bull,2011,27(11):1619-22.