肿瘤转移相关基因在子宫内膜异位症发生发展中的作用
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摘要
子宫内膜异位症致病机制尚不清楚,虽为良性疾病,却具有增生、浸润、远处转移及极易复发等恶性行为,其防治工作一直是妇科领域难题。肿瘤转移相关基因表达的蛋白在细胞增生、凋亡及黏附方面发挥了重要作用,与EMS的发生和发展可能存在关联。本文将综述有关两者关联的文献,从基因水平归纳EMS诊疗相关的分子标志物,探讨EMS的辅助诊断和临床治疗的新思路。
Because the pathogenic mechanism of endometriosis is not clear, even if endometriosis is a benign disease, but it has some malignant behavior, such as proliferation, infiltration, distant metastasis, and easy to relapse. its prevention and control has always been a difficult problem in the field of gynecology. The protein expression of genes related to tumor metastasis played important roles in cell proliferation, apoptosis, and inadhesion, and we speculate that the occurrence and development of EMS may have an association with those genes. Therefore, this article will review relevant literatures, to conclude t biomarkers from the gene level, and find new way for diagnosis and treatment of EMS.
Because the pathogenic mechanism of endometriosis is not clear, even if endometriosis is a benign disease, but it has some malignant behavior, such as proliferation, infiltration, distant metastasis, and easy to relapse. its prevention and control has always been a difficult problem in the field of gynecology. The protein expression of genes related to tumor metastasis played important roles in cell proliferation, apoptosis, and inadhesion, and we speculate that the occurrence and development of EMS may have an association with those genes. Therefore, this article will review relevant literatures, to conclude t biomarkers from the gene level, and find new way for diagnosis and treatment of EMS.
引文
[1]Pan Y, Tong S, Cui R, et al. Long Non-Coding MALAT1 Functions as a Competing Endogenous RNA to Regulate Vimentin Expression by Sponging miR-30a-5p in Hepatocellular Carcinoma[J].Cell Physiol Biochem,2018,50(1):108-120..
[2]Li X, Liu X, Guo SW. Clinical profiles of 710 premenopausal women with adenomyosis who underwent hysterectomy[J]. J Obstet Gynaecol Res,2014,40(2):485-494.
[3]Fabbri R, Vicenti R, Paradisi R,et al.Transplantation of cryopreserved ovarian tissue in a patient affected by metastatic struma ovarii and endometriosis[J].Gynecol Endocrinol, 2018, 34(7):558-562.5.
[4]Perlman S, Kjer JJ.Ovarian damage due to cyst removal:a comparison of endometriomas and dermoid cysts[J].Acta Obstet Gynecol Scand,2016,95(3):285-290.
[5]Imesch P, Fink D. Endometriosis Update 2016[J]. Praxis(Bern 1994),2016,105(5):253-257.
[6]Sanchez AM, Somigliana E, Vercellini P, et al. Endometriosis as a detrimental condition for granulosa cell steroidogenesis and development:From molecular alterations to clinical impact[J].J Steroid Biochem Mol Biol,2016,155(Pt A):35-46.
[7]舒登兵.36例腹壁子宫内膜异位症临床病理分析[J].齐齐哈尔医学院学报,2011,32(13):2134.
[8]Yeo SG, Won YS, Kim SH, et al. Differences in C-type lectin receptors and their adaptor molecules in the peritoneal fluid of patients with endometriosis and gynecologic cancers[J]. Int J Med Sci, 2018, 15(4):411-416.
[9]陈瀚勋,邱懿德,方洁莹,等.彩色多普勒超声对腹壁子宫内膜异位症的诊断价值分析[J].医学理论与实践,2015,28(12):1644-1645.
[10]Juneja M, Kobelt D, Walther W, et al. Statin and rottlerin small-molecule inhibitors restrict colon cancer progression and metastasis via MACC1[J].PLoS Bio,2017,15(6):e2000784.
[11]滕正华.手术与手术联合药物治疗腹壁子宫内膜异位症的临床疗效比较[J].临床合理用药,2015,8(6):87-88.
[12]成健,陈芷青,黄森,等.补片用于腹壁切口子宫内膜异位症17例临床分析[J].中国妇产科临床杂志,2013,14(4):347-348.
[13]Selcuk I, Bozdag G. Recurrence of endometriosis; risk factors, mechanisms and biomarkers; review of the literature[J].J Turk Ger Gynecol Assoc,2013,14(2):98-103.
[14]Derouich S,Attia L,Slimani O,et al. Medical treatment of endometriosis[J].Tunis Med,2015, 93(7):407-412.
[15]Xiang Y, Zhang Y, Tang Y,et al. MALAT1 Modulates TGF-beta1-Induced Endothelial-to-Mesenchymal Transition through Downregulation of miR-145[J]. Cell Physiol Biochem,2017, 42(1):357-372.
[16]Jen J, Tang YA, Lu YH, et al. Oct4 transcriptionally regulates the expression of long non-coding RNAs NEAT1 and MALAT1 to promote lung cancer progression[J]. Mol Cancer,2017, 16(1):104.
[17]Kim W, Kim M, Jho EH. Wnt/b-catenin signalling:from plasma membrane to nucleus[J]. Biochem J, 2013, 450(1):9-21.
[18]Baum B,Georgiou M.Dynamics of adherens junctions in epithelialestablishm ent,maintenance,andremodeling[J].JCellBiol, 2011,192(6):907-17.
[19]Wang G, Wang S, Li C. MiR-183 overexpression inhibits tumorigenesis and enhances DDP-induced cytotoxicity by targeting MTA1 in nasopharyngeal carcinoma[J]. Tumour Biol,2017, 39(6):1010428317703825.
[20]Guo T, Zhao S, Wang P, et al.YB-1 regulates tumor growth by promoting MACC1/c-Met pathway in human lung adenocarcinoma[J]. Oncotarget,2017,8(29):48110-48125.
[21]Bouquet De,Joliniere J, Ayoubi JM, et al.Endometriosis:a new cellular and molecular genetic approach for understanding the pathogenesis and evolutivity[J]. Front Surg, 2014, 1:16.
[22]郑婷婷,刘义,于岚,等.靶向siRNA阻断Wnt/b-catenin信号通路对子宫内膜异位症裸鼠模型异位子宫内膜VEGF和MMP-9表达的影响[J].华中科技大学学报:医学版,2011,40(1):22-27.
[23]Huang S,Qin J,Chen J,et al.Impact of laparoscopy on the biological behavior and gene expression of endometrial adenocarcinoma cells[J].Gynecol Endocrinol,2017,33(11):899-903.
[24]Prasad R,Katiyar SK.Ultraviolet radiation-induced inflammation activates b-catenin signaling in mouse skin and skin tumors[J].Int J Oncol,2014,44(4):1199-206.
[25]Walsh LA,Alvarez MJ,Sabio EY,et al.An Integrated Systems Biology Approach Identifies TRIM25 as a Key Determinant of Breast Cancer Metastasis[J].Cell Rep,2017,20(7):1623-1640.
[26]Joshi AD, Hossain E,Elferink CJ. Epigenetic Regulation by Agonist-Specific Aryl Hydrocarbon Receptor Recruitment of Metastasis-Associated Protein2 Selectively Induces Stanniocalcin 2 Expression[J].Mol Pharmacol,2017,92(3):366-374.
[27]Hu M,Wang R,Li X,et al.LncRNA MALAT1 is dysregulated in diabetic nephropathy and involved in high glucose-induced podocyte injury via its interplay with beta-catenin[J].J Cell Mol Med,2017,21(11):2732-2747.
[28]Li S, Ma F, Jiang K, et al. Long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 promotes lung adenocarcinoma by directly interacting with specificity protein 1[J]. Cancer Sci,2018, 109(5):1346-1356.
[29]F i n e g a nK G, P e r e z-M a d r i g a lD, H i t c h i nJ R, e ta l. E R K 5i sac r i t i c a l m e d i a t o r o f i n f l a m m a t i o n-d r i v e n c a n c e r[J].CancerRes,2015,75(4):742-53.
[30]Xia C, Liang S, He Z, et al. Metformin, a first-line drug for type 2 diabetes mellitus, disrupts the MALAT1/miR-142-3p sponge to decrease invasion and migration in cervical cancer cells[J]. Eur J Pharmacol,2018, 830:59-67.
[31]Lee MH, Na H, Kim EJ, et al. Poly(ADP-ribosyl)ation of p53 induces genespecific transcriptional repression of MTA1[J]. Oncogene, 2012, 31(49):5099-5107.
[32]Liu K, Huang J, Ni J, et al. MALAT1 promotes osteosarcoma development by regulation of HMGB1 via mi R-142-3p and mi R-129-5p[J].Cell Cycle,2017,16(6):578-587.
[33]Xiong B, Lei X, Zhang L,et al. miR-103 regulates triple negative breast cancer cells migration and invasion through targeting olfactomedin 4[J].Biomed Pharmacother,2017, 89:1401-1408.
[34]Lu AQ, Lv B, Qiu F, et al.Upregulation of miR-137 reverses sorafenib resistance and cancer-initiating cell phenotypes by degrading ANT2 in hepatocellular carcinoma. Oncol Rep,2017, 37(4):2071-2078.
[35]Di Spiezio Sardo A, Florio P, Fernandez LM, et al. The potential role of endometrial nerve fibers in the pathogenesis of pain during endometrial biopsy at office hysteroscopy[J]. Reprod Sci, 2015, 22(1):124-131.
[36]Yang R, Zheng G, Ren D, et al. The clinical significance and biological function of tropomyosin 4 in colon cancer[J]. Biomed Pharmacother,2018,101:1-7.
[37]Chen J, Ding J, Wang Z,et al. Identification of downstream metastasisassociated target genes regulated by LSD1 in colon cancer cells[J].Oncotarget, 2017, 8(12):19609-19630.
[38]Dhar S, Kumar A, Gomez CR, et al. MTA1-activated Epi-microRNA-22regulates E-cadherin and prostate cancer invasiveness[J]. FEBS Lett,2017,591(6):924-933.
[39]Xie ZT, Chen C, Zhang SH, et al. Effect of leukocyte filtration on the P-selectin expression of apheresis platelets[J]. Genet Mol Res, 2015,14(2):5979-5985.
[40]Pavlidis ET, Pavlidis TE. Current Molecular and Genetic Aspects of Pancreatic Cancer, the Role of Metastasis Associated Proteins(MTA):A Review[J]. J Invest Surg,2018, 31(1):54-66.
[41]Wu DW, Chen CY, Chu CL, et al. Paxillin confers resistance to tyrosine kinase inhibitors in EGFR-mutant lung cancers via modulating BIM and Mcl-1 protein stability[J]. Oncogene,2016, 35(5):621-630.
[42]Zhao CJ, Du SK, Dang XB, et al. Expression of Paxillin is Correlated with Clinical Prognosis in Colorectal Cancer Patients[J]. Med Sci Monit,2015,21:1989-1995.
[43]Pavlidis ET, Pavlidis TE. Current Molecular and Genetic Aspects of Pancreatic Cancer, the Role of Metastasis Associated Proteins(MTA):A Review[J]. J Invest Surg,2018, 31(1):54-66.
[44]Huang CC, Wu DW, Lin PL, et al. Paxillin promotes colorectal tumor invasion and poor patient outcomes via ERK-mediated stabilization of Bcl-2 protein by phosphorylation at Serine 87[J]. Oncotarget,2015, 6(11):8698-8708.
[2]Li X, Liu X, Guo SW. Clinical profiles of 710 premenopausal women with adenomyosis who underwent hysterectomy[J]. J Obstet Gynaecol Res,2014,40(2):485-494.
[3]Fabbri R, Vicenti R, Paradisi R,et al.Transplantation of cryopreserved ovarian tissue in a patient affected by metastatic struma ovarii and endometriosis[J].Gynecol Endocrinol, 2018, 34(7):558-562.5.
[4]Perlman S, Kjer JJ.Ovarian damage due to cyst removal:a comparison of endometriomas and dermoid cysts[J].Acta Obstet Gynecol Scand,2016,95(3):285-290.
[5]Imesch P, Fink D. Endometriosis Update 2016[J]. Praxis(Bern 1994),2016,105(5):253-257.
[6]Sanchez AM, Somigliana E, Vercellini P, et al. Endometriosis as a detrimental condition for granulosa cell steroidogenesis and development:From molecular alterations to clinical impact[J].J Steroid Biochem Mol Biol,2016,155(Pt A):35-46.
[7]舒登兵.36例腹壁子宫内膜异位症临床病理分析[J].齐齐哈尔医学院学报,2011,32(13):2134.
[8]Yeo SG, Won YS, Kim SH, et al. Differences in C-type lectin receptors and their adaptor molecules in the peritoneal fluid of patients with endometriosis and gynecologic cancers[J]. Int J Med Sci, 2018, 15(4):411-416.
[9]陈瀚勋,邱懿德,方洁莹,等.彩色多普勒超声对腹壁子宫内膜异位症的诊断价值分析[J].医学理论与实践,2015,28(12):1644-1645.
[10]Juneja M, Kobelt D, Walther W, et al. Statin and rottlerin small-molecule inhibitors restrict colon cancer progression and metastasis via MACC1[J].PLoS Bio,2017,15(6):e2000784.
[11]滕正华.手术与手术联合药物治疗腹壁子宫内膜异位症的临床疗效比较[J].临床合理用药,2015,8(6):87-88.
[12]成健,陈芷青,黄森,等.补片用于腹壁切口子宫内膜异位症17例临床分析[J].中国妇产科临床杂志,2013,14(4):347-348.
[13]Selcuk I, Bozdag G. Recurrence of endometriosis; risk factors, mechanisms and biomarkers; review of the literature[J].J Turk Ger Gynecol Assoc,2013,14(2):98-103.
[14]Derouich S,Attia L,Slimani O,et al. Medical treatment of endometriosis[J].Tunis Med,2015, 93(7):407-412.
[15]Xiang Y, Zhang Y, Tang Y,et al. MALAT1 Modulates TGF-beta1-Induced Endothelial-to-Mesenchymal Transition through Downregulation of miR-145[J]. Cell Physiol Biochem,2017, 42(1):357-372.
[16]Jen J, Tang YA, Lu YH, et al. Oct4 transcriptionally regulates the expression of long non-coding RNAs NEAT1 and MALAT1 to promote lung cancer progression[J]. Mol Cancer,2017, 16(1):104.
[17]Kim W, Kim M, Jho EH. Wnt/b-catenin signalling:from plasma membrane to nucleus[J]. Biochem J, 2013, 450(1):9-21.
[18]Baum B,Georgiou M.Dynamics of adherens junctions in epithelialestablishm ent,maintenance,andremodeling[J].JCellBiol, 2011,192(6):907-17.
[19]Wang G, Wang S, Li C. MiR-183 overexpression inhibits tumorigenesis and enhances DDP-induced cytotoxicity by targeting MTA1 in nasopharyngeal carcinoma[J]. Tumour Biol,2017, 39(6):1010428317703825.
[20]Guo T, Zhao S, Wang P, et al.YB-1 regulates tumor growth by promoting MACC1/c-Met pathway in human lung adenocarcinoma[J]. Oncotarget,2017,8(29):48110-48125.
[21]Bouquet De,Joliniere J, Ayoubi JM, et al.Endometriosis:a new cellular and molecular genetic approach for understanding the pathogenesis and evolutivity[J]. Front Surg, 2014, 1:16.
[22]郑婷婷,刘义,于岚,等.靶向siRNA阻断Wnt/b-catenin信号通路对子宫内膜异位症裸鼠模型异位子宫内膜VEGF和MMP-9表达的影响[J].华中科技大学学报:医学版,2011,40(1):22-27.
[23]Huang S,Qin J,Chen J,et al.Impact of laparoscopy on the biological behavior and gene expression of endometrial adenocarcinoma cells[J].Gynecol Endocrinol,2017,33(11):899-903.
[24]Prasad R,Katiyar SK.Ultraviolet radiation-induced inflammation activates b-catenin signaling in mouse skin and skin tumors[J].Int J Oncol,2014,44(4):1199-206.
[25]Walsh LA,Alvarez MJ,Sabio EY,et al.An Integrated Systems Biology Approach Identifies TRIM25 as a Key Determinant of Breast Cancer Metastasis[J].Cell Rep,2017,20(7):1623-1640.
[26]Joshi AD, Hossain E,Elferink CJ. Epigenetic Regulation by Agonist-Specific Aryl Hydrocarbon Receptor Recruitment of Metastasis-Associated Protein2 Selectively Induces Stanniocalcin 2 Expression[J].Mol Pharmacol,2017,92(3):366-374.
[27]Hu M,Wang R,Li X,et al.LncRNA MALAT1 is dysregulated in diabetic nephropathy and involved in high glucose-induced podocyte injury via its interplay with beta-catenin[J].J Cell Mol Med,2017,21(11):2732-2747.
[28]Li S, Ma F, Jiang K, et al. Long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 promotes lung adenocarcinoma by directly interacting with specificity protein 1[J]. Cancer Sci,2018, 109(5):1346-1356.
[29]F i n e g a nK G, P e r e z-M a d r i g a lD, H i t c h i nJ R, e ta l. E R K 5i sac r i t i c a l m e d i a t o r o f i n f l a m m a t i o n-d r i v e n c a n c e r[J].CancerRes,2015,75(4):742-53.
[30]Xia C, Liang S, He Z, et al. Metformin, a first-line drug for type 2 diabetes mellitus, disrupts the MALAT1/miR-142-3p sponge to decrease invasion and migration in cervical cancer cells[J]. Eur J Pharmacol,2018, 830:59-67.
[31]Lee MH, Na H, Kim EJ, et al. Poly(ADP-ribosyl)ation of p53 induces genespecific transcriptional repression of MTA1[J]. Oncogene, 2012, 31(49):5099-5107.
[32]Liu K, Huang J, Ni J, et al. MALAT1 promotes osteosarcoma development by regulation of HMGB1 via mi R-142-3p and mi R-129-5p[J].Cell Cycle,2017,16(6):578-587.
[33]Xiong B, Lei X, Zhang L,et al. miR-103 regulates triple negative breast cancer cells migration and invasion through targeting olfactomedin 4[J].Biomed Pharmacother,2017, 89:1401-1408.
[34]Lu AQ, Lv B, Qiu F, et al.Upregulation of miR-137 reverses sorafenib resistance and cancer-initiating cell phenotypes by degrading ANT2 in hepatocellular carcinoma. Oncol Rep,2017, 37(4):2071-2078.
[35]Di Spiezio Sardo A, Florio P, Fernandez LM, et al. The potential role of endometrial nerve fibers in the pathogenesis of pain during endometrial biopsy at office hysteroscopy[J]. Reprod Sci, 2015, 22(1):124-131.
[36]Yang R, Zheng G, Ren D, et al. The clinical significance and biological function of tropomyosin 4 in colon cancer[J]. Biomed Pharmacother,2018,101:1-7.
[37]Chen J, Ding J, Wang Z,et al. Identification of downstream metastasisassociated target genes regulated by LSD1 in colon cancer cells[J].Oncotarget, 2017, 8(12):19609-19630.
[38]Dhar S, Kumar A, Gomez CR, et al. MTA1-activated Epi-microRNA-22regulates E-cadherin and prostate cancer invasiveness[J]. FEBS Lett,2017,591(6):924-933.
[39]Xie ZT, Chen C, Zhang SH, et al. Effect of leukocyte filtration on the P-selectin expression of apheresis platelets[J]. Genet Mol Res, 2015,14(2):5979-5985.
[40]Pavlidis ET, Pavlidis TE. Current Molecular and Genetic Aspects of Pancreatic Cancer, the Role of Metastasis Associated Proteins(MTA):A Review[J]. J Invest Surg,2018, 31(1):54-66.
[41]Wu DW, Chen CY, Chu CL, et al. Paxillin confers resistance to tyrosine kinase inhibitors in EGFR-mutant lung cancers via modulating BIM and Mcl-1 protein stability[J]. Oncogene,2016, 35(5):621-630.
[42]Zhao CJ, Du SK, Dang XB, et al. Expression of Paxillin is Correlated with Clinical Prognosis in Colorectal Cancer Patients[J]. Med Sci Monit,2015,21:1989-1995.
[43]Pavlidis ET, Pavlidis TE. Current Molecular and Genetic Aspects of Pancreatic Cancer, the Role of Metastasis Associated Proteins(MTA):A Review[J]. J Invest Surg,2018, 31(1):54-66.
[44]Huang CC, Wu DW, Lin PL, et al. Paxillin promotes colorectal tumor invasion and poor patient outcomes via ERK-mediated stabilization of Bcl-2 protein by phosphorylation at Serine 87[J]. Oncotarget,2015, 6(11):8698-8708.