生化益母汤对产后子宫复旧的促进作用研究
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摘要
目的:探讨生化益母汤对产后子宫复旧的促进作用。方法:选取2017年南京医科大学附属常州妇幼保健院收治的足月分娩患者,将100例自然分娩患者以随机数字表法分为观察1组和对照组1组,每组50例;将100例行剖宫产术患者以随机数字表法分为观察2组和对照2组,每组50例。对照1、2组患者给予缩宫素治疗,观察1、2组患者给予生化益母汤治疗。1个疗程后,比较观察组和对照组患者的恶露量、平均恶露持续时间、子宫复旧指标水平及不良反应发生情况的差异。结果:观察1组患者平均恶露持续时间明显短于对照1组,观察2组患者平均恶露持续时间明显短于对照2组,差异均有统计学意义(P<0.05)。观察1组患者子宫长径、横径、前后径和宫腔分离值明显短于对照1组,宫腔占位发生率明显低于对照1组,差异均有统计学意义(P<0.05);观察2组患者子宫长径、前后径和宫腔分离值明显短于对照2组,宫腔占位发生率明显低于对照2组,差异均有统计学意义(P<0.05)。用药期间,四组患者均未发现明显不良反应。结论:生化益母汤可促进自然分娩和行剖宫产术患者的产后子宫复旧,能够显著减少恶露量,缩短恶露持续时间,促进子宫恢复,降低宫腔占位发生率。
OBJECTIVE: To probe into the promoting effect of Shenghuayimu decoction on postpartum uterine involution. METHODS: Pregnant women of term delivery admitted into Changzhou Maternal and Child Health Care Hospital Affiliated to Nanjing Medical University in 2017 were selected, 100 cases of spontaneous delivery were divided into observation group 1 and control group 1 via random number table, with 50 cases in each group; 100 cases undergoing cesarean section were divided into observation group 2 and control group 2 via random number table, with 50 cases in each group. Control group 1 and control group 2 were treated with oxytocin, while observation group 1 and observation group 2 were given Shenghuayimu decoction. After 1 course of treatment, differences in the amount of lochia, duration of average lochia, level of uterine involution and incidence of adverse drug reactions between observation group and control group were compared. RESULTS: The average duration of lochia of observation group 1 was significantly shorter than control group 1, the average duration of lochia of observation group 2 was significantly shorter than control group 2, with statistically significant differences(P<0.05). The long diameter, transverse diameter, anteroposterior diameter and separation value of uterine cavity of observation group 1 were significantly shorter than those of control group 1, and the incidence of uterine cavity occupying was significantly lower than control group 1, with statistically significant differences(P<0.05); the long diameter, anteroposterior diameter and separation value of uterine cavity of observation group 2 were significantly shorter than those of control group 2, and the incidence of uterine cavity occupying was significantly lower than control group 2, with statistically significant differences(P<0.05). No significant adverse drug reactions were observed in during treatment. CONCLUSIONS: Shenghuayimu decoction can promote postpartum uterine involution in patients with spontaneous delivery and undergoing cesarean section, which can significantly reduce the amount of lochia, shorten the duration of lochia, promote uterine recovery and reduce the incidence of uterine cavity occupying.
OBJECTIVE: To probe into the promoting effect of Shenghuayimu decoction on postpartum uterine involution. METHODS: Pregnant women of term delivery admitted into Changzhou Maternal and Child Health Care Hospital Affiliated to Nanjing Medical University in 2017 were selected, 100 cases of spontaneous delivery were divided into observation group 1 and control group 1 via random number table, with 50 cases in each group; 100 cases undergoing cesarean section were divided into observation group 2 and control group 2 via random number table, with 50 cases in each group. Control group 1 and control group 2 were treated with oxytocin, while observation group 1 and observation group 2 were given Shenghuayimu decoction. After 1 course of treatment, differences in the amount of lochia, duration of average lochia, level of uterine involution and incidence of adverse drug reactions between observation group and control group were compared. RESULTS: The average duration of lochia of observation group 1 was significantly shorter than control group 1, the average duration of lochia of observation group 2 was significantly shorter than control group 2, with statistically significant differences(P<0.05). The long diameter, transverse diameter, anteroposterior diameter and separation value of uterine cavity of observation group 1 were significantly shorter than those of control group 1, and the incidence of uterine cavity occupying was significantly lower than control group 1, with statistically significant differences(P<0.05); the long diameter, anteroposterior diameter and separation value of uterine cavity of observation group 2 were significantly shorter than those of control group 2, and the incidence of uterine cavity occupying was significantly lower than control group 2, with statistically significant differences(P<0.05). No significant adverse drug reactions were observed in during treatment. CONCLUSIONS: Shenghuayimu decoction can promote postpartum uterine involution in patients with spontaneous delivery and undergoing cesarean section, which can significantly reduce the amount of lochia, shorten the duration of lochia, promote uterine recovery and reduce the incidence of uterine cavity occupying.
引文
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[14] 曹变娜,罗明燕,李芳.生化汤联合甲氨喋呤在早期异位妊娠治疗中的临床研究[J].中国中医药现代远程教育,2018,16(3):108-110.
[15] 王惠,徐晓英,陆月梅,等.口服妈富隆联合生化汤对子宫内膜息肉患者宫腔镜电切术后月经情况及疗效的影响[J].中国妇幼保健,2017,32(18):4391-4393.
[2] 张惠.中医药对产后康复的治疗研究进展[J].中医药学报,2016,44(4):106-109.
[3] 尹小兰,魏绍斌.产后恶露不绝中医药治疗进展[J].辽宁中医药大学学报,2015,17(12):219-222.
[4] 周姣桃,江一样.加味生化汤治疗产后并发症的临床研究[J].中华中医药学刊,2015,33(2):504-506.
[5] 王亚丽,李文林,陈涤平.中医文献中产后养生特色剖析[J].辽宁中医药大学学报,2015,17(9):122-124.
[6] 孙自学,吕小洽,陈翔.《傅青主女科》中归、芎在防治生殖疾病中的应用[J].中医临床研究,2016,8(15):5-7.
[7] 陈光盛,肖红.生化汤源流考[J].内蒙古中医药,2016,35(1):140.
[8] 代良萍.益母草注射液缩宫止血的药效物质基础研究[D].成都:成都中医药大学,2017:29-32.
[9] Liu W,Ma S,Pan W,et al.Combination of motherwort injection and oxytocin for the prevention of postpartum hemorrhage after cesarean section[J].J Matern Fetal Neonatal Med,2016,29(15):2490-2493.
[10] 苗久旺,贾彦敏,于宜平,等.产后恶露不绝治疗的中医方剂组方配伍规律分析[J].中国实验方剂学杂志,2016,22(9):193-197.
[11] 蓝秀青,陈金秀,魏小梨,等.自然分娩与剖宫产对初产妇早期子宫复旧的影响[J].中国当代医药,2017,24(15):179-181.
[12] 曹民治,耿春梅,阿茹娜,等.婴儿喂养方式与产妇体质及产后月经复潮相关性研究[J].中国现代医学杂志,2016,26(24):119-123.
[13] 韩红霞.中药生化汤联合米非司酮及米索前列醇在药物流产中的应用[J].临床合理用药,2015,8(4A):69-70.
[14] 曹变娜,罗明燕,李芳.生化汤联合甲氨喋呤在早期异位妊娠治疗中的临床研究[J].中国中医药现代远程教育,2018,16(3):108-110.
[15] 王惠,徐晓英,陆月梅,等.口服妈富隆联合生化汤对子宫内膜息肉患者宫腔镜电切术后月经情况及疗效的影响[J].中国妇幼保健,2017,32(18):4391-4393.