脉冲振荡法及常规通气法在检测哮喘患儿肺功能的价值研究
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摘要
目的:分析常规通气法及脉冲振荡法在检测哮喘患儿肺功能的临床应用价值。方法:选取103例急性期哮喘患儿,收集患儿两种检测方法的7个肺功能指标:即第1 s用力呼气容积(FEV1)、呼气峰流速(PEF)、最大呼气中段流量(MMEF)和呼吸总阻抗(Zrs)、总气道阻力(R5)、中心气道阻力(R20)以及周边弹性阻力(X5),并对研究数据进行统计分析。结果:FEV1、PEF和MMEF与Zrs、R5、R20存在负相关关系(r=-0.825,r=-0.732,r=-0.846,r=-0.722,r=-0.637,r=-0.797,r=-0.785,r=-0.691,r=-0.847;P<0.05),与X5存在正相关关系(r=0.729,r=0.524,r=0.783;P<0.05),随着哮喘病情严重程度的增加,Zrs、R5及R20增加,而X5减小。结论:肺功能检查能了解哮喘患儿肺功能受损的程度,对儿童哮喘的诊断、病情和治疗效果的判断具有重要价值,而脉冲振荡法和常规通气法的检测可提高对儿童哮喘的临床应用价值。
Objective: To analyze the value of applications of impulse oscillation system and routine pulmonary ventilation method for detecting lung function of children withasthma. Methods: 103 asthmatic children in acute episode were selected, and 7 pulmonary function indexes using two methods mentioned were statistical analyzed, which consisted of FEV1(the forced expiratory volume in one second), PEF(peak expiratory flow), MMEF(maximal mid expiratory flow) and Zrs(respiratory system impedance), R5(total airway resistance), R20(central airway resistance), X5(peripheral elastic resistance). Results: There was negative correlation between FEV1, PEF, MMEF and Zrs, R5, R20(r=-0.825, r=-0.732, r=-0.846, r=-0.722,r=-0.637, r=-0.797, r=-0.785, r=-0.691, r=-0.847; P<0.05). And there was a positive correlation between FEV1, PEF, MMEF and X5(r=0.729, r=0.524, r=0.783; P<0.05). That was, with the degree of asthma increasing, the Zrs, R5 and R20 increased while the x5 decreased. Conclusion: Pulmonary function tests can be used to judge the severity of Pulmonary function in children with asthma, so these tests have enormous value in diagnosis and treatment of childhood asthma. Combined application of impulse oscillation system and conventional pulmonary ventilation method has important clinical values in detecting pulmonary function of Children with asthma.
Objective: To analyze the value of applications of impulse oscillation system and routine pulmonary ventilation method for detecting lung function of children withasthma. Methods: 103 asthmatic children in acute episode were selected, and 7 pulmonary function indexes using two methods mentioned were statistical analyzed, which consisted of FEV1(the forced expiratory volume in one second), PEF(peak expiratory flow), MMEF(maximal mid expiratory flow) and Zrs(respiratory system impedance), R5(total airway resistance), R20(central airway resistance), X5(peripheral elastic resistance). Results: There was negative correlation between FEV1, PEF, MMEF and Zrs, R5, R20(r=-0.825, r=-0.732, r=-0.846, r=-0.722,r=-0.637, r=-0.797, r=-0.785, r=-0.691, r=-0.847; P<0.05). And there was a positive correlation between FEV1, PEF, MMEF and X5(r=0.729, r=0.524, r=0.783; P<0.05). That was, with the degree of asthma increasing, the Zrs, R5 and R20 increased while the x5 decreased. Conclusion: Pulmonary function tests can be used to judge the severity of Pulmonary function in children with asthma, so these tests have enormous value in diagnosis and treatment of childhood asthma. Combined application of impulse oscillation system and conventional pulmonary ventilation method has important clinical values in detecting pulmonary function of Children with asthma.
引文
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[12]魏玉平,江雪红,蒋国华.脉冲振荡肺功能(IOS)评价临床控制的支气管哮喘患者外周气道功能状态[J].临床肺科杂志,2013,18(9):1555-1557.
[13]李博,刘恩梅,任洛,等.儿童哮喘控制测试与肺功能相关性研究[J].中国实用儿科杂志,2012(4):292-295.
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[15]李航,蔡金龙,曲书强.脉冲振荡技术在支气管哮喘治疗效果评价中的临床应用[J].临床肺科杂志,2016,21(1):119-120,176.
[2]向莉,饶小春,焦安夏,等.婴幼儿支气管哮喘和闭塞性细支气管炎患儿肺功能比较[J].临床儿科杂志,2012,30(2):120-123.
[3]林春雨.肺功能检测在小儿哮喘和咳嗽变异性哮喘中的临床应用[J].临床肺科杂志,2014,19(5):923-925.
[4]郁志伟,谢娟娟,钱俊,等.学龄前哮喘儿童体外过敏原筛查与脉冲振荡肺功能检测[J].江苏医药,2012,38(14):1633-1636.
[5]郑劲平.肺功能检查研究进展[J].中国实用内科杂志,2012(8):591-593.
[6]王菲,靳蓉,卢根,等.脉冲振荡肺功能在儿童支气管哮喘中的应用[J].实用儿科临床杂志,2012,27(21):1666-1667.
[7]邹昱馨.哮喘缓解期患儿炎症指标与肺功能的相关性研究[D].大连:大连医科大学,2014.
[8]李雅如.脉冲震荡法监测儿童肺功能的研究进展[J].疾病监测与控制,2014,8(1):27-28.
[9]冯雍,尚云晓.婴幼儿肺功能检测及其在喘息性疾病应用进展[J].中国实用儿科杂志,2014,29(6):424-428.
[10]陈凤.脉冲振荡肺功能治疗支气管哮喘的临床分析[J].临床肺科杂志,2015,20(2):312-314.
[11]高艳,陈海娟,李芳侠.儿童支气管哮喘采用脉冲振荡肺功能的临床意义及应用[J].宁夏医学杂志,2015,37(2):170-172.
[12]魏玉平,江雪红,蒋国华.脉冲振荡肺功能(IOS)评价临床控制的支气管哮喘患者外周气道功能状态[J].临床肺科杂志,2013,18(9):1555-1557.
[13]李博,刘恩梅,任洛,等.儿童哮喘控制测试与肺功能相关性研究[J].中国实用儿科杂志,2012(4):292-295.
[14]蒋雷服.支气管哮喘诊疗中脉冲振荡测定的应用[J].中国实用内科杂志,2013,33(S1):24.
[15]李航,蔡金龙,曲书强.脉冲振荡技术在支气管哮喘治疗效果评价中的临床应用[J].临床肺科杂志,2016,21(1):119-120,176.