动脉粥样硬化中药治疗机制的研究进展
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摘要
动脉粥样硬化的发生发展过程复杂,受到很多因素的影响,严重威胁着人类生命健康。它是心脑血管不良事件发生的重要原因。近些年来,随着人们生活水平的不断提高以及不良生活方式的出现,其发病率逐年升高。越来越多的研究表明,传统中药单体或复方对动脉粥样硬化的治疗有着确切的临床效果。本文将从调节脂质代谢、抗炎抗氧化等几个方面,阐述其抗动脉粥样硬化的作用机制。
The occurrence of atherosclerosis is complicated, and it is affected by many factors, which seriously threatens human health. It is an important cause of adverse cardiovascular and cerebrovascular events.In recent few years, with the continuous improvement of people's living standard and the appearance of unhealthy lifestyles, the incidence rate is increasing year by year. More and more studies show that the traditional Chinese medicine included monomer and compound has a de?nite clinical effect on the treatment of atherosclerosis. In this article, we will expound the mechanism of anti atherosclerosis from the aspects of regulating lipid metabolism,anti-in?ammatory and anti-oxidation.
The occurrence of atherosclerosis is complicated, and it is affected by many factors, which seriously threatens human health. It is an important cause of adverse cardiovascular and cerebrovascular events.In recent few years, with the continuous improvement of people's living standard and the appearance of unhealthy lifestyles, the incidence rate is increasing year by year. More and more studies show that the traditional Chinese medicine included monomer and compound has a de?nite clinical effect on the treatment of atherosclerosis. In this article, we will expound the mechanism of anti atherosclerosis from the aspects of regulating lipid metabolism,anti-in?ammatory and anti-oxidation.
引文
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[18]白洪波,曲悦君,许继德,等.川芎嗪抑制大鼠气道平滑肌细胞增殖和诱导凋亡的研究[J].现代中西医结合杂志,2011(06)
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[20]杨研华,尹莲,朱晓勤,等.牛膝总皂苷的制备及其保护尿酸钠致血管内皮细胞损伤的作用[J].中医药信息,2010(02).
[2]张艳虹,徐凤芹.活血化瘀中药调控细胞自噬抗动脉粥样硬化的研究进展[J].中国中西医结合杂志,2018(08).
[3]郑筱萸.鼓励和引导药学技术人员积极加入执业药师队伍[J].中国药业,2002(08).
[4]白细胞介素28B的基因多态性与丙型肝炎病毒感染转归的关系[J].东南大学学报,2015(10).
[5]Chen Y,Wang W J.[Relationships between insulin resistant and hypertension and traditional Chinese medicine intervention][J].Zhong Xi Yi Jie He Xue Bao,2010,8(12):1114-1118.
[6]Yang Q,Wang S,Xie Y,et al.Effect of salvianolic acid B and paeonol on blood lipid metabolism and hemorrheology in myocardial ischemia rabbits induced by pituitruin[J].Int J Mol Sci,2010,11(10):3696-3704.
[7]蒋世伟,吕晓东.通脉化浊汤对实验性动脉粥样硬化大鼠载脂蛋白的影响[J].辽宁中医药大学学报,2012,14(7):74-76.
[8]张红明,张骁,李晓燕.基质金属蛋白酶的表达对动脉粥样硬化斑块稳定性的影响[J]中华老年心脑血管病杂志,2014,16(10):1109-1111.
[9]王创畅,吴伟,等.清热、活血中药调控TLR4/MyD88/NF-κB信号干预动脉粥样硬化大鼠模型的实验研究[J].中华中医药学刊,2018,36(03).
[10]过晶,陈风,过云峰,等.通心络胶囊对不稳定性心绞痛患者血清高敏C反应蛋白、肿瘤坏死因子-α的影响[J].中国微循环,2009(06).
[11]李世林.牡丹皮镇痛抗炎作用的实验研究[J].中国中医基础医学杂志,2006(01).
[12]Zhang Y,Cao X,Zhu W,et al.Resveratrol enhances autophagic flux and promotes ox LDL degradation in HUVECs via upregulation of SIRT1[J].Oxid Med Cell Longev,2016,2016:7589813.
[13]Zhang BC,Zhang CW,Wang C,et al.Luteolin attenuates foam cell formation and apoptosis in Ox LDL stimulated macrophages by enhancing autophagy[J].Cell Physiol Biochem,2016,39(5):2065-2076.
[14]李麒.基于细胞自噬理论探讨黄芩苷抑制apoE/小鼠动脉粥样硬化发展和促进斑块稳定的分子机制研究[D].济南:山东中医药大学,2014.
[15]张艳虹,徐凤芹.芎芍胶囊对动脉粥样硬化兔主动脉NF-κB及相关炎症因子的影响[J].中华中医药杂志,2014,29(7):2334-2337.
[16]Zhang YH,Zhang Y,Li J,et al.Protective effects of Xiongshao Capsule on anti inflammatory function of high density lipoprotein in atherosclerosis rabbit model[J].Chin J Integr Med,2017,23(5):357、361.
[17]郑红花,李映红,罗德生,等.川芎嗪对血管紧张素Ⅱ诱导的血管平滑肌细胞增殖的抑制作用及机制[J].中国动脉硬化杂志,2006(04).
[18]白洪波,曲悦君,许继德,等.川芎嗪抑制大鼠气道平滑肌细胞增殖和诱导凋亡的研究[J].现代中西医结合杂志,2011(06)
[19]俞静,花宝金,朴炳奎.延胡索乙素对放射所致血管内皮细胞损伤的保护作用[J].中华肿瘤防治杂志,2011(08).
[20]杨研华,尹莲,朱晓勤,等.牛膝总皂苷的制备及其保护尿酸钠致血管内皮细胞损伤的作用[J].中医药信息,2010(02).