中草药中有效成分的提取和分离技术
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摘要
本文总结了近年来中草药中有效成分提取的部分新技术,包括微波提取、组织破碎提取、超高压提取、加压溶剂提取、超声提取、免加热提取、分子印迹技术。主要介绍了这些技术的基本原理、特点、应用情况、存在的问题以及未来发展的方向等,以期为今后中草药提取和分离方面的研究提供一定的参考。
This paper summarized the new technologies of extracting and separating active ingredients of Chinese herbal medicine in recent years,including ultra-high pressure extraction,ultrasonic extraction,microwave extraction,pressurized solvent extraction,tissue fragmentation extraction,heating-free extraction,molecular imprinting technology. The basic principle,characteristics,application progress,existing problems and future development direction of these extraction methods were introduced in order to provide some reference for future research on Extraction and separation of Chinese herbal medicine.
This paper summarized the new technologies of extracting and separating active ingredients of Chinese herbal medicine in recent years,including ultra-high pressure extraction,ultrasonic extraction,microwave extraction,pressurized solvent extraction,tissue fragmentation extraction,heating-free extraction,molecular imprinting technology. The basic principle,characteristics,application progress,existing problems and future development direction of these extraction methods were introduced in order to provide some reference for future research on Extraction and separation of Chinese herbal medicine.
引文
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[2]尹琳琳,陈银玲,刘萍.苋菜红色素的超高压提取工艺及稳定性研究[J].食品科技,2018,43(9):314-320.
[3]张唯,严成,张曦,等.超高压提取玫瑰花色苷及稳定性研究[J].中国调味品,2018,43(8):151-157.
[4]Prasada K N,Hao J,Shi J,et al.Antioxidant and anticancer activities of high pressure-assisted extract of longan (Dimocarpus longan Lour.) fruit pericarp[J].Innovative Food Sci Emerging Technol,2009,10(4):413-419.
[5]刘明言,王帮臣.用于中药提取的新技术进展[J].中草药,2010,41(2):169-175.
[6]刘钧发,冯梦莹,游丽君,等.超声和水提法提取灵芝多糖的结构和抗氧化性的比较研究[J].食品工业科技,2013,34(24):88-92.
[7]张杰,孙源.超声提取蛹虫草多糖及其抗氧化活性分析[J].食品科技,2013,38(5):203-207.
[8]Shirsath S R,Sonawane S H,Gogate P R.Intensification of extraction of natural products using ultrasonic irradiations-A review of current status[J].Chem Eng Process,2012,53:10-23.
[9]Richter B E,Ezzell J L,John B A J,et al.An accelerated solvent extraction system for the rapid preparation of environmental organic compounds in soil[J].Am Lab,1995,27(4):26-28.
[10]Piňeiro Z,Palma M,Barroso C G.Determination of catechins by means of extraction with pressurized liquids[J].J Chromatogr A,2004,1026(1/2):19-23.
[11]Alonso-Salces R M,Barranco A,Corta E,et al.A validated solid-liquid extraction method for the HPLC determination of polyphenols in apple tissues comparison with pressurised liquid extraction[J].Talanta,2005,65(3):654-662.
[12]Cha K H,Lee H J,Koo S Y,et al.Optimization of pressurized liquid extraction of carotenoids and chlorophylls from Chlorella vulgaris[J].J Agric Food Chem,2010,58(2):793-797.
[13]Mottaleb M A,Sarker S D.Accelerated solvent extraction for natural products isolation[J].Methods Mol Biol,2012,864:75-87.
[14]李精云,刘延泽.组织破碎提取法在中药研究中的应用进展[J].中草药,2011,42(10): 2145-2149.
[15]史小莲,刘俊田,李西宽,等.水蛭免加热提取物抗凝血及抗血栓作用[J].中药新药与临床药理,2004,15(2):95-97.
[16]曹广军,张静泽,陈莉,等.免加热工艺大蒜提取物对结肠癌THC8908 细胞活性的影响[J].武警医学院学报,2005,14(3):169-170.
[17]张莉,胡迎庆,高颖,等.辣椒不同工艺提取物的镇痛作用比较[J].药品评价,2006,3(2):109-111.
[18]衣丽娜,尹小英,江一帆,等.分子印迹技术高效分离中药活性成分的应用[J].国际药学研究杂志,2012,39(4):307-310.
[19]豆鹏飞.槲皮素分子印迹聚合物合成及识别研究[J].橡塑技术与装备,2018,44(20):16-23.
[20]张鹏慧,雷佳琦,刘利萍,等.花旗松素分子印迹聚合物合成条件优选及吸附能力的研究[J].中药新药与临床药理,2018,29(5):647-651.
[2]尹琳琳,陈银玲,刘萍.苋菜红色素的超高压提取工艺及稳定性研究[J].食品科技,2018,43(9):314-320.
[3]张唯,严成,张曦,等.超高压提取玫瑰花色苷及稳定性研究[J].中国调味品,2018,43(8):151-157.
[4]Prasada K N,Hao J,Shi J,et al.Antioxidant and anticancer activities of high pressure-assisted extract of longan (Dimocarpus longan Lour.) fruit pericarp[J].Innovative Food Sci Emerging Technol,2009,10(4):413-419.
[5]刘明言,王帮臣.用于中药提取的新技术进展[J].中草药,2010,41(2):169-175.
[6]刘钧发,冯梦莹,游丽君,等.超声和水提法提取灵芝多糖的结构和抗氧化性的比较研究[J].食品工业科技,2013,34(24):88-92.
[7]张杰,孙源.超声提取蛹虫草多糖及其抗氧化活性分析[J].食品科技,2013,38(5):203-207.
[8]Shirsath S R,Sonawane S H,Gogate P R.Intensification of extraction of natural products using ultrasonic irradiations-A review of current status[J].Chem Eng Process,2012,53:10-23.
[9]Richter B E,Ezzell J L,John B A J,et al.An accelerated solvent extraction system for the rapid preparation of environmental organic compounds in soil[J].Am Lab,1995,27(4):26-28.
[10]Piňeiro Z,Palma M,Barroso C G.Determination of catechins by means of extraction with pressurized liquids[J].J Chromatogr A,2004,1026(1/2):19-23.
[11]Alonso-Salces R M,Barranco A,Corta E,et al.A validated solid-liquid extraction method for the HPLC determination of polyphenols in apple tissues comparison with pressurised liquid extraction[J].Talanta,2005,65(3):654-662.
[12]Cha K H,Lee H J,Koo S Y,et al.Optimization of pressurized liquid extraction of carotenoids and chlorophylls from Chlorella vulgaris[J].J Agric Food Chem,2010,58(2):793-797.
[13]Mottaleb M A,Sarker S D.Accelerated solvent extraction for natural products isolation[J].Methods Mol Biol,2012,864:75-87.
[14]李精云,刘延泽.组织破碎提取法在中药研究中的应用进展[J].中草药,2011,42(10): 2145-2149.
[15]史小莲,刘俊田,李西宽,等.水蛭免加热提取物抗凝血及抗血栓作用[J].中药新药与临床药理,2004,15(2):95-97.
[16]曹广军,张静泽,陈莉,等.免加热工艺大蒜提取物对结肠癌THC8908 细胞活性的影响[J].武警医学院学报,2005,14(3):169-170.
[17]张莉,胡迎庆,高颖,等.辣椒不同工艺提取物的镇痛作用比较[J].药品评价,2006,3(2):109-111.
[18]衣丽娜,尹小英,江一帆,等.分子印迹技术高效分离中药活性成分的应用[J].国际药学研究杂志,2012,39(4):307-310.
[19]豆鹏飞.槲皮素分子印迹聚合物合成及识别研究[J].橡塑技术与装备,2018,44(20):16-23.
[20]张鹏慧,雷佳琦,刘利萍,等.花旗松素分子印迹聚合物合成条件优选及吸附能力的研究[J].中药新药与临床药理,2018,29(5):647-651.