食品接触材料及制品中邻苯二甲酸酯类塑化剂的风险管控
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摘要
综述邻苯二甲酸酯类塑化剂的毒理评价和暴露评估,食品和食品接触材料及制品相关法规要求和国内外监测信息,并分析评价塑料、纸张、橡胶、涂层、热塑性弹性体等各类食品接触材料中邻苯二甲酸酯类物质的风险,建议企业警惕迁移风险为高、中的材料和制品,用于接触高油脂、酒精食品或高温、长时间使用的情况,为相关行业有效管控邻苯二甲酸酯类塑化剂风险提供依据。
The toxicological evaluation and exposure assessment of phthalate plasticizers,relevant regulatory requirements and monitoring information at home and abroad for food and food contact materials and products were summarized. The risk of phthalate esters in various food contact materials such as plastics,paper,rubber,coating,thermoplastic elastomers,etc. was analyzed. It was suggested that enterprises should be alert to materials and products with high and medium migration risks,and situations of exposure to high fat,alcoholic food or high temperature and long-term use. It provided basis for effective risk management of phthalate plasticizers in relevant industries.
The toxicological evaluation and exposure assessment of phthalate plasticizers,relevant regulatory requirements and monitoring information at home and abroad for food and food contact materials and products were summarized. The risk of phthalate esters in various food contact materials such as plastics,paper,rubber,coating,thermoplastic elastomers,etc. was analyzed. It was suggested that enterprises should be alert to materials and products with high and medium migration risks,and situations of exposure to high fat,alcoholic food or high temperature and long-term use. It provided basis for effective risk management of phthalate plasticizers in relevant industries.
引文
[1]王晓南,张瑜,王婉华,等.邻苯二甲酸二乙基己酯(DEHP)污染及其毒性研究进展[J].生态毒理学报,2017,12(3):135-150.
[2]MOREAU-GUIGON E,CHEVREUIL M.Human exposure to endocrine disruptors via ambient air:an unknown health risk[J].Arch Mal Prof Environ,2014,75(1):74-81.
[3]白小舰.华南地区典型饮用水源地邻苯二甲酸酯的健康风险评估研究[D].兰州:兰州交通大学,2013.
[4]曹龙,张朝升,陈秋丽,等.邻苯二甲酸酯的环境污染和生态行为及毒理效应研究进展[J].生态毒理学报,2018,13(2):34-46.
[5]BUI T T,GIOVANOULIS G,COUSINS A P,et al.Human exposure,hazard and risk of alternative plasticizers to phthalate esters[J].Sci Total Environ,2016,541:451-467.
[6]WHO.State of the science of endocrine disrupting chemicals-2012[EB/OL].[2018-07-04].http://www.who.int/ceh/publications/endocrine/en/.
[7]GIULIVO M,DE ALDA M L,CAPRI E,et al.Human exposure to endocrine disrupting compounds:their role in reproductive systems,metabolic syndrome and breast cancer.A review[J].Environ Res,2016,151:251-264.
[8]彭鹏,王利,徐新云,等.邻苯二甲酸二(2-乙基己基)酯对St AR基因表达的影响[J].职业与健康,2017,33(24):3340-3343.
[9]马林,马明月.邻苯二甲酸酯类对生殖毒性的影响及其机制的研究进展[J].沈阳医学院学报,2017,19(4):359-363.
[10]国家食品药品监督管理总局.世界卫生组织国际癌症研究机构致癌物清单[EB/OL].[2018-07-01].http://samr.cfda.gov.cn/WS01/CL1991/215896.html.
[11]薛飞龙,沈伊娜.邻苯二甲酸酯对儿童性早熟的影响[J].齐齐哈尔医学院学报,2016,37(24):3074-3075.
[12]王佳,徐希柱,刘英,等.邻苯二甲酸二乙基己基酯暴露与儿童特应性皮炎关系的研究进展[J].环境与职业医学,2016,33(5):517-522.
[13]纪红蕊,杜霞,宋永彬,等.邻苯二甲酸二丁酯的毒性作用及机制[J].沈阳工业大学学报,2017,39(2):230-235.
[14]BORNEHAG C G,CARLSTEDT F,JONSSON B A G,et al.Prenatal phthalate exposures and anogenital distance in Swedish boys[J].Environ Health Persp,2015,123(1):101-107.
[15]KIM S H,CHUN S,JANG J Y,et al.Increased plasma levels of phthalate esters in women with advanced-stage endometriosis:a prospective case-control study[J].Fertil Steril,2011,95(1):357-359.
[16]OLSEN L,LIND L,LIND P M.Associations between circulating levels of bisphenol A and phthalate metabolites and coronary risk in the elderly[J].Ecotoxi Environ Safe,2012,80:179-183.
[17]COKER E S,GUNIER R,HUEN K,et al.DNA methylation and socioeconomic status in a Mexican-American birth cohort[J].Clin Epigenetics,2018,10:61.
[18]World Health Organisation.Diethyl phthalate.Concise international chemical assessment document 52[R].Geneva:WHO,2003.
[19]EFSA.Opinion of the Scientific Panel on food additives,flavourings,processing aids and materials in contact with food(AFC)related to Bis(2-ethylhexyl)phthalate(DEHP)for use in food contact materials[J].EFSA J,2005,3(9):243.
[20]EFSA.Opinion of the Scientific Panel on food additives,flavourings,processing aids and materials in contact with food(AFC)related to Di-isodecylphthalate(DIDP)for use in food contact materials[J].EFSA J,2005,3(9):245.
[21]EFSA.Opinion of the Scientific Panel on food additives,flavourings,processing aids and materials in contact with food(AFC)related to Di-isononylphthalate(DINP)for use in food contact materials[J].EFSA J,2005,3(9):244.
[22]EFSA.Opinion of the Scientific Panel on food additives,flavourings,processing aids and materials in contact with food(AFC)related to di-Butylphthalate(DBP)for use in food contact materials[J].EFSA J,2005,3(9):242.
[23]EFSA.Opinion of the Scientific Panel on food additives,flavourings,processing aids and materials in contact with food(AFC)related to Butylbenzylphthalate(BBP)for use in food contact materials[J].EFSA J,2005,3(9):241.
[24]Market Study:Plasticizers(4th edition)[EB/OL].[2018-07-01].https://www.ceresana.com/en/market-studies/chemicals/plasticizers/.
[25]石志博,姚宁,朱玉,等.邻苯二甲酸酯类增塑剂的正确评价和使用[J].塑料助剂,2009(5):43-49.
[26]FUMEAUX C J F,DIAW C S,PALMERO D,et al.Phthalate exposure in the neonatal intensive care unit[J].Arch Pediatrie,2015,22(2):203-210.
[27]高崇婧,贾璐璐,吴鹏冉,等.中国居民对邻苯二甲酸酯类增塑剂暴露的现状分析[J].暨南大学学报(自然科学与医学版),2017,38(2):93-103,190.
[28]高海涛,李瑞仙,邸倩南,等.我国人群邻苯二甲酸酯类的暴露水平及风险[J].癌变·畸变·突变,2017,29(6):471-475.
[29]卫生部办公厅.卫生部办公厅关于通报食品及食品添加剂邻苯二甲酸酯类物质最大残留量的函[EB/OL].[2018-07-05].http://www.nhfpc.gov.cn/sps/s3594/201211/2b4831f001a740a48086fad152117286.shtml.
[30]香港消费者委员会.测试报告---60款食油大检测!哪款检出塑化剂、污染物或致癌物?[J].选择月刊,2017(489):1-14.
[31]廖燕芝,陈耕,刘璞,等.油茶籽油中邻苯二甲酸酯污染风险来源分析及防范措施研究[J].中国油脂,2018,43(6):90-94.
[32]广州市质量技术监督局.广州质监公布2014年第二批食品抽查结果一批花生油塑化剂超标[EB/OL].[2018-07-05].http://www.cqn.com.cn/news/xfpd/xfjs/spjy/882751.html.
[33]成都市食品药品监督管理局.2016年第七期食品、食用农产品、保健食品监督抽检结果的通报[EB/OL].[2018-07-05].http://www.cdfda.gov.cn/zwgk/zdgzxxgk/jdcjgk/8246.html.
[34]广州市食品药品监督管理局.广州市食品药品监督管理局2017年第19期食品安全监督抽检信息[EB/OL].[2018-07-05].http://www.gz.gov.cn/gzgov/spzlxx/201712/9994b63849354c10a44910ea457 c07 a7.shtml.
[35]广州市食品药品监督管理局.广州市食品药品监督管理局2017年第21期食品安全监督抽检信息[EB/OL].[2018-07-05].http://idc.gzfda.gov.cn/gzfda/shi/201712/cfa92e6ddbe04c5cacd93 e4627 e60292.shtml.
[36]湖北省食品药品监督管理局.2018年6月食品安全监督抽检汇总情况分析[EB/OL].[2018-07-05].http://fda.hubei.gov.cn/zdlm/cjgg/spcjxx/sjgg/38905.htm.
[37]国家卫生和计划生育委员会.食品安全国家标准食品接触材料及制品用添加剂使用标准:GB 9685-2016[S].北京:中国标准出版社,2016.
[38]部授食字第1021350146号令修正.食品器具容器包装卫生标准[S].
[39]European Commission.Commission Regulation(EU)No10/2011 of 14 January 2011 on plastic materials and articles intended to come into contact with food[S].
[40]MFDS.Standards and specifications for food utensils,containers and packages(2017)[S].
[41]European Commission.RASFF Portal[DB/OL].[2018-07-01].https://webgate.ec.europa.eu/rasff-window/portal/index.cfm?event=search Form.
[2]MOREAU-GUIGON E,CHEVREUIL M.Human exposure to endocrine disruptors via ambient air:an unknown health risk[J].Arch Mal Prof Environ,2014,75(1):74-81.
[3]白小舰.华南地区典型饮用水源地邻苯二甲酸酯的健康风险评估研究[D].兰州:兰州交通大学,2013.
[4]曹龙,张朝升,陈秋丽,等.邻苯二甲酸酯的环境污染和生态行为及毒理效应研究进展[J].生态毒理学报,2018,13(2):34-46.
[5]BUI T T,GIOVANOULIS G,COUSINS A P,et al.Human exposure,hazard and risk of alternative plasticizers to phthalate esters[J].Sci Total Environ,2016,541:451-467.
[6]WHO.State of the science of endocrine disrupting chemicals-2012[EB/OL].[2018-07-04].http://www.who.int/ceh/publications/endocrine/en/.
[7]GIULIVO M,DE ALDA M L,CAPRI E,et al.Human exposure to endocrine disrupting compounds:their role in reproductive systems,metabolic syndrome and breast cancer.A review[J].Environ Res,2016,151:251-264.
[8]彭鹏,王利,徐新云,等.邻苯二甲酸二(2-乙基己基)酯对St AR基因表达的影响[J].职业与健康,2017,33(24):3340-3343.
[9]马林,马明月.邻苯二甲酸酯类对生殖毒性的影响及其机制的研究进展[J].沈阳医学院学报,2017,19(4):359-363.
[10]国家食品药品监督管理总局.世界卫生组织国际癌症研究机构致癌物清单[EB/OL].[2018-07-01].http://samr.cfda.gov.cn/WS01/CL1991/215896.html.
[11]薛飞龙,沈伊娜.邻苯二甲酸酯对儿童性早熟的影响[J].齐齐哈尔医学院学报,2016,37(24):3074-3075.
[12]王佳,徐希柱,刘英,等.邻苯二甲酸二乙基己基酯暴露与儿童特应性皮炎关系的研究进展[J].环境与职业医学,2016,33(5):517-522.
[13]纪红蕊,杜霞,宋永彬,等.邻苯二甲酸二丁酯的毒性作用及机制[J].沈阳工业大学学报,2017,39(2):230-235.
[14]BORNEHAG C G,CARLSTEDT F,JONSSON B A G,et al.Prenatal phthalate exposures and anogenital distance in Swedish boys[J].Environ Health Persp,2015,123(1):101-107.
[15]KIM S H,CHUN S,JANG J Y,et al.Increased plasma levels of phthalate esters in women with advanced-stage endometriosis:a prospective case-control study[J].Fertil Steril,2011,95(1):357-359.
[16]OLSEN L,LIND L,LIND P M.Associations between circulating levels of bisphenol A and phthalate metabolites and coronary risk in the elderly[J].Ecotoxi Environ Safe,2012,80:179-183.
[17]COKER E S,GUNIER R,HUEN K,et al.DNA methylation and socioeconomic status in a Mexican-American birth cohort[J].Clin Epigenetics,2018,10:61.
[18]World Health Organisation.Diethyl phthalate.Concise international chemical assessment document 52[R].Geneva:WHO,2003.
[19]EFSA.Opinion of the Scientific Panel on food additives,flavourings,processing aids and materials in contact with food(AFC)related to Bis(2-ethylhexyl)phthalate(DEHP)for use in food contact materials[J].EFSA J,2005,3(9):243.
[20]EFSA.Opinion of the Scientific Panel on food additives,flavourings,processing aids and materials in contact with food(AFC)related to Di-isodecylphthalate(DIDP)for use in food contact materials[J].EFSA J,2005,3(9):245.
[21]EFSA.Opinion of the Scientific Panel on food additives,flavourings,processing aids and materials in contact with food(AFC)related to Di-isononylphthalate(DINP)for use in food contact materials[J].EFSA J,2005,3(9):244.
[22]EFSA.Opinion of the Scientific Panel on food additives,flavourings,processing aids and materials in contact with food(AFC)related to di-Butylphthalate(DBP)for use in food contact materials[J].EFSA J,2005,3(9):242.
[23]EFSA.Opinion of the Scientific Panel on food additives,flavourings,processing aids and materials in contact with food(AFC)related to Butylbenzylphthalate(BBP)for use in food contact materials[J].EFSA J,2005,3(9):241.
[24]Market Study:Plasticizers(4th edition)[EB/OL].[2018-07-01].https://www.ceresana.com/en/market-studies/chemicals/plasticizers/.
[25]石志博,姚宁,朱玉,等.邻苯二甲酸酯类增塑剂的正确评价和使用[J].塑料助剂,2009(5):43-49.
[26]FUMEAUX C J F,DIAW C S,PALMERO D,et al.Phthalate exposure in the neonatal intensive care unit[J].Arch Pediatrie,2015,22(2):203-210.
[27]高崇婧,贾璐璐,吴鹏冉,等.中国居民对邻苯二甲酸酯类增塑剂暴露的现状分析[J].暨南大学学报(自然科学与医学版),2017,38(2):93-103,190.
[28]高海涛,李瑞仙,邸倩南,等.我国人群邻苯二甲酸酯类的暴露水平及风险[J].癌变·畸变·突变,2017,29(6):471-475.
[29]卫生部办公厅.卫生部办公厅关于通报食品及食品添加剂邻苯二甲酸酯类物质最大残留量的函[EB/OL].[2018-07-05].http://www.nhfpc.gov.cn/sps/s3594/201211/2b4831f001a740a48086fad152117286.shtml.
[30]香港消费者委员会.测试报告---60款食油大检测!哪款检出塑化剂、污染物或致癌物?[J].选择月刊,2017(489):1-14.
[31]廖燕芝,陈耕,刘璞,等.油茶籽油中邻苯二甲酸酯污染风险来源分析及防范措施研究[J].中国油脂,2018,43(6):90-94.
[32]广州市质量技术监督局.广州质监公布2014年第二批食品抽查结果一批花生油塑化剂超标[EB/OL].[2018-07-05].http://www.cqn.com.cn/news/xfpd/xfjs/spjy/882751.html.
[33]成都市食品药品监督管理局.2016年第七期食品、食用农产品、保健食品监督抽检结果的通报[EB/OL].[2018-07-05].http://www.cdfda.gov.cn/zwgk/zdgzxxgk/jdcjgk/8246.html.
[34]广州市食品药品监督管理局.广州市食品药品监督管理局2017年第19期食品安全监督抽检信息[EB/OL].[2018-07-05].http://www.gz.gov.cn/gzgov/spzlxx/201712/9994b63849354c10a44910ea457 c07 a7.shtml.
[35]广州市食品药品监督管理局.广州市食品药品监督管理局2017年第21期食品安全监督抽检信息[EB/OL].[2018-07-05].http://idc.gzfda.gov.cn/gzfda/shi/201712/cfa92e6ddbe04c5cacd93 e4627 e60292.shtml.
[36]湖北省食品药品监督管理局.2018年6月食品安全监督抽检汇总情况分析[EB/OL].[2018-07-05].http://fda.hubei.gov.cn/zdlm/cjgg/spcjxx/sjgg/38905.htm.
[37]国家卫生和计划生育委员会.食品安全国家标准食品接触材料及制品用添加剂使用标准:GB 9685-2016[S].北京:中国标准出版社,2016.
[38]部授食字第1021350146号令修正.食品器具容器包装卫生标准[S].
[39]European Commission.Commission Regulation(EU)No10/2011 of 14 January 2011 on plastic materials and articles intended to come into contact with food[S].
[40]MFDS.Standards and specifications for food utensils,containers and packages(2017)[S].
[41]European Commission.RASFF Portal[DB/OL].[2018-07-01].https://webgate.ec.europa.eu/rasff-window/portal/index.cfm?event=search Form.