放射治疗对肺癌患者免疫功能的影响
摘要
肺癌的发生、发展与患者机体的免疫状态密切相关,是肿瘤与机体免疫系统之间相互作用的结果。放射治疗是治疗肺癌的重要手段之一,其对肺癌患者的免疫功能亦具有重要的影响。以往的观点认为,放射治疗具有免疫抑制作用,能够使患者的免疫系统紊乱。但是,放射治疗亦能够激活宿主的天然免疫系统和适应性免疫系统,对肺癌患者的免疫系统具有调节作用。放射治疗联合免疫治疗对肺癌患者的免疫功能具有重要的作用,合理的分割模式和最佳剂量的分布可提高机体的抗肿瘤作用。本文就放射治疗对肺癌患者免疫功能的影响作一简要综述。
引文
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[18]陈卓,于卫江.注射用黄芪多糖对非小细胞肺癌放疗的作用及对机体免疫的影响[J].中国实验方剂学杂志,2013, 19(6):309-313.
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[2] Hill-Kayser CE, Plastaras JP, Tochner Z, et al. TBI duringBM and SCT:review of the past, discussion of the presentand consideration of future directions[J]. Bone MarrowTransplant, 2011, 46(4):475-484.
[3] Lim JY, Brockstedt DG, Lord EM, et al. Radiation therapycombined with Listeria monocytogenes-based cancer vac-cine synergize to enhance tumor control in the B16 melano-ma model[J]. Oncoimmunology, 2014, 3:e29028.
[4] Krieg AM. Therapeutic potential of Toll-like receptor 9 acti-vation[J]. Nat Rev Drug Discov, 2006, 5(6):471-484.
[5] Bourquin C, Schreiber S, Beck S, et al. Immunotherapywith dendritic cells and CpG oligonucleotides can be com-bined with chemotherapy without loss of efficacy in amouse model of colon cancer[J]. Int J Cancer, 2006, 118(11):2790-2795.
[6] Sharma A, Bode B, Wenger RH, et al.γ-Radiation pro-motes immunological recognition of cancer cells through in-creased expression of cancer-testis antigens in vitro and invivo[J]. PLoS One, 2011, 6(11):e28217.
[7] Nesslinger NJ, Sahota RA, Stone B, et al. Standard treat-ments induce antigen-specific immune responses in pros-tate cancer[J]. Clin Cancer Res, 2007, 13(5):1493-1502.
[8] Knudsen S, Schardt A, Buhl T, et al. Enhanced T-cell activa-tion by immature dendritic cells loaded with HSP70-ex-pressing heat-killed melanoma cells[J]. Exp Dermatol,2010, 19(2):108-116.
[9] Levy A, Chargari C, Cheminant M, et al. Radiation therapyand immunotherapy:implications for a combined cancertreatment[J]. Crit Rev Oncol Hematol, 2013, 85(3):278-287.
[10] Blankenstein T, Coulie PG, Gilboa E, et al. The determi-nants of tumour immunogenicity[J]. Nat Rev Cancer,2012, 12(4):307-313.
[11] Castano AP, Mroz P, Hamblin MR. Photodynamic therapyand anti-tumour immunity[J]. Nat Rev Cancer, 2006, 6(7):535-545.
[12] Standish LJ, Torkelson C, Hamill FA, et al. Immune de-fects in breast cancer patients after radiotherapy[J]. J SocIntegr Oncol, 2008, 6(3):110-121.
[13]李月雅,张翠翠,魏熙胤,等.肺癌患者外周血T-淋巴细胞亚群NK细胞的基线数值及其与预后的关系[J].中国肿瘤临床, 2016, 43(5):204-210.
[14] Parker JJ, Jones JC, Strober S, et al. Characterization of di-rect radiation-induced immune function and molecular sig-naling changes in an antigen presenting cell line[J]. ClinImmunol, 2013, 148(1):44-55.
[15] Hatfield P, Merrick A, Harrington K, et al. Radiation-in-duced cell death and dendritic cells:potential for cancerimmunotherapy?[J]. Clin Oncol(R Coll Radiol), 2005, 17(1):1-11.
[16] Garnett CT, Palena C, Chakraborty M, et al. Sublethal irra-diation of human tumor cells modulates phenotype result-ing in enhanced killing by cytotoxic T lymphocytes[J].Cancer Res, 2004, 64(21):7985-7994.
[17] Dewan MZ, Galloway AE, Kawashima N, et al. Fractionat-ed but not single dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody[J]. Clin Cancer Res, 2009, 15(17):5379-5388.
[18]陈卓,于卫江.注射用黄芪多糖对非小细胞肺癌放疗的作用及对机体免疫的影响[J].中国实验方剂学杂志,2013, 19(6):309-313.
[19] Postow MA, Callahan MK, Barker CA, et al. Immunolog-ic correlates of the abscopal effect in a patient with mela-noma[J]. N Engl J Med, 2012, 366(10):925-931.
[20] Golden EB, Formenti SC. Radiation therapy and immuno-therapy:growing pains[J]. Int J Radiat Oncol Biol Phys,2015, 91(2):252-254.
[21] Crittenden M, Kohrt H, Levy R, et al. Current clinical tri-als testing combinations of immunotherapy and radiation[J]. Semin Radiat Oncol, 2015, 25(1):54-64.