血浆IP10水平在PCI术后胸痛患者鉴别诊断中的应用
摘要
目的探究PCI术后患者发生支架内再狭窄及新发冠脉狭窄时血浆趋化因子干扰素-诱导蛋白10(IP10)水平的差异。方法选取2013年7月~2015年1月因典型胸痛入住潍坊市人民医院心内二科且有冠状动脉支架植入史的冠心病患者66例为研究对象,根据冠脉造影结果分为支架内再狭窄组(22),新发冠脉狭窄组(20)及对照组(24例)。记录三组患者的一般临床资料,分别测定各患者血浆IP10μ?浓度比较各组患者的血浆IP10水平,并分析其与支架内再狭窄的相关性。结果支架内再狭窄组患者血浆IP10水平高于新发冠脉狭窄组(P<0.05)及对照组(P<0.05),新发冠脉狭窄组及对照组患者血浆IP10水平差异无统计学意义(P>0.05),逐步Logistic回归分析显示,血浆IP10水平与PCI术后支架内再狭窄呈正相关(OR=1.108,95%CI 1.021~1.202,P=0.014)。结论 PCI术后支架内再狭窄的患者血浆IP10水平高于新发冠脉狭窄的患者,血浆IP10的水平可以作为鉴别PCI术后患者再发胸痛的生化检测指标之一。
Objective To explore the difference of plasma IP10 level between patients with in-stent restenosis and new coronary artery stenosis after PCI. Methods 66 coronary heart disease inpatients who were hospitalized in our center from July 2013 to January 2015 were selected for research, they all complained chest pain and had accepted stent implantation.They were divided into 3groups according to their CAG results: in-stent restenosis group, new coronary artery stenosis and control group. Their clinical data were recorded and the plasma IP10 level of all the patients were tested and analyzed, and the correlation analysis between plasma IP10 level and in-stent restenosis after PCI was also conducted. Result Compared with new coronary artery stenosis and control group, the plasma IP10 level of patients in in-stent restenosis group was higher(P<0.05).(P>0.05); the difference of plasma IP10 level between patients in new coronary artery stenosis and control group had no Statistical significance(P>0.05).Multivariate regression analysis indicated that the plasma IP10 level was positively correlated to the instent restenosis after PCI.Conclusion The plasma IP10 level of patients with in-stent restenosis is higher than that with new coronary artery stenosis after PCI. plasma IP10 level could be one of the indicators used for the differential diagnosis of patients with chest pain after PCI.
Objective To explore the difference of plasma IP10 level between patients with in-stent restenosis and new coronary artery stenosis after PCI. Methods 66 coronary heart disease inpatients who were hospitalized in our center from July 2013 to January 2015 were selected for research, they all complained chest pain and had accepted stent implantation.They were divided into 3groups according to their CAG results: in-stent restenosis group, new coronary artery stenosis and control group. Their clinical data were recorded and the plasma IP10 level of all the patients were tested and analyzed, and the correlation analysis between plasma IP10 level and in-stent restenosis after PCI was also conducted. Result Compared with new coronary artery stenosis and control group, the plasma IP10 level of patients in in-stent restenosis group was higher(P<0.05).(P>0.05); the difference of plasma IP10 level between patients in new coronary artery stenosis and control group had no Statistical significance(P>0.05).Multivariate regression analysis indicated that the plasma IP10 level was positively correlated to the instent restenosis after PCI.Conclusion The plasma IP10 level of patients with in-stent restenosis is higher than that with new coronary artery stenosis after PCI. plasma IP10 level could be one of the indicators used for the differential diagnosis of patients with chest pain after PCI.
引文
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[3]Melter M,Exeni A.Expression of the chemokine receptor CXCR3and its ligand IP-10 during human cardiac allograft rejection.Circulation 2001,104:2558–2564.
[4]Braunersreuther,V.,F.Mach,and S.Steffens,The specific role of chemokines in atherosclerosis.Thromb Haemost,2007.97(5):714-21.
[5]吴兴,张海峰,丁晓凌,等.趋化因子CXCL11及其受体CXCR3在重症急性胰腺炎相关肺损害中的作用[J].世界华人消化杂志,2012,(21):156-157.