摘要
目的:分析万古霉素和替考拉宁致交叉过敏病人的症状、发生率及处理方案,以引起医师及临床药师对罕见药物过敏反应的重视,促进临床合理用药。方法:报道一例重症急性胰腺炎(SAP)病人治疗过程中使用万古霉素及替考拉宁致交叉过敏反应的病例,对该过敏反应的发生机制及流行病学进行讨论,并探讨病人发生此过敏反应时的抗生素替代治疗方案及脱敏治疗。结果:万古霉素及替考拉宁致交叉过敏的案例报道十分罕见,回顾性研究发现,使用万古霉素出现过敏反应的病人,约有10%可能出现对替考拉宁过敏的症状。结论:万古霉素及替考拉宁可诱发交叉过敏反应,一旦出现应立即停药,并换用其他抗生素进行替代治疗,必要时亦可尝试万古霉素脱敏的方法继续进行治疗。
Objective:To investigate symptoms,incidence and treatment of cross-reactivity induced by vancomycin and teicoplanin,so as to arouse the attention of physicians and clinical pharmacists for rare allergic reactions and promote rational use of drugs clinically.Methods:Presented in the paper was a case of cross-reactivity induced by vancomycin and teicoplanin in the treatment of severe acute pancreatitis(SAP).A discussion was made on the mechanism and epidemiology of such allergic reactions,and alternative therapeutic regimens and desensitization protocols were also proposed,when faced with such allergic reactions.Results:Case reports of cross-reactivity induced by vancomycin and teicoplanin were rarely seen.Retrospective study revealed that about 10% of the patients with allergic reactions after application of vancomycin might have allergic reactions to teicoplanin.Conclusion:Vancomycin and teicoplanin might induce cross allergic reactions.Once adverse drug reactions occurr,the drugs applied should be immediately withdrawn and appropriate alternative antibiotics should be used.If necessary,vancomycin desensitization could be a feasible option for continuous treatment.
引文
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