摘要
目的观察通窍鼻炎颗粒对慢性鼻窦炎伴鼻息肉复发的预防作用,并初步探讨其机制。方法将2014年1月~2016年12月就治的慢性鼻窦炎伴鼻息肉患者128例按随机数字表法分为两组,每组64例,两组均实施鼻内镜手术治疗,术后对照组进行常规治疗,观察组加予通窍鼻炎颗粒治疗,2g/次,3次/d,持续治疗2个月,观察两组治疗效果,统计远期复发情况,并检测治疗前、后外周血细胞因子水平变化。结果治疗后,观察组鼻塞、头闷痛评分均低于对照组,Lund-Kennedy内镜黏膜形态评分系统中息肉、水肿、鼻漏、瘢痕、结痂等评分均低于对照组,差异有统计学意义(P<0.05);治疗后,观察组TNF-α、IL-4、IL-9、IL-10、IFN-γ等细胞因子水平低于对照组,差异有统计学意义(P<0.05);治疗12个月后,观察组复发率低于对照组,差异有统计学意义(P<0.05)。结论通窍鼻炎颗粒可缓解慢性鼻窦炎伴鼻息肉患者临床症状,促进鼻腔黏膜修复,可有效预防疾病的远期复发,这可能与通窍鼻炎颗粒对炎症的抑制有关。
Objective To observe the preventive effect of Tongqiao Biyan granule on the recurrence of chronic sinusitis with nasal polyps and to explore its mechanism. Methods One hundred and twenty eight patients with chronic sinusitis with nasal polyps were divided into two groups according to the random number table method from January 2014 to October 2016. Each group was treated with nasal endoscopic surgery. Patients in the observation group were treated with Tongqiao Biyan granule, 2 g/t, 3 t/d, continue treated for 2 months. The treatment effect and the long-term recurrence was observed,and detected blood cytokine levels. Results After treatment, the scores of nasal congestion, headache were lower than those of the control group. The scores of polyp, edema, rhinorrhea,scar and scab were lower in Lund-Kennedy endoscopic mucosal scoring system(P<0.05). After treatment, the levels of TNF-α, IL-4,IL-9, IL-10 and IFN-γ in the observation group were lower than those in the control group, the difference was statistically significant(P<0.05). After 12 months of treatment, the recurrence rate of the observation group was lower than that of the control group, the difference was statistically significant(P<0.05). Conclusion Tongqiao rhinitis granules can relieve the clinical symptoms of chronic sinusitis with nasal polyps and promote nasal mucosal repair, which can effectively prevent the recurrence. This may be related to the inhibition of inflammation by Tongqiao rhinitis granules.
引文
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