1-磷酸鞘氨醇与相关疾病的研究进展
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摘要
1-磷酸鞘氨醇(sphingosine-1-phosphate,S1P)是一种重要的生物活性鞘脂类代谢物,其介导的细胞传导途径(SphK-S1P-S1PRs信号通路)参与各种生理病理过程,调节人体生长发育。现发现5种S1P受体(S1PR1-S1PR5)广泛分布于人体各个组织,其形成的交联信号通路影响着细胞的迁移、粘附、存活和增殖,并干预着肿瘤、糖尿病、心血管疾病等诸多疾病的发生发展过程。因而S1PRs的研究对治疗疾病提供了新的靶点和方向,将其应用于临床,实施个体化治疗方案,成为当今热门的研究课题之一。
引文
1 Tsai HC,Han MH.Sphingosine-1-phosphate(S1P)and S1P signaling pathway:therapeutic targets in autoimmunity and inflammation.Drugs,2016,761067~1079.
2 Blaho VA,Hla T.An update on the biology ofsphingosine 1-phosphate receptors.J Lipid Res,2014,551596~1608.
3 Tang HB,Jiang XJ,Wang C,et al.S1P/S1PR3 signaling mediated proliferation of pericytes via Ras/p ERK pathway and CAY10444 had beneficial effects on spinal cord injury.Biochem Biophys Res Commun,2018,498830~836.
4 Yung BS,Brand CS,Xiang SY,et al.Selective coupling of the S1P3 receptor subtype to S1P-mediated Rho A activation and cardioprotection.J Mol Cell Cardiol,2017,1031~10.
5 Vessey DA,Li L,Imhof I,et al.FTY720 postconditions isolated perfused heart by a mechanism independent of sphingosine kinase 2 and different from S1P or ischemic postconditioning.Med Sci Monit Basic Res,2013,19126~132.
6 Kim GS,Yang L,Zhang G,et,al.Critical role of sphingosine-1-phosphate receptor-2 in the disruption of cerebrovascular integrity in experimental stroke.Nat Commun,2015,67893.
7 Cannavo A,Liccardo D,Komici K,et al.Sphingosine kinases and sphingosine 1-phosphate receptors:signaling and actions in the cardiovascular system.Front Pharmacol,2017,8556.
8 Blanchard O,Stepanovska B,Starck M,et al.Downregulation of the S1P transporter spinster homology protein 2(Spns2)exerts an anti-fibrotic and anti-inflammatory effect in human renal proximal tubular epithelial cells.Int J Mol Sci,2018,191498~1516.
9 Kitada Y,Kajita K,Taguchi K,et al.Blockade of sphingosine 1-phosphate receptor 2 signaling attenuates high-fat dietinduced adipocyte hypertrophy and systemic glucose intolerance in mice.Endocrinology,2016,1571839~1851.
10 Bekpinar S,Yenidunya G,Gurdol F.The effect of nephropathy on plasma sphingosine 1-phosphate concentrations in patients with type 2 diabetes.Clin Biochem,2015,481264~1267.
11 Hatoum D,Haddadi N,Lin Y,et al.Mammalian sphingosine kinase(Sph K)isoenzymes and isoform expression:challenges for Sph K as an oncotarget.Oncotarget,2017,836898~36929.
12 Wang YC,Tsai CF,Chuang HL.Benzyl butyl phthalate promotes breast cancer stem cell expansion via SPHK1/S1P/S1PR3 signaling.Oncontarget,2016,729563~29576.
13 Yang J,Yang C,Zhang S,et al.ABC294640,a sphingosine kinase 2 inhibitor,enhances the antitumor effects of TRAIL in non-small cell lung cancer.Cancer Biol Ther,2015,161194~1204.
14 Mohammed S,Harikumar KB.Sphingosine 1-phosphate:a novel target for lung disorders.Front Immunol,2017,8296.
15 Ebenezer DL,Fu P,Natarajan V.Targeting sphingosine-1-phosphate signaling in lung diseases.Pharmacol Ther,2016,168143.
16 Huang LS,Natarajan V.Sphingolipids in pulmonary fibrosis.Adv Biol Regul,2015,5755~63.
17 Ebenezer DL,Fu P,Suryadevara V,et al.Epigenetic regulation of pro-inflammatory cytokine secretion by sphingosine 1-phosphate(S1P)in acute lung injury:Role of S1P Lyase.Adv Biol Regul,2017,63156~166.
18 Wollny T,Wtek M,Durna B,et al.Sphingosine-1-phosphate metabolism and its role in the development of inflammatory bowel disease.Int J Mol Sci,2017,18741~754.
19 White JR,Phillips F,Monaghan T,et al.Review article:novel oral-targeted therapies in inflammatory bowel disease.Aliment Pharmacol Ther,2018,471610~1622.
20 DegagnéE,Saba JD.Sphingosine-1-phosphate signaling as an emerging target in inflammatory bowel disease and colitis-associated cancer.Clin Exp Gastroenterol,2014,7205~214.
21 Saeedi BJ,Kao DJ,Kitzenberg DA,et al.HIF-dependent regulation of claudin-1 is central to intestinal epithelial tight junction integrity.Mol Biol Cell,2015,262252~2262.
22 Song J,Dagan A,Yakhtin Z,et al.The novel sphingosine-1-phosphate receptors antagonist AD2900 affects lymphocyte activation and inhibits T-cell entry into the lymph nodes.Oncotarget,2017,853563~53580.
23 Tanaka K,Hashizume M,Mihara M,et al.Anti-interleukin-6 receptor antibody prevents systemic bone mass loss via reducing the number of osteoclast precursors in bone marrow in a collagen-induced arthritis model.Clin Exp Immunol,2014,175172~180.
24 Halmer R,Walter S,Fabender K.Sphingolipids:important players in multiple sclerosis.Cell Physiol Biochem,2014,34111~118.
25 Lan T,Li C,Yang G,et al.Sphingosine kinase 1 promotes liver fibrosis by preventing miR-19b-3p-mediated inhibition of CCR2.Hepatology,2018,681070~1086.
26 Xiu L,Chang N,Yang L,et al.Intracellular sphingosine 1-phosphate contributes to collagen expressionof hepatic myofibroblasts in human liver fibrosis independent of its receptors.Am J Pathol,2015,185387~398.
27 Wang Y,Aoki H,Yang J,et al.The role of S1PR2 in bile acid-induced cholangiocyte proliferation and cholestasis-induced liver injury in mice.Hepatology,2017,652005~2018.
28 Orr Gandy KA,Obeid LM.Targeting the sphingosine kinase/sphingosine 1-phosphate pathway in disease:review of sphingosine kinase inhibitors.Biochim Biophys Acta,2013,1831157~166.
29 Subei AM,Cohen JA.Sphingosine 1-phosphate receptor modulators in multiple sclerosis.CNS Drugs,2015,29565~575.
2 Blaho VA,Hla T.An update on the biology ofsphingosine 1-phosphate receptors.J Lipid Res,2014,551596~1608.
3 Tang HB,Jiang XJ,Wang C,et al.S1P/S1PR3 signaling mediated proliferation of pericytes via Ras/p ERK pathway and CAY10444 had beneficial effects on spinal cord injury.Biochem Biophys Res Commun,2018,498830~836.
4 Yung BS,Brand CS,Xiang SY,et al.Selective coupling of the S1P3 receptor subtype to S1P-mediated Rho A activation and cardioprotection.J Mol Cell Cardiol,2017,1031~10.
5 Vessey DA,Li L,Imhof I,et al.FTY720 postconditions isolated perfused heart by a mechanism independent of sphingosine kinase 2 and different from S1P or ischemic postconditioning.Med Sci Monit Basic Res,2013,19126~132.
6 Kim GS,Yang L,Zhang G,et,al.Critical role of sphingosine-1-phosphate receptor-2 in the disruption of cerebrovascular integrity in experimental stroke.Nat Commun,2015,67893.
7 Cannavo A,Liccardo D,Komici K,et al.Sphingosine kinases and sphingosine 1-phosphate receptors:signaling and actions in the cardiovascular system.Front Pharmacol,2017,8556.
8 Blanchard O,Stepanovska B,Starck M,et al.Downregulation of the S1P transporter spinster homology protein 2(Spns2)exerts an anti-fibrotic and anti-inflammatory effect in human renal proximal tubular epithelial cells.Int J Mol Sci,2018,191498~1516.
9 Kitada Y,Kajita K,Taguchi K,et al.Blockade of sphingosine 1-phosphate receptor 2 signaling attenuates high-fat dietinduced adipocyte hypertrophy and systemic glucose intolerance in mice.Endocrinology,2016,1571839~1851.
10 Bekpinar S,Yenidunya G,Gurdol F.The effect of nephropathy on plasma sphingosine 1-phosphate concentrations in patients with type 2 diabetes.Clin Biochem,2015,481264~1267.
11 Hatoum D,Haddadi N,Lin Y,et al.Mammalian sphingosine kinase(Sph K)isoenzymes and isoform expression:challenges for Sph K as an oncotarget.Oncotarget,2017,836898~36929.
12 Wang YC,Tsai CF,Chuang HL.Benzyl butyl phthalate promotes breast cancer stem cell expansion via SPHK1/S1P/S1PR3 signaling.Oncontarget,2016,729563~29576.
13 Yang J,Yang C,Zhang S,et al.ABC294640,a sphingosine kinase 2 inhibitor,enhances the antitumor effects of TRAIL in non-small cell lung cancer.Cancer Biol Ther,2015,161194~1204.
14 Mohammed S,Harikumar KB.Sphingosine 1-phosphate:a novel target for lung disorders.Front Immunol,2017,8296.
15 Ebenezer DL,Fu P,Natarajan V.Targeting sphingosine-1-phosphate signaling in lung diseases.Pharmacol Ther,2016,168143.
16 Huang LS,Natarajan V.Sphingolipids in pulmonary fibrosis.Adv Biol Regul,2015,5755~63.
17 Ebenezer DL,Fu P,Suryadevara V,et al.Epigenetic regulation of pro-inflammatory cytokine secretion by sphingosine 1-phosphate(S1P)in acute lung injury:Role of S1P Lyase.Adv Biol Regul,2017,63156~166.
18 Wollny T,Wtek M,Durna B,et al.Sphingosine-1-phosphate metabolism and its role in the development of inflammatory bowel disease.Int J Mol Sci,2017,18741~754.
19 White JR,Phillips F,Monaghan T,et al.Review article:novel oral-targeted therapies in inflammatory bowel disease.Aliment Pharmacol Ther,2018,471610~1622.
20 DegagnéE,Saba JD.Sphingosine-1-phosphate signaling as an emerging target in inflammatory bowel disease and colitis-associated cancer.Clin Exp Gastroenterol,2014,7205~214.
21 Saeedi BJ,Kao DJ,Kitzenberg DA,et al.HIF-dependent regulation of claudin-1 is central to intestinal epithelial tight junction integrity.Mol Biol Cell,2015,262252~2262.
22 Song J,Dagan A,Yakhtin Z,et al.The novel sphingosine-1-phosphate receptors antagonist AD2900 affects lymphocyte activation and inhibits T-cell entry into the lymph nodes.Oncotarget,2017,853563~53580.
23 Tanaka K,Hashizume M,Mihara M,et al.Anti-interleukin-6 receptor antibody prevents systemic bone mass loss via reducing the number of osteoclast precursors in bone marrow in a collagen-induced arthritis model.Clin Exp Immunol,2014,175172~180.
24 Halmer R,Walter S,Fabender K.Sphingolipids:important players in multiple sclerosis.Cell Physiol Biochem,2014,34111~118.
25 Lan T,Li C,Yang G,et al.Sphingosine kinase 1 promotes liver fibrosis by preventing miR-19b-3p-mediated inhibition of CCR2.Hepatology,2018,681070~1086.
26 Xiu L,Chang N,Yang L,et al.Intracellular sphingosine 1-phosphate contributes to collagen expressionof hepatic myofibroblasts in human liver fibrosis independent of its receptors.Am J Pathol,2015,185387~398.
27 Wang Y,Aoki H,Yang J,et al.The role of S1PR2 in bile acid-induced cholangiocyte proliferation and cholestasis-induced liver injury in mice.Hepatology,2017,652005~2018.
28 Orr Gandy KA,Obeid LM.Targeting the sphingosine kinase/sphingosine 1-phosphate pathway in disease:review of sphingosine kinase inhibitors.Biochim Biophys Acta,2013,1831157~166.
29 Subei AM,Cohen JA.Sphingosine 1-phosphate receptor modulators in multiple sclerosis.CNS Drugs,2015,29565~575.