LIBS光谱技术鉴别原料药或辅料中的金属元素
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摘要
目的:建立简便、快速鉴别原料药或药用辅料中金属元素的激光诱导击穿光谱法(LIBS)。方法:以择几种含钠、钾、镁、钙、锌元素的原料药或药用辅料为模型,采用LIBS采集样品的原子光谱,基于原子光谱理论和NIST数据库,对166～800 nm波段范围内LIBS谱线进行辨识,鉴别样品中的金属元素。结果:获得的LIBS光谱中的特征谱线与样品中的金属元素一一对应。结论:LIBS光谱法是鉴别药物或药用辅料中金属元素的快速、准确、可靠的方法。
Objective:To establish a simple and rapid method to identify metal elements in active pharmaceutical ingredients(APIs)or pharmaceutical excipients by laser-induced breakdown spectroscopy(LIBS). Methods:Select several APIs or pharmaceutical excipients containing Na,K,Mg,Ca,Zn as models,and collect their LIBS spectra in 166-800 nm wavelength range.Based on the theoretical knowledge of atomic spectroscopy and the NIST database,spectra analysis,the metal elements existing in the samples were identified. Results:The characteristic spectral lines obtained from the LIBS spectra correspond to the metal elements in the samples. Conclusion:LIBS technique can be used as a rapid,accurate and reliable method for identification of metal elements in APIs and excipients.
Objective:To establish a simple and rapid method to identify metal elements in active pharmaceutical ingredients(APIs)or pharmaceutical excipients by laser-induced breakdown spectroscopy(LIBS). Methods:Select several APIs or pharmaceutical excipients containing Na,K,Mg,Ca,Zn as models,and collect their LIBS spectra in 166-800 nm wavelength range.Based on the theoretical knowledge of atomic spectroscopy and the NIST database,spectra analysis,the metal elements existing in the samples were identified. Results:The characteristic spectral lines obtained from the LIBS spectra correspond to the metal elements in the samples. Conclusion:LIBS technique can be used as a rapid,accurate and reliable method for identification of metal elements in APIs and excipients.
引文
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[3]DUBEYA,KEYVAN G,HSIAR,et al.Analysis of pharmaceutical tablet coating uniformity by LIBS[J].J Pharm Innov,2011,6(2):77
[4]MYAKALWARAK,SREEDHARS,BARMANI,et al.Laserinduced breakdown spectroscopy-based investigation and classification of pharmaceutical tablets using multivariate chemometric analysis[J].Talanta,2011,87:53
[5]温冠宏.基于激光诱导击穿光谱技术的中药材天麻成分定性分析[J].科海故事博览·科技探索,2013(5):352WEN GH.Qualitative analysis of the active constituents in gastrodiaelata by using laser-induced breakdown spectroscopy)[J].Kehai Gushi Bolan:keji Tansuo,2013(5):352
[6]AKPOVO CA,JORGE AM,LEWIS DE,et al.Regional discrimination of oysters using laser-induced breakdown spectroscopy[J].Anal Methods,2013,5(16):3956
[7]吴金泉,林兆祥,刘林美,等.藏药七十味珍珠丸的激光诱导击穿光谱检测[J].中南民族大学学报(自然科学版),2009,28(2):53WU JQ,LIN ZX,LIU Lm,et al.Determination Tibetan medicine of the 70 Pearl Flavor Pill by laser-induced breakdown spectroscopy[J].J South-Cent Univ Nation,2009,28(2):53
[8]刘晓娜,张乔,史新元,等.基于LIBS技术的树脂类药材快速元素分析及判别方法研究[J].中华中医药杂志,2015,30(5):1610LIU XN,ZHANG Q,SHI XY,et al.Rapid elemental analysis and classification of resin herbs based on LIBS technique[J].China JTradit Chin Med Pharm,2015,30(5):1610
[9]刘晓娜,史新元,贾帅芸,等,基于LIBS技术对4种珍宝藏药快速多元素分析[J].中国中药杂志,2015,40(11):2239LIU XN,SHI XY,JIA SY,et al.Rapid multi-elemental analysis on four precious Tibetan medicines based on LIBS technique[J].China J Chin Mater Med,2015,40(11):2239
[10]董晨钟,杨峰,苏茂根.中药材微量元素成分的LIBS检测[J].西北师范大学学报(自然科学版),2015,51(1):44DONG CZ,YANG F,SU MG.Measurement on trace element composition of Chinese medicinal materials by laser-induced breakdown spectroscopy[J].J Northwest Norm Univ(Nat Sci),2015,51(1):44
[11]李占锋,王芮雯,邓琥,等.黄连、附片和茯苓内铜元素激光诱导击穿光谱分析[J].发光学报,2016,37(1):100LI ZF,WANG RW,DENG H,et al.Laser-induced breakdown spectroscopy of Cu in Coptischinensis aconite root and poriacocos[J].Chin J Luminesc,2016,37(1):100
[12]李占锋,王芮雯,邓琥,等.黄连中Pb的激光诱导击穿光谱测量分析[J].红外与激光工程,2016,45(10):1006003-1LI ZF,WANG RW,DENG H,et al.Laser induced breakdown spectroscopy of Pb in Coptischinensis[J].Infr Laser Engin,2016,45(10):1006003-1
[13]张大成,马新文,赵冬梅,等.药用胶囊中铬元素的LIBS快速检测[J].药物分析杂志,2013,33(12):2070ZHANG DC,MA XW,ZHAO DM,et al.Rapid detection of chromium in medicinal capsules by LIBS technology[J].Chin JPharm Anal,2013,33(12):2070
[14]谢承利,陆继东,姚顺春,等.激光诱导击穿光谱物质辨识与定量分析[J].激光与光电子学进展,2009,46(11):65XIE CL,LU JD,YAO SC,et al.Quantitative analysis and material identification by laser induced breakdown spectroscopy[J].Laser Optoelectr Prog,2009,46(11):65
[15]NIST Atomic Spectra Database[EB/OL].(2017-11)[2018-4-14],https://www.nist.gov/pml/atomic-spectra-database
[16]Perkin-Elmer Corporation.Winlab 32TM Optima 3100-3300 TMWavelength Tables[R].PE,1999
[17]陈新坤.原子发射光谱分析原理[M].天津:天津科学技术出版社,1991:25CHEN XK.Theory of Atomic Emission Spectral Analysis[M].Tianjin:Tianjin Science and Technology Press,1991:25
[18]柯以侃,董慧茹.光谱分析[M]//周同惠.分析化学手册,第二版,北京:化学工业出版社,1998:84KE YK,DONG HR.Spectral Analysis[M]//ZHOU TH.Manual of Analytical Chemistry,2 nd Ed.Beijing:Chemical Industry Press,1998:84