黄芩有效成分治疗冠心病的实验研究进展
摘要
通过查阅近年来国内外黄芩药理作用方面的相关文献报道,对黄芩有效成分治疗冠心病的作用机制进行总结和归纳,认为黄芩有效成分具有降血脂及抗动脉粥样硬化、抑制心肌缺血再灌注损伤、抗炎和抗氧化、抑制心肌纤维化和血管平滑肌细胞增殖、抗凝血和抗血栓形成及扩张血管和降血压等方面的药理作用。
引文
[1]王敏.黄芩苷对小鼠动脉粥样硬化及脂联素表达水平的影响[D].济南:山东大学,2012.
[2]于昕,刘向群,陈焕芹,等.黄芩苷对动脉粥样硬化大鼠凝血酶激活纤溶抑制物水平及血脂、凝血纤溶指标的影响[J].中国老年学杂志,2010,30(22):3299-3301.
[3]周晓霞,尤翠兰,苏佩清,等.黄芩茎叶总黄酮对高脂血症大鼠脂代谢的影响[J].中药新药与临床药理,2009,20(2):99.
[4]周晓慧,任立群,高玄,等.黄芩茎叶总黄酮对高脂血症兔主动脉VCAM-1、ICAM-1表达的影响[J].中国老年学杂志,2010,30(11):3,124.
[5]蔺兆林.黄芩茎叶总黄酮调血脂作用研究[J].内蒙古中医药,2014,33(8):45.
[6]彭蕾,顾振纶,薛仁宇,等.黄芩素对大鼠高脂血症性脂肪肝的防治作用研究[J].中成药,2011,33(3):414-418.
[7]Cui G,Luk SC,Li RA,et al.Cytoprotection of baicalein against oxidative stress-induced cardiomyocytes injury through the Nrf2/Keap1 pathway[J].Journal of Cardiovascular Pharmacology,2015,65(1):39.
[8]Lee YM,Cheng PY,Chen SY,et al.Wogonin suppresses arrhythmias,inflammatory responses,and apoptosis induced by myocardial ischemia/reperfusion in rats[J].Journal of Cardiovascular Pharmacology,2011,58(2):133-142.
[9]于晓敏.黄芩茎叶总黄酮对大鼠心肌缺血再灌注JAK/STAT通路的干预作用[D].承德:承德医学院,2012.
[10]Zhou XH,Gong MY,Yang HM.Effects of scutellaria stemleaf total flavonoids on cardiocyte apoptosis induced by hypoxia/reoxygenation[J].Chinese Journal of Integrated Traditional&Western Medicine,2011,31(6):803.
[11]Lee YM,Cheng PY,Chen SY,et al.Wogonin suppresses arrhythmias,inflammatory responses,and apoptosis induced by myocardial ischemia/reperfusion in rats[J].J Cardiovasc Pharmacol,2011,58(2):133-142.
[12]Khan S,Zhang D,Zhang Y,et al.Wogonin attenuates diabetic cardiomyopathy through its anti-inflammatory and anti-oxidative properties[J].Molecular&Cellular Endocrinology,2016,428(C):101-108.
[13]Chen HM,Hsu JH,Liou SF,et al.Baicalein,an active component of Scutellaria baicalensis Georgi,prevents lysophosphatidylcholine-induced cardiac injury by reducing reactive oxygen species production,calcium overload and apoptosis via MAPK pathways[J].Bmc Complementary&Alternative Medicine,2014,14(1):233.
[14]Kumar M,Kasala ER,Bodduluru LN,et al.Baicalein protects isoproterenol induced myocardial ischemic injury in male Wistar rats by mitigating oxidative stress and inflammation[J].Inflamm Res,2016,65(8):613-622.
[15]Tan S,Zhou S,Luo Y.Baicalein pretreatment confers cardioprotection against acute myocardial infarction by activating the endothelial nitric oxide synthase signaling pathway and inhibiting oxidative stress[J].Mol Med Rep,2014,9(6):2429-2434.
[16]Chan E,Liu XX,Guo DJ,et al.Extract of Scutellaria baicalensis Georgi root exerts protection against myocardial ischemia-reperfusion injury in rats[J].Am J Chin Med,2011,39(4):693-704.
[17]Kong EK,Yu S,Sanderson JE,et al.A novel anti-fibrotic agent,baicalein,for the treatment of myocardial fibrosis in spontaneously hypertensive rats[J].Eur J Pharmacol,2011,658(2-3):175-181.
[18]Zhao F,Fu L,Yang W,et al.Cardioprotective ef fects of baicalein on heart failure via modulation of Ca(2+)handling proteins in vivo and in vitro[J].Life Sci,2016,15(145):213-223.
[19]Zong J,Zhang DP,Zhou H,et al.Baicalein protects against cardiac hypertrophy through blocking MEK-ERK1/2signaling[J].J Cell Biochem,2013,114(5):1058-1065.
[20]呼海娟.黄芩苷抑制内皮损伤诱导的血管新生内膜形成及其机制[D].石家庄:河北医科大学,2009.
[21]罗德生,郑红花,罗丽丹,等.黄芩煎剂对四氯化碳致大鼠急性肝损伤的保护作用[J].陕西中医,2004,25(2):184.
[22]马屏南,于水永.简述黄芩的药理作用与临床应用[J].中国药物经济学,2013,8(S2):282-287.
[23]刘纯,宋成文.黄芩苷对血管内皮细胞作用机制的研究进展[J].华南国防医学杂志,2015,29(7):569-572.
[24]黑爱连,孙倾三.黄芩苷对大鼠主动脉条收缩的影响[J].首都医科大学学报,1997,18(2):114.
[25]卞筱泓,张映桥,许激扬,等.黄芩苷对离体大鼠胸主动脉的舒张作用及机制[J].药物生物技术,2013,20(2):146-148.
[26]Chen ZY,Su YL,Lau CW,et al.Endothelium-dependent contraction and direct relaxation induced by baicalin in rat mesenteric artery[J].Eur J Pharmacol,1999,374(1):41.
[27]辛文妤,宋俊科,何国荣,等.黄芩素和黄芩苷的药理作用及机制研究进展[J].中国新药杂志,2013,22(6):647.
[28]益文杰,张丽敏,佟继铭.黄芩茎叶总黄酮对正常及肾动脉狭窄模型大鼠血压的影响[J].中国临床康复,2006,10(31):179.
[29]Enoch Chan,Xing-Xian Liu,De-Jian Guo,et al.Extract of scutellaria baicalensis georgi root exerts protection against myocardial ischemia-reperfusion injury in rats[J].American Journal of Chinese Medicine,2011,39(4):693-704.
[2]于昕,刘向群,陈焕芹,等.黄芩苷对动脉粥样硬化大鼠凝血酶激活纤溶抑制物水平及血脂、凝血纤溶指标的影响[J].中国老年学杂志,2010,30(22):3299-3301.
[3]周晓霞,尤翠兰,苏佩清,等.黄芩茎叶总黄酮对高脂血症大鼠脂代谢的影响[J].中药新药与临床药理,2009,20(2):99.
[4]周晓慧,任立群,高玄,等.黄芩茎叶总黄酮对高脂血症兔主动脉VCAM-1、ICAM-1表达的影响[J].中国老年学杂志,2010,30(11):3,124.
[5]蔺兆林.黄芩茎叶总黄酮调血脂作用研究[J].内蒙古中医药,2014,33(8):45.
[6]彭蕾,顾振纶,薛仁宇,等.黄芩素对大鼠高脂血症性脂肪肝的防治作用研究[J].中成药,2011,33(3):414-418.
[7]Cui G,Luk SC,Li RA,et al.Cytoprotection of baicalein against oxidative stress-induced cardiomyocytes injury through the Nrf2/Keap1 pathway[J].Journal of Cardiovascular Pharmacology,2015,65(1):39.
[8]Lee YM,Cheng PY,Chen SY,et al.Wogonin suppresses arrhythmias,inflammatory responses,and apoptosis induced by myocardial ischemia/reperfusion in rats[J].Journal of Cardiovascular Pharmacology,2011,58(2):133-142.
[9]于晓敏.黄芩茎叶总黄酮对大鼠心肌缺血再灌注JAK/STAT通路的干预作用[D].承德:承德医学院,2012.
[10]Zhou XH,Gong MY,Yang HM.Effects of scutellaria stemleaf total flavonoids on cardiocyte apoptosis induced by hypoxia/reoxygenation[J].Chinese Journal of Integrated Traditional&Western Medicine,2011,31(6):803.
[11]Lee YM,Cheng PY,Chen SY,et al.Wogonin suppresses arrhythmias,inflammatory responses,and apoptosis induced by myocardial ischemia/reperfusion in rats[J].J Cardiovasc Pharmacol,2011,58(2):133-142.
[12]Khan S,Zhang D,Zhang Y,et al.Wogonin attenuates diabetic cardiomyopathy through its anti-inflammatory and anti-oxidative properties[J].Molecular&Cellular Endocrinology,2016,428(C):101-108.
[13]Chen HM,Hsu JH,Liou SF,et al.Baicalein,an active component of Scutellaria baicalensis Georgi,prevents lysophosphatidylcholine-induced cardiac injury by reducing reactive oxygen species production,calcium overload and apoptosis via MAPK pathways[J].Bmc Complementary&Alternative Medicine,2014,14(1):233.
[14]Kumar M,Kasala ER,Bodduluru LN,et al.Baicalein protects isoproterenol induced myocardial ischemic injury in male Wistar rats by mitigating oxidative stress and inflammation[J].Inflamm Res,2016,65(8):613-622.
[15]Tan S,Zhou S,Luo Y.Baicalein pretreatment confers cardioprotection against acute myocardial infarction by activating the endothelial nitric oxide synthase signaling pathway and inhibiting oxidative stress[J].Mol Med Rep,2014,9(6):2429-2434.
[16]Chan E,Liu XX,Guo DJ,et al.Extract of Scutellaria baicalensis Georgi root exerts protection against myocardial ischemia-reperfusion injury in rats[J].Am J Chin Med,2011,39(4):693-704.
[17]Kong EK,Yu S,Sanderson JE,et al.A novel anti-fibrotic agent,baicalein,for the treatment of myocardial fibrosis in spontaneously hypertensive rats[J].Eur J Pharmacol,2011,658(2-3):175-181.
[18]Zhao F,Fu L,Yang W,et al.Cardioprotective ef fects of baicalein on heart failure via modulation of Ca(2+)handling proteins in vivo and in vitro[J].Life Sci,2016,15(145):213-223.
[19]Zong J,Zhang DP,Zhou H,et al.Baicalein protects against cardiac hypertrophy through blocking MEK-ERK1/2signaling[J].J Cell Biochem,2013,114(5):1058-1065.
[20]呼海娟.黄芩苷抑制内皮损伤诱导的血管新生内膜形成及其机制[D].石家庄:河北医科大学,2009.
[21]罗德生,郑红花,罗丽丹,等.黄芩煎剂对四氯化碳致大鼠急性肝损伤的保护作用[J].陕西中医,2004,25(2):184.
[22]马屏南,于水永.简述黄芩的药理作用与临床应用[J].中国药物经济学,2013,8(S2):282-287.
[23]刘纯,宋成文.黄芩苷对血管内皮细胞作用机制的研究进展[J].华南国防医学杂志,2015,29(7):569-572.
[24]黑爱连,孙倾三.黄芩苷对大鼠主动脉条收缩的影响[J].首都医科大学学报,1997,18(2):114.
[25]卞筱泓,张映桥,许激扬,等.黄芩苷对离体大鼠胸主动脉的舒张作用及机制[J].药物生物技术,2013,20(2):146-148.
[26]Chen ZY,Su YL,Lau CW,et al.Endothelium-dependent contraction and direct relaxation induced by baicalin in rat mesenteric artery[J].Eur J Pharmacol,1999,374(1):41.
[27]辛文妤,宋俊科,何国荣,等.黄芩素和黄芩苷的药理作用及机制研究进展[J].中国新药杂志,2013,22(6):647.
[28]益文杰,张丽敏,佟继铭.黄芩茎叶总黄酮对正常及肾动脉狭窄模型大鼠血压的影响[J].中国临床康复,2006,10(31):179.
[29]Enoch Chan,Xing-Xian Liu,De-Jian Guo,et al.Extract of scutellaria baicalensis georgi root exerts protection against myocardial ischemia-reperfusion injury in rats[J].American Journal of Chinese Medicine,2011,39(4):693-704.