人参皂苷的抗血小板作用
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摘要
人参皂苷(Ginsenoside,GS)具有多种心血管药理作用,也显示出抗血小板作用。目前研究显示,人参总皂苷、GS-Re、GS-Rg1、GS-Rk1、GS-Rg3及GS-Rg3衍生物GS-Rp1均具有抗血小板作用。GS能够提高抗血小板药物治疗效果,可能是现代血栓栓塞性疾病药物治疗的重要补充。应用miRNA等新技术、分子模块等新观点等可以指导GS的抗血小板研究。
Multifunctions of ginsenoside(GS),including antiplatelet effect,has been found in protecting cardiovascular system. Current evidence supports the antiplatelet effect of total GSs,GS-Re、GS-Rg1、GS-Rk1、GS-Rg3,and GSRp1,a derivative of GS-Rg3. GS reinforces antiplatelet drugs' function,providing its role as a potential drug candidate for thromboembolism diseases. New technology and modern perspective would guide the future research.
Multifunctions of ginsenoside(GS),including antiplatelet effect,has been found in protecting cardiovascular system. Current evidence supports the antiplatelet effect of total GSs,GS-Re、GS-Rg1、GS-Rk1、GS-Rg3,and GSRp1,a derivative of GS-Rg3. GS reinforces antiplatelet drugs' function,providing its role as a potential drug candidate for thromboembolism diseases. New technology and modern perspective would guide the future research.
引文
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[3]Sun Y Y,Liu Y,Chen K J.Roles and mechanisms of ginsenoside in cardiovascular diseases:progress and perspectives[J].Science China-Life Sciences,2016,59(3):292-298.
[4]Mega J L,Simon T.Pharmacology of antithrombotic drugs:an assessment of oral antiplatelet and anticoagulant treatments[J].Lancet,2015,386(9990):281-291.
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[9]Shin J H,Kwon H W,Cho H J,et al.Vasodilator-stimulated phosphoprotein-phosphorylation by ginsenoside Ro inhibits fibrinogen binding to alpha IIb/beta3 in thrombin-induced human platelets[J].J Ginseng Res,2016,40(4):359-365.
[10]马逢顺,高瑞兰,林筱洁,等.升血灵胶囊(人参总皂苷)治疗免疫性血小板减少症的临床研究[J].浙江中医药大学学报,2012,36(2):137-140.
[11]闫海峰,代向东,樊克涛,等.人参皂苷Re对ADP、PAF、AA诱导家兔血小板聚集功能的影响[J].天津中医药大学学报,2016,35(5):310-313.
[12]刘晓春,张瑞英.人参皂苷Re抗血小板聚集及作用机制研究[J].山西医药杂志,2015,44(14):1610-1612.
[13]Qi H,Huang Y,Yang Y,et al.Anti-platelet activity of panaxatriol saponins is mediated by suppression of intracellular calcium mobilization and ERK2/p38 activation[J].BMC Complement Altern Med,2016,16:174.
[14]Zhou Q,Jiang L,Xu C,et al.Ginsenoside Rg1inhibits platelet activation and arterial thrombosis[J].Thromb Res,2014,133(1):57-65.
[15]华声瑜,曲凤,陈丽平,等.人参皂苷Rg1对血小板聚集及环磷腺苷的影响[J].天津中医药大学学报,2012,31(1):31-33.
[16]彭茗,张瑱,张彤,等.手性人参皂苷Rg3的抗凝血和抗血小板聚集活性差异研究[J].中华中医药学刊,2015,33(9):2072-2075.
[17]Endale M,Lee W,M,Kamruzzaman S,M,et al.Ginsenoside-Rp1inhibits platelet activation and thrombus formation via impaired glycoprotein VI signalling pathway,tyrosine phosphorylation and MAPK activation[J].Br J Pharmacol,2012,167(1):109-127.
[18]Son Y,M,Jeong D,H,Park H,J,et al.The inhibitory activity of ginsenoside Rp4in adenosine diphosphate-induced platelet aggregation[J].J Ginseng Res,2017,41(1):96-102.
[19]Ju H,K,Lee J,G,Park M,K,et al.Metabolomic investigation of the anti-platelet aggregation activity of ginsenoside Rk1reveals attenuated 12-HETE production[J].J Proteome Res,2012,11(10):4939-4946.
[20]Du G,Lin Q,Wang J.A brief review on the mechanisms of aspirin resistance[J].Int J Cardiol,2016,220:21-26.
[21]Caliskan A,Karahan O,Yazici S,et al.Protective effects of ginseng extracts and common anti-aggregant drugs on ischaemia-reperfusion injury[J].Cardiovasc J Afr,2015,26(6):222-226.
[22]Willeit P,Zampetaki A,Dudek K,et al.Circulating microRNAs as novel biomarkers for platelet activation[J].Circ Res,2013,112(4):595-600.
[23]郑思道,于雯,王宁元.MicroRNA介导的人参及其活性成分药理作用与机制[J].世界中西医结合杂志,2016,11(6):880-883.
[24]郑思道,吴红金,刘宇娜.microRNA在现代中医药研究中的作用和意义[J].中西医结合心脑血管病杂志,2012,10(7):857-860.
[25]张弛,张戈,陈可冀,等.从疾病中医证候分类到分子模块分类[J].中国中西医结合杂志,2016,36(7):781-786.
[26]吴德琳,刘娟,郑思道.人参活性成分及人参复方制剂对细胞色素P450酶调节作用的研究进展[J].中西医结合心脑血管病杂志,2016,14(16):1874-1876.
[27]陈可冀.我的中西医结合六十年[J].中国中西医结合杂志,2016,36(7):773-775.
[2]Stanger M J,Thompson L A,Young A J,et al.Anticoagulant activity of select dietary supplements[J].Nutr Rev,2012,70(2):107-117.
[3]Sun Y Y,Liu Y,Chen K J.Roles and mechanisms of ginsenoside in cardiovascular diseases:progress and perspectives[J].Science China-Life Sciences,2016,59(3):292-298.
[4]Mega J L,Simon T.Pharmacology of antithrombotic drugs:an assessment of oral antiplatelet and anticoagulant treatments[J].Lancet,2015,386(9990):281-291.
[5]Gorog D A,Fuster V.Platelet function tests in clinical cardiology:unfulfilled expectations[J].J Am Coll Cardiol,2013,61(21):2115-2129.
[6]Wang M M,Xue M,Miao Y,et al.Panax quinquefolium saponin combined with dual antiplatelet drugs inhibits platelet adhesion to injured HUVECs via PI3K/AKT and COX pathways[J].J Ethnopharmacol,2016,192:10-19.
[7]Lee D H,Cho H J,Kim H H,et al.Inhibitory effects of total saponin from Korean red ginseng via vasodilator-stimulated phosphoprotein-Ser(157)phosphorylation on thrombin-induced platelet aggregation[J].J Ginseng Res,2013,37(2):176-186.
[8]Kwon H W,Shin J H,Cho H J,et al.Total saponin from Korean Red Ginseng inhibits binding of adhesive proteins to glycoprotein IIb/IIIa via phosphorylation of VASP(Ser(157))and dephosphorylation of PI3K and Akt[J].J Ginseng Res,2016,40(1):76-85.
[9]Shin J H,Kwon H W,Cho H J,et al.Vasodilator-stimulated phosphoprotein-phosphorylation by ginsenoside Ro inhibits fibrinogen binding to alpha IIb/beta3 in thrombin-induced human platelets[J].J Ginseng Res,2016,40(4):359-365.
[10]马逢顺,高瑞兰,林筱洁,等.升血灵胶囊(人参总皂苷)治疗免疫性血小板减少症的临床研究[J].浙江中医药大学学报,2012,36(2):137-140.
[11]闫海峰,代向东,樊克涛,等.人参皂苷Re对ADP、PAF、AA诱导家兔血小板聚集功能的影响[J].天津中医药大学学报,2016,35(5):310-313.
[12]刘晓春,张瑞英.人参皂苷Re抗血小板聚集及作用机制研究[J].山西医药杂志,2015,44(14):1610-1612.
[13]Qi H,Huang Y,Yang Y,et al.Anti-platelet activity of panaxatriol saponins is mediated by suppression of intracellular calcium mobilization and ERK2/p38 activation[J].BMC Complement Altern Med,2016,16:174.
[14]Zhou Q,Jiang L,Xu C,et al.Ginsenoside Rg1inhibits platelet activation and arterial thrombosis[J].Thromb Res,2014,133(1):57-65.
[15]华声瑜,曲凤,陈丽平,等.人参皂苷Rg1对血小板聚集及环磷腺苷的影响[J].天津中医药大学学报,2012,31(1):31-33.
[16]彭茗,张瑱,张彤,等.手性人参皂苷Rg3的抗凝血和抗血小板聚集活性差异研究[J].中华中医药学刊,2015,33(9):2072-2075.
[17]Endale M,Lee W,M,Kamruzzaman S,M,et al.Ginsenoside-Rp1inhibits platelet activation and thrombus formation via impaired glycoprotein VI signalling pathway,tyrosine phosphorylation and MAPK activation[J].Br J Pharmacol,2012,167(1):109-127.
[18]Son Y,M,Jeong D,H,Park H,J,et al.The inhibitory activity of ginsenoside Rp4in adenosine diphosphate-induced platelet aggregation[J].J Ginseng Res,2017,41(1):96-102.
[19]Ju H,K,Lee J,G,Park M,K,et al.Metabolomic investigation of the anti-platelet aggregation activity of ginsenoside Rk1reveals attenuated 12-HETE production[J].J Proteome Res,2012,11(10):4939-4946.
[20]Du G,Lin Q,Wang J.A brief review on the mechanisms of aspirin resistance[J].Int J Cardiol,2016,220:21-26.
[21]Caliskan A,Karahan O,Yazici S,et al.Protective effects of ginseng extracts and common anti-aggregant drugs on ischaemia-reperfusion injury[J].Cardiovasc J Afr,2015,26(6):222-226.
[22]Willeit P,Zampetaki A,Dudek K,et al.Circulating microRNAs as novel biomarkers for platelet activation[J].Circ Res,2013,112(4):595-600.
[23]郑思道,于雯,王宁元.MicroRNA介导的人参及其活性成分药理作用与机制[J].世界中西医结合杂志,2016,11(6):880-883.
[24]郑思道,吴红金,刘宇娜.microRNA在现代中医药研究中的作用和意义[J].中西医结合心脑血管病杂志,2012,10(7):857-860.
[25]张弛,张戈,陈可冀,等.从疾病中医证候分类到分子模块分类[J].中国中西医结合杂志,2016,36(7):781-786.
[26]吴德琳,刘娟,郑思道.人参活性成分及人参复方制剂对细胞色素P450酶调节作用的研究进展[J].中西医结合心脑血管病杂志,2016,14(16):1874-1876.
[27]陈可冀.我的中西医结合六十年[J].中国中西医结合杂志,2016,36(7):773-775.