朝药材柞树皮的化学成分研究
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摘要
[目的]分析朝药材柞树皮的化学成分.[方法]采用多种柱层析和重结晶的方法分离纯化柞树皮的化学成分,利用核磁共振波谱法(1 H-NMR和13C-NMR)结合理化性质对所得单体化合物进行结构鉴定.[结果]从柞树皮二氯甲烷提取物中分离得到10个单体化合物,分别为β-谷甾醇(1)、3β,16α,28-trihydroxyolean-12-en-21-one(2)、阿江榄仁酸(3)、3,4-二羟基苯乙醇(4)、3,4-二羟基苯乙醇醋酸酯(5)、1,2-benzenediol-4-(1,2-dimethoxyethyl)(6)、东莨菪素(7)、它乔糖甙(8)、东莨菪苷(9)和秦皮苷(10).[结论]化合物2~6,9,10为首次从该植物中分离得到.
OBJECTIVETo analyze the chemical constituents of cortex Quercus mongolicaof Korean folk medicine.METHODSA variety of column chromatography and recrystallization methods were used to isolate and purify the chemical constituents of cortex Quercus mongolica.Their stuctures were identified by NMR spectroscopy(1 H-HMR and 13 C-NMR)and physical and chemical properties.RESULTS 10 monomer compounds were isolated from cortex Quercusmongolica dichloromethane extract,they wereβ-sitosterol(1),3β,16α,28-trihydroxyolean-12-en-21-one(2),arjunolic acid(3),3,4-dihydroxyphenylethanol(4),3,4-dihydroxytyrosol acetate(5),1,2-benzenediol-4-(1,2-dimethoxyethyl)(6),scopoletin(7),tachioside(8),scopolin(9)and fraxin(10).CONCLUSIONCompounds 2-6,9 and 10 were isolated for the first time from this plant.
OBJECTIVETo analyze the chemical constituents of cortex Quercus mongolicaof Korean folk medicine.METHODSA variety of column chromatography and recrystallization methods were used to isolate and purify the chemical constituents of cortex Quercus mongolica.Their stuctures were identified by NMR spectroscopy(1 H-HMR and 13 C-NMR)and physical and chemical properties.RESULTS 10 monomer compounds were isolated from cortex Quercusmongolica dichloromethane extract,they wereβ-sitosterol(1),3β,16α,28-trihydroxyolean-12-en-21-one(2),arjunolic acid(3),3,4-dihydroxyphenylethanol(4),3,4-dihydroxytyrosol acetate(5),1,2-benzenediol-4-(1,2-dimethoxyethyl)(6),scopoletin(7),tachioside(8),scopolin(9)and fraxin(10).CONCLUSIONCompounds 2-6,9 and 10 were isolated for the first time from this plant.
引文
[1]吉林省中医中药研究所.长白山植物药志[M].长春:吉林人民出版社,1982:896-899.
[2]姚佳,张中伟,宋鑫,等.柞树枝化学成分研究[J].齐齐哈尔大学学报,2012,28(6):30-32.
[3]张国友,唐玲,陈玮,等.分光光度法测定蒙古栎叶中多酚的含量[J].中国科学院研究生院学报,2009,26(3):319-322.
[4]王耀辉,盂庆繁,孙广仁.蒙古栎叶挥发性成分的分析[J].东北林业大学学报,2006,34(4):37-39.
[5]周立红,孙启时,乔丽川,等.栓皮栎叶抗炎活性部位中化学成分的初步研究[J].沈阳药科大学学报,2000,17(3):179-181.
[6]Wang MK,Cai H,Peng SL,et al..Triterpenoid saponins from Berneuxia Thebetica[J].Phytochemistry,1998,48(8):1411-1414.
[7]孙娟,金英今,徐博,等.尾叶香茶菜的化学成分及其活性的研究[J].延边大学学报:自然科学版,2014,40(2):186-188.
[8]Bernini R,Mincione E,Barontini M,et al..Convenient synthesis of hydroxytyrosol and its lipophilic derivatives from tyrosol or homovanillyl alcohol[J].J Agric Food Chem,2008,56(19):8897-8904.
[9]张莉,裴栋,黄炎如,等.锁阳化学成分研究[J].中药材,2016,39(1):74-77.
[10]Luo D,Or TC,Yang CL.Anti-inflammatory activity of iridoid and catechol derivatives from Eucommia ulmoides Oliver[J].ACS Chem Neurosci,2014,5(9):855-866.
[11]朱伟明,尹成芳.美飞蛾藤(Porana spectabilis Kurz)植物中的化学成分[J].天然产物研究与开发,2001,13(5):1-4.
[12]岳跃栋.双斑獐牙菜和八角枫的化学成分与生物活性研究[D].华中科技大学,2016.
[13]李行诺,楚楚,毛慧琼,等.地骨皮化学成分研究[J].中国现代应用药学,2012,29(9):805-808.
[14]Liu LM,Wang RH,Chen L,et al..Study on the chemical constituents in Ervatamia hainanensi[J].Chin Tradit Herb Drugs,2003,34(10):889-980.
[2]姚佳,张中伟,宋鑫,等.柞树枝化学成分研究[J].齐齐哈尔大学学报,2012,28(6):30-32.
[3]张国友,唐玲,陈玮,等.分光光度法测定蒙古栎叶中多酚的含量[J].中国科学院研究生院学报,2009,26(3):319-322.
[4]王耀辉,盂庆繁,孙广仁.蒙古栎叶挥发性成分的分析[J].东北林业大学学报,2006,34(4):37-39.
[5]周立红,孙启时,乔丽川,等.栓皮栎叶抗炎活性部位中化学成分的初步研究[J].沈阳药科大学学报,2000,17(3):179-181.
[6]Wang MK,Cai H,Peng SL,et al..Triterpenoid saponins from Berneuxia Thebetica[J].Phytochemistry,1998,48(8):1411-1414.
[7]孙娟,金英今,徐博,等.尾叶香茶菜的化学成分及其活性的研究[J].延边大学学报:自然科学版,2014,40(2):186-188.
[8]Bernini R,Mincione E,Barontini M,et al..Convenient synthesis of hydroxytyrosol and its lipophilic derivatives from tyrosol or homovanillyl alcohol[J].J Agric Food Chem,2008,56(19):8897-8904.
[9]张莉,裴栋,黄炎如,等.锁阳化学成分研究[J].中药材,2016,39(1):74-77.
[10]Luo D,Or TC,Yang CL.Anti-inflammatory activity of iridoid and catechol derivatives from Eucommia ulmoides Oliver[J].ACS Chem Neurosci,2014,5(9):855-866.
[11]朱伟明,尹成芳.美飞蛾藤(Porana spectabilis Kurz)植物中的化学成分[J].天然产物研究与开发,2001,13(5):1-4.
[12]岳跃栋.双斑獐牙菜和八角枫的化学成分与生物活性研究[D].华中科技大学,2016.
[13]李行诺,楚楚,毛慧琼,等.地骨皮化学成分研究[J].中国现代应用药学,2012,29(9):805-808.
[14]Liu LM,Wang RH,Chen L,et al..Study on the chemical constituents in Ervatamia hainanensi[J].Chin Tradit Herb Drugs,2003,34(10):889-980.