冠心病心肌重构的研究进展
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摘要
近些年来研究表明心肌梗死后心脏重构的现象严重,包括结构重构,心电重构,神经重构等。在急性心肌梗死幸存人群中,仍有多数人因致命性心律失常或难治性心力衰竭而死亡。心肌梗死后,心脏发生了诸多病理生理变化,有研究表明炎性因子过度激活、各种离子通道蛋白的异常,以及信号通路的改变促进了心肌各种重构现象的发生。
In recent years,numerous studies have shown that cardiac remodeling after myocardial infarction( MI) is a serious phenomenon,including structural remodeling,atrial electrical remodeling( AER),and neural remodeling. Most of the survivors of acute MI still die of fatal arrhythmias or refractory heart failure. MI leads to a variety of pathophysiological changes in the heart. Th studies have shown that excessive activation of inflammatory factors,abnormalities of various ion channel proteins,as well as the changes of signaling pathways promote various myocardial remodeling.
In recent years,numerous studies have shown that cardiac remodeling after myocardial infarction( MI) is a serious phenomenon,including structural remodeling,atrial electrical remodeling( AER),and neural remodeling. Most of the survivors of acute MI still die of fatal arrhythmias or refractory heart failure. MI leads to a variety of pathophysiological changes in the heart. Th studies have shown that excessive activation of inflammatory factors,abnormalities of various ion channel proteins,as well as the changes of signaling pathways promote various myocardial remodeling.
引文
1 Bulow HP,Stahl F,Iauer B,et al.Alterations of myocardial presynaptic sympathetic innervation in patients with multi-vessel coronary artery disease but without history of myocardial infarction.Nucl Med Commun,2003,24:233-239.
2 Luisi AJ Jr,Fallavollita JA,Suzuki G,et al.Spatial inhomogeneity of nervefunction in hibernating myocardium.Circulalion,2002,106:779-781.
3 余涛,李京波,朱伟,等.辛伐他汀对大鼠心肌梗死后交感神经重构和室性心律失常的影响.实用医学杂志,2012,12:1958-1960.
4 闫文,金鹏.心肌梗死后心脏交感神经重构与生长相关蛋白-43、神经生长因子(NGF)的研究进展.中国伤残医学,2013,21:461-463.
5 李明辉,刘喜.急性心梗后NGF导致的心脏交感神经重构与室性心律失常的关系.内蒙古医学杂志,2016,48:49-52.
6 方帆,蒋桔泉.炎症反应与心肌梗死后交感神经重构.临床心血管病杂志,2015,31:276-279.
7 陈波,王卫.β-受体阻断剂比索洛尔早期应用于心肌梗死对心脏自主神经重构的影响分析.中国实用神经疾病杂志,2015,18:101-103.
8 郑武扬,李卫华,谢强,等.青蒿素对大鼠心梗后交感神经重构的影响及其机制研究.中国生化药物杂志,2015,35:81-84.
9 Schlaich MP,Sobotka PA,Krum H,et al.Renal sympathetic nerve ablation for uncontrolled hypertension.N Engl J Med,2009,361:932-934.
10 黄颖.射频消融损毁冠状静脉周围交感神经对心肌梗死犬心室电生理特性的影响.第二军医大学,2016.
11 邵承颖,苏冉,王琳,等.有氧运动对心肌梗死大鼠心脏交感神经重构的影响.山东体育学院学报,2015,31:73-77.
12 陈婷,田振军.有氧运动抑制心梗心脏TNF-α/NF-κB/NGF-Trk A通路降低心交感神经重构.中国体育科学学会.2015第十届全国体育科学大会论文摘要汇编(一).中国体育科学学会,2015.
13 Tsumoto K,Ashihara T,Haraguchi R,et al.Ischemia-related subcellular redistribution of sodium channels enhances the proarrhythmic effect of class I antiarrhythmic drugs:A simulation study.PLOS ONE,2014,9:e109271.
14 边波.阿托伐他汀对正常/模拟缺血/再灌注心室肌快钠电流影响的系列研究.天津医科大学,2011.
15 刘长城,顾承雄.心肌细胞异质性与心肌梗死后相关室性心律失常关系的研究进展.心肺血管病杂志,2015,34:664-667.
16 贺鹏康,霍勇,周菁,等.晚钠电流抑制剂对心房间传导的影响及其抗心房颤动作用的机制探讨.中华心律失常学杂志,2014,18:52-56.
17 董炳庆,闫素华,王晔,等.糖尿病兔心肌梗死后钾离子通道蛋白基因表达的变化.中国病理生理杂志,2011,27:1777-1780.
18 Swissa M,Zhou S,Gonzalez-Gomez I,et al.Long-term subthrexhold electrical stimulation of the left stellate ganglion and acanine modelofsudden cardiac death.J ACC,2004,43:858-864.
19 Liu CF,Liu EL,Luo TE,et al.Opening of the inward rectifier potassium channel alleviates maladaptive tissue repair following myocardial infraction.Acta Biochim Biophys Sin(Shanghai),2016,48:687-695.
20 王书娟,董金军,王建良,等.阿托伐他汀对急性心肌梗死后1周兔心室肌细胞L-钙离子通道电流的影响.中国医药科学,2011,1:28-29,49.
21 Beauchamp P,Desplantez T,Mc Cain ML,et al.Electrical coupling and propagation in engineered ventricular myocardium with heterogeneous expression of connexin43.Circ Res,2012,110:1445-1453.
22 牛少辉.替米沙坦对大鼠急性心肌梗死Cx43及TNF-α的影响.郑州大学,2010.
23 Danik SB,Liu F,Zhang J,et al.Modulation of cardiac gap junction expression and arrhythmic susceptibility.Circ Res,2004,95:1035-1041.
24 Kjolbye AL,Dikshteyn M,Eloff BC,et al.Maintenance of intercellular coupling by the antiarrhythmic peptide rotigaptide suppresses arrhythmogenic discordant alternans.Am J Physiol Heart Circ Physiol,2008,294:H41-H49.
25 赵静,吴林.心脏复极储备异常与恶性室性心律失常.心血管病学进展,2013,34:23-26.
26 李帅,李京波,朱伟,等.辛伐他汀对大鼠心肌梗死后心室电重构及室颤阈值的影响.上海交通大学学报(医学版),2011,31:425-428,433.
27 张坤,李广平,李健,等.依折麦布和辛伐他汀对缺血再灌注大鼠心肌细胞瞬时外向钾电流的影响.天津医药,2015,43:1296-1299.
28 Davis J,Molkentin JD.Myofibroblasts:trust your heart and let fate decide.J Mol Cell Cardiol,2014,70:9-18.
29 Cooklin M,Wallis WRJ,Sheridan DJ,et al.Changes in cell-tocell electrical coupling associated with left ventricular hypertrophy.Circ Res,1997,80:765-771.
30 Dhein S,Seidel T,Salameh A,et al.Remodeling of cardiac passive electrical properties and susceptibility to ventricular and atrial arrhythmias.Front Physiol,2014,5:424.
31 郑熙,朱鹏立,余惠珍.组织基质金属蛋白酶系统与心室重塑.大连医科大学学报,2016,38:407-411.
32 吴春涛,马士新.瑞舒伐他汀对急性心肌梗死大鼠心肌重构的作用及其机制.中国循证心血管医学杂志,2016,8:560-563.
33 袁明杰,孔彬,权力,等.Ghrelin对大鼠心肌梗死后血管重构的影响及机制研究.中国医药导报,2013,10:4-6,9.
34 苗磊,刘培良.干细胞治疗缺血性心脏病.中国组织工程研究,2016,20:906-912.
35 黄峻.慢性心衰治疗的基本理念:过去、现在和未来.天津医药,2016,44:929-931.
36 袁明杰,孔彬,权力,等.Ghrelin对大鼠心肌梗死后血管重构的影响及机制研究.中国医药导报,2013,10:4-6,9.
37 胡红耀.Ghrelin系统在心肌梗死后心脏重构中的作用及机制研究.武汉大学,2012.
38 Malliaras K,Makkar RR,Smith RR,et al.Intracoronary cardiospherederived cells after myocardialinfarction:evidence of therapeutic regeneration in the finall-year results of the CADUCEUS trial(Cardiosphere-Derived autologous stem cells to reverse ventricular dysfunction).J Am Coll Cardiol,2014,63:110-122.
39 史沛.MMP-8在心肌缺血再灌注损伤和心室重塑中的作用及机制研究.郑州大学,2015.
40 王占启,李向欣,贾辛未,等.急性前壁心肌梗死KillipⅡ~Ⅲ级患者直接PCI后重组人脑利钠肽干预对心肌重构的阻抑作用.中国老年学杂志,2016,36:4212-4214.
2 Luisi AJ Jr,Fallavollita JA,Suzuki G,et al.Spatial inhomogeneity of nervefunction in hibernating myocardium.Circulalion,2002,106:779-781.
3 余涛,李京波,朱伟,等.辛伐他汀对大鼠心肌梗死后交感神经重构和室性心律失常的影响.实用医学杂志,2012,12:1958-1960.
4 闫文,金鹏.心肌梗死后心脏交感神经重构与生长相关蛋白-43、神经生长因子(NGF)的研究进展.中国伤残医学,2013,21:461-463.
5 李明辉,刘喜.急性心梗后NGF导致的心脏交感神经重构与室性心律失常的关系.内蒙古医学杂志,2016,48:49-52.
6 方帆,蒋桔泉.炎症反应与心肌梗死后交感神经重构.临床心血管病杂志,2015,31:276-279.
7 陈波,王卫.β-受体阻断剂比索洛尔早期应用于心肌梗死对心脏自主神经重构的影响分析.中国实用神经疾病杂志,2015,18:101-103.
8 郑武扬,李卫华,谢强,等.青蒿素对大鼠心梗后交感神经重构的影响及其机制研究.中国生化药物杂志,2015,35:81-84.
9 Schlaich MP,Sobotka PA,Krum H,et al.Renal sympathetic nerve ablation for uncontrolled hypertension.N Engl J Med,2009,361:932-934.
10 黄颖.射频消融损毁冠状静脉周围交感神经对心肌梗死犬心室电生理特性的影响.第二军医大学,2016.
11 邵承颖,苏冉,王琳,等.有氧运动对心肌梗死大鼠心脏交感神经重构的影响.山东体育学院学报,2015,31:73-77.
12 陈婷,田振军.有氧运动抑制心梗心脏TNF-α/NF-κB/NGF-Trk A通路降低心交感神经重构.中国体育科学学会.2015第十届全国体育科学大会论文摘要汇编(一).中国体育科学学会,2015.
13 Tsumoto K,Ashihara T,Haraguchi R,et al.Ischemia-related subcellular redistribution of sodium channels enhances the proarrhythmic effect of class I antiarrhythmic drugs:A simulation study.PLOS ONE,2014,9:e109271.
14 边波.阿托伐他汀对正常/模拟缺血/再灌注心室肌快钠电流影响的系列研究.天津医科大学,2011.
15 刘长城,顾承雄.心肌细胞异质性与心肌梗死后相关室性心律失常关系的研究进展.心肺血管病杂志,2015,34:664-667.
16 贺鹏康,霍勇,周菁,等.晚钠电流抑制剂对心房间传导的影响及其抗心房颤动作用的机制探讨.中华心律失常学杂志,2014,18:52-56.
17 董炳庆,闫素华,王晔,等.糖尿病兔心肌梗死后钾离子通道蛋白基因表达的变化.中国病理生理杂志,2011,27:1777-1780.
18 Swissa M,Zhou S,Gonzalez-Gomez I,et al.Long-term subthrexhold electrical stimulation of the left stellate ganglion and acanine modelofsudden cardiac death.J ACC,2004,43:858-864.
19 Liu CF,Liu EL,Luo TE,et al.Opening of the inward rectifier potassium channel alleviates maladaptive tissue repair following myocardial infraction.Acta Biochim Biophys Sin(Shanghai),2016,48:687-695.
20 王书娟,董金军,王建良,等.阿托伐他汀对急性心肌梗死后1周兔心室肌细胞L-钙离子通道电流的影响.中国医药科学,2011,1:28-29,49.
21 Beauchamp P,Desplantez T,Mc Cain ML,et al.Electrical coupling and propagation in engineered ventricular myocardium with heterogeneous expression of connexin43.Circ Res,2012,110:1445-1453.
22 牛少辉.替米沙坦对大鼠急性心肌梗死Cx43及TNF-α的影响.郑州大学,2010.
23 Danik SB,Liu F,Zhang J,et al.Modulation of cardiac gap junction expression and arrhythmic susceptibility.Circ Res,2004,95:1035-1041.
24 Kjolbye AL,Dikshteyn M,Eloff BC,et al.Maintenance of intercellular coupling by the antiarrhythmic peptide rotigaptide suppresses arrhythmogenic discordant alternans.Am J Physiol Heart Circ Physiol,2008,294:H41-H49.
25 赵静,吴林.心脏复极储备异常与恶性室性心律失常.心血管病学进展,2013,34:23-26.
26 李帅,李京波,朱伟,等.辛伐他汀对大鼠心肌梗死后心室电重构及室颤阈值的影响.上海交通大学学报(医学版),2011,31:425-428,433.
27 张坤,李广平,李健,等.依折麦布和辛伐他汀对缺血再灌注大鼠心肌细胞瞬时外向钾电流的影响.天津医药,2015,43:1296-1299.
28 Davis J,Molkentin JD.Myofibroblasts:trust your heart and let fate decide.J Mol Cell Cardiol,2014,70:9-18.
29 Cooklin M,Wallis WRJ,Sheridan DJ,et al.Changes in cell-tocell electrical coupling associated with left ventricular hypertrophy.Circ Res,1997,80:765-771.
30 Dhein S,Seidel T,Salameh A,et al.Remodeling of cardiac passive electrical properties and susceptibility to ventricular and atrial arrhythmias.Front Physiol,2014,5:424.
31 郑熙,朱鹏立,余惠珍.组织基质金属蛋白酶系统与心室重塑.大连医科大学学报,2016,38:407-411.
32 吴春涛,马士新.瑞舒伐他汀对急性心肌梗死大鼠心肌重构的作用及其机制.中国循证心血管医学杂志,2016,8:560-563.
33 袁明杰,孔彬,权力,等.Ghrelin对大鼠心肌梗死后血管重构的影响及机制研究.中国医药导报,2013,10:4-6,9.
34 苗磊,刘培良.干细胞治疗缺血性心脏病.中国组织工程研究,2016,20:906-912.
35 黄峻.慢性心衰治疗的基本理念:过去、现在和未来.天津医药,2016,44:929-931.
36 袁明杰,孔彬,权力,等.Ghrelin对大鼠心肌梗死后血管重构的影响及机制研究.中国医药导报,2013,10:4-6,9.
37 胡红耀.Ghrelin系统在心肌梗死后心脏重构中的作用及机制研究.武汉大学,2012.
38 Malliaras K,Makkar RR,Smith RR,et al.Intracoronary cardiospherederived cells after myocardialinfarction:evidence of therapeutic regeneration in the finall-year results of the CADUCEUS trial(Cardiosphere-Derived autologous stem cells to reverse ventricular dysfunction).J Am Coll Cardiol,2014,63:110-122.
39 史沛.MMP-8在心肌缺血再灌注损伤和心室重塑中的作用及机制研究.郑州大学,2015.
40 王占启,李向欣,贾辛未,等.急性前壁心肌梗死KillipⅡ~Ⅲ级患者直接PCI后重组人脑利钠肽干预对心肌重构的阻抑作用.中国老年学杂志,2016,36:4212-4214.