浅谈COPD表型与中医证型的相关性
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摘要
[目的]论述部分COPD表型与中医证型的相关性。[方法]通过检索近年来COPD表型研究相关文献,结合中医理论,对部分COPD表型与中医证型存在的关系进行探讨。[结果]慢性支气管炎及频繁急性加重表型、肺气肿表型、全身炎症表型、FEV1快速下降表型、重叠综合症表型分别可能对应中医寒痰阻肺、肺肾气虚、痰热壅肺、痰瘀阻肺、痰热瘀互结证型。[结论]提出COPD表型与中医证型在概念构成、影响因素、分型目的上存在某种程度的相似性,强调COPD患者的分层治疗,提供中医药在COPD防治工作方面的理论依据,为COPD的系统研究提供思路。
[Objective] Discussing the relationship between COPD phenotypes and patterns of TCM.[Methods] Discussing the relationship by searching of documents about research of COPD phenotypes.[Result]The phenotype of chronicbronchitis and exacerbation,emphysema,inflammation,FEV1 declining or overlap syndrome may match with different patterns of TCM.[Conclusion] COPD phenotypes have similarities with patterns of TCM at component,influence and typing target.
[Objective] Discussing the relationship between COPD phenotypes and patterns of TCM.[Methods] Discussing the relationship by searching of documents about research of COPD phenotypes.[Result]The phenotype of chronicbronchitis and exacerbation,emphysema,inflammation,FEV1 declining or overlap syndrome may match with different patterns of TCM.[Conclusion] COPD phenotypes have similarities with patterns of TCM at component,influence and typing target.
引文
[1]中华医学会呼吸病学分会慢性阻塞性肺疾病学组.慢性阻塞性肺疾病诊治指南(2013年修订版)[J].中华结核和呼吸杂志,2013,36(4):255-264.
[2]P-R.Burgel,J-L.Paillasseur,D.Caillaud,Clinical COPD phenotypes:a novel approach using principal component and cluster analyses[J].European Respiratory Journal,2010(36):531-539.
[3]Anderson D,Macnee W.Targeted treatment in COPD:a multi-system approach for a multi-system disease[J].Int J Chron Obstruct Pulmon Dis,2009(4):321-335.
[4]陈亚红,姚婉贞.慢性阻塞性肺疾病表型的研究进展[J].中华结核和呼吸杂志,2011,34(8):619-622.
[5]Han MK,Agusti A,calverley PM,et a1.Chronic obstructive pulmonary disease phenotypes:the future of COPD[J].Am J Respir Crit Care Med,2010(182);598-604.
[6]Sobradillo P,García-Aymerich J,Agustíà.Clinical phenotypes of COPD[J].Arch Bronconeumol,2010(11):8-11.
[7]Judith Garcia-Aymericha,Federico P Gómezb,Josep M Antóa.Phenotypic Characterization and Course of Chronic Obstructive Pulmonary Disease in the PAC-COPD Study:Design and Methods[J].Archivos de Bronconeumología((English Edition)),2009,(45):4-11.
[8]朱文锋.中医诊断学[M].北京:中国中医药出版社,2007:2.
[9]Li An,Ting Yang,Yongbiao Zhang,et al.Association of SERPINE2 gene with the risk of chronic obstructive pulmonary disease and spirometric phenotypes in northern Han Chinese population[J].Mol Biol Rep,2012,39:1427-1433.
[10]M.K.Han,E.A.Kazerooni,D.A.Lynch,et al.COPD Gene研究:与慢性阻塞性肺疾病急性发作相关的影像学表型[J].国际医学放射学杂志,2011,34(6):594.
[11]孙雯,孙兴国,彭立悦,等.不同表型的慢性阻塞性肺疾病患者运动能力的比较[J].中国实用内科杂志,2013,33(sl):51.
[12]吴饶仙,况九龙.慢性阻塞性肺疾病临床表型的研究进展[J].Med J Chin PLA,2013(6):519-523.
[13]李然,白澎,孙永昌,等.慢性阻塞性肺疾病肺气肿表型的临床与病理生理特征分析[J].中华结合和呼吸杂志,2011,34(11):857-858.
[14]陈望月,郑碧霞,程德云.慢性阻塞性肺疾病的表型及其意义[J].临床荟萃,2013,28(8):934-937.
[15]王坤根.补肺益肾方治疗慢性阻塞性肺疾病稳定期临床研究[J].中国中西医结合杂志,2004,24(6):555-556.
[16]李文,毛兵,王刚,等.从气道炎症和气道粘液高分泌研究清热化痰法治疗慢性阻塞性肺疾病急性加重期痰热阻肺证的机制[J].中西医结合学报,2008,6(8):799-805.
[17]FlenleyDC.Sleep in chronic obstructive lung disease[J].Clin Chest Med,1985,(6):651-661.
[18]杨秀云,周建英.重叠综合症[J].国际呼吸杂志.2007,27(2):146-149.
[19]刘世清,麻宵萍.睡眠呼吸暂停综合征与各系统疾病的关系[J].山东医药,2008,48(34):110-111.
[2]P-R.Burgel,J-L.Paillasseur,D.Caillaud,Clinical COPD phenotypes:a novel approach using principal component and cluster analyses[J].European Respiratory Journal,2010(36):531-539.
[3]Anderson D,Macnee W.Targeted treatment in COPD:a multi-system approach for a multi-system disease[J].Int J Chron Obstruct Pulmon Dis,2009(4):321-335.
[4]陈亚红,姚婉贞.慢性阻塞性肺疾病表型的研究进展[J].中华结核和呼吸杂志,2011,34(8):619-622.
[5]Han MK,Agusti A,calverley PM,et a1.Chronic obstructive pulmonary disease phenotypes:the future of COPD[J].Am J Respir Crit Care Med,2010(182);598-604.
[6]Sobradillo P,García-Aymerich J,Agustíà.Clinical phenotypes of COPD[J].Arch Bronconeumol,2010(11):8-11.
[7]Judith Garcia-Aymericha,Federico P Gómezb,Josep M Antóa.Phenotypic Characterization and Course of Chronic Obstructive Pulmonary Disease in the PAC-COPD Study:Design and Methods[J].Archivos de Bronconeumología((English Edition)),2009,(45):4-11.
[8]朱文锋.中医诊断学[M].北京:中国中医药出版社,2007:2.
[9]Li An,Ting Yang,Yongbiao Zhang,et al.Association of SERPINE2 gene with the risk of chronic obstructive pulmonary disease and spirometric phenotypes in northern Han Chinese population[J].Mol Biol Rep,2012,39:1427-1433.
[10]M.K.Han,E.A.Kazerooni,D.A.Lynch,et al.COPD Gene研究:与慢性阻塞性肺疾病急性发作相关的影像学表型[J].国际医学放射学杂志,2011,34(6):594.
[11]孙雯,孙兴国,彭立悦,等.不同表型的慢性阻塞性肺疾病患者运动能力的比较[J].中国实用内科杂志,2013,33(sl):51.
[12]吴饶仙,况九龙.慢性阻塞性肺疾病临床表型的研究进展[J].Med J Chin PLA,2013(6):519-523.
[13]李然,白澎,孙永昌,等.慢性阻塞性肺疾病肺气肿表型的临床与病理生理特征分析[J].中华结合和呼吸杂志,2011,34(11):857-858.
[14]陈望月,郑碧霞,程德云.慢性阻塞性肺疾病的表型及其意义[J].临床荟萃,2013,28(8):934-937.
[15]王坤根.补肺益肾方治疗慢性阻塞性肺疾病稳定期临床研究[J].中国中西医结合杂志,2004,24(6):555-556.
[16]李文,毛兵,王刚,等.从气道炎症和气道粘液高分泌研究清热化痰法治疗慢性阻塞性肺疾病急性加重期痰热阻肺证的机制[J].中西医结合学报,2008,6(8):799-805.
[17]FlenleyDC.Sleep in chronic obstructive lung disease[J].Clin Chest Med,1985,(6):651-661.
[18]杨秀云,周建英.重叠综合症[J].国际呼吸杂志.2007,27(2):146-149.
[19]刘世清,麻宵萍.睡眠呼吸暂停综合征与各系统疾病的关系[J].山东医药,2008,48(34):110-111.