消斑颗粒联合面部围刺及黄芪注射治疗脾虚型黄褐斑临床研究
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摘要
目的:研究中药颗粒口服联合面部皮损围刺及穴位注射的方法治疗脾虚型黄褐斑的临床疗效,观察并统计围刺结合穴位注射治疗黄褐斑的不良反应,探讨其临床治疗黄褐斑的可行性。方法:将符合纳入标准的90例脾虚型黄褐斑患者采用随机数字表法随机分为西药组、中药组、中医综合组,每组30例。西药组:口服维生素E丸、维生素C丸,外用2%氢醌乳膏治疗。中药组:口服由辽宁中医药大学附属第二医院药房加工之中药颗粒剂,外用2%氢醌乳膏治疗。中医综合组:在中药组口服中药颗粒剂的基础上,结合面部围刺和黄芪穴位注射治疗。综合患者皮损颜色、面积评分、中医主要兼症指标评分及总有效率,进行统计学分析。结果:3组患者综合疗效分析的比较:中医综合治疗组的总有效率明显高于西药组及中药组(P<0.05);中药组的总有效率明显高于西药组(P<0.05)。3组患者治疗前后皮损评分的比较:中医综合治疗组的皮损评分明显低于西药组及中药组(P<0.05);中药组的皮损评分明显低于西药组(P<0.05)。3组中医主要兼症评分比较:中医综合治疗组中医主要兼症评分明显低于西药组及中药组(P<0.05);中药组的中医主要兼症评分明显低于西药组(P<0.05)。结论:中药颗粒口服联合面部皮损围刺及穴位注射的方法治疗脾虚型黄褐斑的临床疗效好,未见明显的不良反应,值得在临床上推广使用。
Objective:To study the clinical efficacy of traditional Chinese medicine granules combined with facial skin lesions and acupoint injection in the treatment of spleen deficiency type chloasma. And to observe and count the adverse reactions of pericarp and acupoint injection in the treatment of chloasma,and explore its clinical feasibility of treating chloasma. Methods:90 patients with spleen-deficiency chloasma who met the inclusion criteria were randomly divided into Western medicine group,traditional Chinese medicine group and traditional Chinese medicine comprehensive group by random number table,30 cases in each group. Western medicine group:oral vitamin E pills,vitamin C pills,topical 2% hydroquinone cream treatment. Chinese medicine group:oral treatment of Chinese medicine granules by the hospital pharmacy,topical 2% hydroquinone cream. Traditional Chinese medicine comprehensive group:based on the oral Chinese medicine granules in the traditional Chinese medicine group,combined with facial acupuncture and acupoint injection. Statistical analysis was performed on the color and area scores of the patients' lesions,the scores of the main symptoms of the Chinese medicine,and the total effective rate. Results:The comprehensive efficacy analysis of the three groups of patients:the total effective rate of the TCM comprehensive treatment group was significantly higher than the Western medicine group and the Chinese medicine group(P<0.05);the total effective rate of the Chinese medicine group was significantly higher than the Western medicine group(P<0.05). The lesion scores of the three groups before and after treatment were significantly lower than those of the Western medicine group and the traditional Chinese medicine group(P<0.05). The lesion score of the traditional Chinese medicine group was significantly lower than that of the Western medicine group(P<0.05). The main scores of the three groups of Chinese medicine were compared:the main symptom scores of TCM comprehensive treatment group were significantly lower than those of Western medicine group and Chinese medicine group(P<0.05);the main symptom scores of traditional Chinese medicine in Chinese medicine group were significantly lower than those of western medicine group(P<0.05). Conclusion:Traditional Chinese medicine granule combined with facial skin lesions and acupoint injection for the treatment of spleen deficiency type chloasma has good clinical efficacy,no obvious adverse reactions,and it is worthy of clinical use.
Objective:To study the clinical efficacy of traditional Chinese medicine granules combined with facial skin lesions and acupoint injection in the treatment of spleen deficiency type chloasma. And to observe and count the adverse reactions of pericarp and acupoint injection in the treatment of chloasma,and explore its clinical feasibility of treating chloasma. Methods:90 patients with spleen-deficiency chloasma who met the inclusion criteria were randomly divided into Western medicine group,traditional Chinese medicine group and traditional Chinese medicine comprehensive group by random number table,30 cases in each group. Western medicine group:oral vitamin E pills,vitamin C pills,topical 2% hydroquinone cream treatment. Chinese medicine group:oral treatment of Chinese medicine granules by the hospital pharmacy,topical 2% hydroquinone cream. Traditional Chinese medicine comprehensive group:based on the oral Chinese medicine granules in the traditional Chinese medicine group,combined with facial acupuncture and acupoint injection. Statistical analysis was performed on the color and area scores of the patients' lesions,the scores of the main symptoms of the Chinese medicine,and the total effective rate. Results:The comprehensive efficacy analysis of the three groups of patients:the total effective rate of the TCM comprehensive treatment group was significantly higher than the Western medicine group and the Chinese medicine group(P<0.05);the total effective rate of the Chinese medicine group was significantly higher than the Western medicine group(P<0.05). The lesion scores of the three groups before and after treatment were significantly lower than those of the Western medicine group and the traditional Chinese medicine group(P<0.05). The lesion score of the traditional Chinese medicine group was significantly lower than that of the Western medicine group(P<0.05). The main scores of the three groups of Chinese medicine were compared:the main symptom scores of TCM comprehensive treatment group were significantly lower than those of Western medicine group and Chinese medicine group(P<0.05);the main symptom scores of traditional Chinese medicine in Chinese medicine group were significantly lower than those of western medicine group(P<0.05). Conclusion:Traditional Chinese medicine granule combined with facial skin lesions and acupoint injection for the treatment of spleen deficiency type chloasma has good clinical efficacy,no obvious adverse reactions,and it is worthy of clinical use.
引文
[1]姜群群,刘玲玲,刘卫兵.黄褐斑的中西医研究进展[J].中医临床研究,2017,9(16):145-148.
[2]中国中西医结合学会皮肤性病专业委员会色素病学组.黄褐斑及白瘫风诊疗标准(2010年版)[J].中华皮肤科杂志,2010(6):343.
[3]王忆勤.中医诊断学[M].北京:中国中医药出版社,2004:163.
[4]李日庆.中医外科学[M].北京:中国中医药出版社,2002:205-207.
[5]赵晓琴.黄褐斑的辨证分型治疗[J].辽宁中医杂志,2002,29(7):444-445.
[6]吴慧金,林光丽,张宏伟.消斑片治疗黄褐斑60例疗效观察[J].新中医,2004,36(1):44-45.
[7]万克英,罗丽芳,于广松.复方活血汤治疗黄褐斑的临床观察及对性激素的影响[J].中国皮肤病学杂志,2004,18(6):368-369.
[8]晏淑梅.中医辨治面部黄褐斑的点滴体会[J].四川中医,2004,22(2):78-79.
[9]林宝珍,陈友义,陈芳,等.中药J105退斑润白面膜治疗黄褐斑60例[J].福建中医药,2004,35(5):30.
[10]刘保国,李志英,李保卫,等.复方杏仁面膜对黄褐斑患者血清SOD,MDA的影响[J].中国实验方剂学杂志,2008,14(9):682-686.
[11]余蕾.针刺加耳穴贴压治疗黄褐斑59例疗效观察[J].中国针灸,2000,20(9):45.
[12]肖平,孙远征,侯慧先.督脉埋针治疗女性黄褐斑的临床研究[J].针灸临床杂志,2005,21(6):21-22.
[13]周永忠.穴位注射加局部围刺治疗黄褐斑46例[J].中国针灸,2007,27(S1):50.
[14]刘文国.刮瘩、刺血拔罐治疗面部黄褐斑120例[J].中国中医药现代远程教育,2008,6(4):364.
[15]陈希锋,蓝天飞,李秋芝.腹针结合中药治疗黄褐斑疗效观察[J].时珍国医国药,2008,19(2):477.
[16]田博文.埋线配合中药治疗黄褐斑临床观察[J].针灸临床杂志,2008,24(10):17-18.
[17]金玉,蒋文波,傅海扬,等.穴位注射联合水光注射治疗黄褐斑47例[J].中国针灸,2017,37(11):1212-1214.
[18]史红斐,徐兵,郭希超,等.调肝脾针法治疗黄褐斑的疗效及女性激素、促黑激素、超氧化物歧化酶、过氧化脂质的观察[J].浙江中医杂志,2009,44(1):52-54.
[19]江百芝.穴位注射合并压迫耳穴治疗黄褐斑[J].河南中医.1997;17(5):306-307.
[20]潘瑜.穴位敷贴配刮痧疗法治疗气滞血瘀型黄褐斑的临床疗效观察[D].广州:广州中医药大学,2012.
[21]刘宁英.复方当归注射液结合围刺法治疗黄褐斑的体会[J].四川中医,2014,36(12):58-59.
[2]中国中西医结合学会皮肤性病专业委员会色素病学组.黄褐斑及白瘫风诊疗标准(2010年版)[J].中华皮肤科杂志,2010(6):343.
[3]王忆勤.中医诊断学[M].北京:中国中医药出版社,2004:163.
[4]李日庆.中医外科学[M].北京:中国中医药出版社,2002:205-207.
[5]赵晓琴.黄褐斑的辨证分型治疗[J].辽宁中医杂志,2002,29(7):444-445.
[6]吴慧金,林光丽,张宏伟.消斑片治疗黄褐斑60例疗效观察[J].新中医,2004,36(1):44-45.
[7]万克英,罗丽芳,于广松.复方活血汤治疗黄褐斑的临床观察及对性激素的影响[J].中国皮肤病学杂志,2004,18(6):368-369.
[8]晏淑梅.中医辨治面部黄褐斑的点滴体会[J].四川中医,2004,22(2):78-79.
[9]林宝珍,陈友义,陈芳,等.中药J105退斑润白面膜治疗黄褐斑60例[J].福建中医药,2004,35(5):30.
[10]刘保国,李志英,李保卫,等.复方杏仁面膜对黄褐斑患者血清SOD,MDA的影响[J].中国实验方剂学杂志,2008,14(9):682-686.
[11]余蕾.针刺加耳穴贴压治疗黄褐斑59例疗效观察[J].中国针灸,2000,20(9):45.
[12]肖平,孙远征,侯慧先.督脉埋针治疗女性黄褐斑的临床研究[J].针灸临床杂志,2005,21(6):21-22.
[13]周永忠.穴位注射加局部围刺治疗黄褐斑46例[J].中国针灸,2007,27(S1):50.
[14]刘文国.刮瘩、刺血拔罐治疗面部黄褐斑120例[J].中国中医药现代远程教育,2008,6(4):364.
[15]陈希锋,蓝天飞,李秋芝.腹针结合中药治疗黄褐斑疗效观察[J].时珍国医国药,2008,19(2):477.
[16]田博文.埋线配合中药治疗黄褐斑临床观察[J].针灸临床杂志,2008,24(10):17-18.
[17]金玉,蒋文波,傅海扬,等.穴位注射联合水光注射治疗黄褐斑47例[J].中国针灸,2017,37(11):1212-1214.
[18]史红斐,徐兵,郭希超,等.调肝脾针法治疗黄褐斑的疗效及女性激素、促黑激素、超氧化物歧化酶、过氧化脂质的观察[J].浙江中医杂志,2009,44(1):52-54.
[19]江百芝.穴位注射合并压迫耳穴治疗黄褐斑[J].河南中医.1997;17(5):306-307.
[20]潘瑜.穴位敷贴配刮痧疗法治疗气滞血瘀型黄褐斑的临床疗效观察[D].广州:广州中医药大学,2012.
[21]刘宁英.复方当归注射液结合围刺法治疗黄褐斑的体会[J].四川中医,2014,36(12):58-59.