幽门螺杆菌感染与细胞自噬的研究进展
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摘要
幽门螺杆菌(Helicobacter pylori,H. pylori)是一种革兰阴性微需氧病原菌,也是定植于人类胃黏膜上皮中最特异的一种致病菌。它与人消化性溃疡、慢性胃炎、胃癌及胃黏膜相关组织淋巴瘤(MALT)等疾病密切相关。此后又发现H. pylori可能是一种兼性胞内菌,该菌可能通过自噬在胃上皮细胞和巨噬细胞中得以生存、繁殖并引起慢性持续性感染。本文根据近年发表的自噬相关文献,对H. pylori感染不同细胞后自噬对其存活的影响以及H. pylori不同配体引起的自噬调节作一综述。
Helicobacter pylori(H. pylori) is a Gram-negative, microaerophilic, prokaryotic microorganism and is the most specific bacteria that colonizes the epithelium of human gastric mucosa. It is involved in the occurrence of various diseases in human stomach. In recent years, it has been found that H. pylori may be a facultative intracellular bacterium that can survive in gastric epithelial cells and macrophages by autophagy and cause chronic persistent infection. This review discussed the effects of autophagy on the survival of H. pylori and the regulation of autophagy induced by different ligands of H. pylori.
Helicobacter pylori(H. pylori) is a Gram-negative, microaerophilic, prokaryotic microorganism and is the most specific bacteria that colonizes the epithelium of human gastric mucosa. It is involved in the occurrence of various diseases in human stomach. In recent years, it has been found that H. pylori may be a facultative intracellular bacterium that can survive in gastric epithelial cells and macrophages by autophagy and cause chronic persistent infection. This review discussed the effects of autophagy on the survival of H. pylori and the regulation of autophagy induced by different ligands of H. pylori.
引文
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[26] Raju D, Hussey S, Ang M, et al. Vacuolating cytotoxin and variants in Atg16L1 that disrupt autophagy promote Helicobacter pylori infection in humans[J]. Gastroenterology, 2012, 142(5): 1160-1171.
[27] Zhu P, Xue J, Zhang ZJ, et al. Helicobacter pylori VacA induces autophagic cell death in gastric epithelial cells via the endoplasmic reticulum stress pathway[J]. Cell Death Dis, 2017, 8(12): 3207.
[28] Halder P, Datta C, Kumar R, et al. The secreted antigen, HP0175, of Helicobacter pylori links the unfolded protein response(UPR) to autophagy in gastric epithelial cells[J]. Cell Microbiol, 2015, 17(5): 714-729.
[29] Zhu H, Wu H, Liu X, et al. Regulation of autophagy by a beclin 1-targeted microRNA, miR-30a, in cancer cells[J]. Autophagy, 2009, 5(6): 816-823.
[30] Zou Z, Wu L, Ding H, et al. MicroRNA-30a sensitizes tumor cells to cis-platinum via suppressing beclin 1-mediated autophagy[J]. J Biol Chem, 2012, 287(6): 4148-4156.
[31] Yang XJ, Si RH, Liang YH, et al. Mir-30d increases intracellular survival of Helicobacter pylori through inhibition of autophagy pathway[J]. World J Gastroenterol, 2016, 22(15): 3978-3991.
[32] Rittig MG, Shaw B, Letley DP, et al. Helicobacter pylori-induced homotypic phagosome fusion in human monocytes is independent of the bacterial vacA and cag status[J]. Cell Microbiol, 2003, 5(12): 887-899.
[33] Wang YH, Wu JJ, Lei HY. The autophagic induction in Helicobacter pylori-infected macrophage[J]. Exp Biol Med(Maywood), 2009, 234(2): 171-180.
[34] Deen NS, Gong L, Naderer T, et al. Analysis of the relative contribution of phagocytosis, LC3-associated phagocytosis, and canonical autophagy during Helicobacter pylori infection of macrophages[J]. Helicobacter, 2015, 20(6): 449-459.
[35] Irving AT, Mimuro H, Kufer TA, et al. The immune receptor NOD1 and kinase RIP2 interact with bacterial peptidoglycan on early endosomes to promote autophagy and inflammatory signaling[J]. Cell Host Microbe, 2014, 15(5): 623-635.
[36] Travassos LH, Carneiro LA, Ramjeet M, et al. Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry[J]. Nat Immunol, 2010, 11(1): 55-62.
[37] 叶丽娜, 谷海瀛. 幽门螺杆菌鞭毛致病机制[J]. 中国老年学杂志, 2015, 35(10): 2855-2859.
[2] De Duve C, Pressman BC, Gianetto R, et al. Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue[J]. Biochem J, 1955, 60(4): 604-617.
[3] Novikoff AB, Beaufay H, DE Duve C. Electron microscopy of lysosomerich fractions from rat liver[J]. J Biophys Biochem Cytol, 1956, 2(Suppl 4): 179-184.
[4] Ashford TP, Porter KR. Cytoplasmic components in hepatic cell lysosomes[J]. J Cell Biol, 1962, 12: 198-202.
[5] Klionsky DJ. Autophagy revisited: A conversation with Christian de Duve[J]. Autophagy, 2008, 4(6): 740-743.
[6] Li X, Prescott M, Adler B, et al. Beclin 1 is required for starvation-enhanced, but not rapamycin-enhanced, LC3-associated phagocytosis of Burkholderia pseudomallei in RAW 264. 7 cells[J]. Infect Immun, 2013, 81(1): 271-277.
[7] Levine B, Mizushima N, Virgin H W. Autophagy in immunity and inflammation[J]. Nature, 2011, 469(7330): 323-335.
[8] Yen WL, Shintani T, Nair U, et al. The conserved oligomeric Golgi complex is involved in double-membrane vesicle formation during autophagy[J]. J Cell Biol, 2010, 188(1): 101-114.
[9] Hailey DW, Kim PK, Satpute-Krishnan P, et al. Mitochondria supply membranes for autophagosome biogenesis during starvation[J]. Cell, 2010, 141(4): 656-667.
[10] Ravikumar B, Moreau K, Jahreiss L, et al. Plasma membrane contributes to the formation of pre-autophagosomal structures[J]. Nat Cell Biol, 2010, 12(8): 747-757.
[11] Scortti M, Monzó HJ, Lacharme-Lora L, et al. The PrfA virulence regulon[J]. Microbes Infect, 2007, 9(10): 1196-1207.
[12] Goldfine H, Wadsworth SJ. Macrophage intracellular signaling induced by Listeria monocytogenes[J]. Microbes Infect, 2002, 4(13): 1335-1343.
[13] Blocker A, Gounon P, Larquet E, et al. The tripartite type III secreton of Shigella flexneri inserts IpaB and IpaC into host membranes[J]. J Cell Biol, 1999, 147(3): 683-693.
[14] Abdallah AM, Gey van Pittius NC, Champion PA, et al. Type VII secretion--mycobacteria show the way[J]. Nat Rev Microbiol, 2007, 5(11): 883-891.
[15] Brumell JH, Grinstein S. Salmonella redirects phagosomal maturation[J]. Curr Opin Microbiol, 2004, 7(1): 78-84.
[16] van der Wel N, Hava D, Houben D, et al. M. tuberculosis and M. leprae translocate from the phagolysosome to the cytosol in myeloid cells[J]. Cell, 2007, 129(7): 1287-1298.
[17] Romano PS, Gutierrez MG, Berón W, et al. The autophagic pathway is actively modulated by phase II Coxiella burnetii to efficiently replicate in the host cell[J]. Cell Microbiol, 2007, 9(4): 891-909.
[18] Tang B, Li N, Gu J, et al. Compromised autophagy by MIR30B benefits the intracellular survival of Helicobacter pylori[J]. Autophagy, 2012, 8(7): 1045-1057.
[19] ZHANG Jinling, LUO Wei, GU Haiyin. The isolation and identification of Helicobacter pylori flagella and its effect on macrophage autophagy function[J]. Immunol J, 2016, 32(10): 917-920. (in Chinese) 张晋玲, 罗微, 谷海瀛. 幽门螺杆菌鞭毛的分离鉴定及对巨噬细胞自噬功能影响的初步研究[J]. 免疫学杂志, 2016, 32(10): 917-920.
[20] Terebiznik MR, Raju D, Vázquez CL, et al. Effect of Helicobacter pylori′s vacuolating cytotoxin on the autophagy pathway in gastric epithelial cells[J]. Autophagy, 2009, 5(3): 370-379.
[21] Zhang L, Hu W, Cho CH, et al. Reduced lysosomal clearance of autophagosomes promotes survival and colonization of Helicobacter pylori[J]. J Pathol, 2018, 244(4): 432-444.
[22] Tanaka S, Nagashima H, Uotani T, et al. Autophagy-related genes in Helicobacter pylori infection[J]. Helicobacter, 2017, 22(3). doi: 10. 1111/hel. 12376.
[23] Wroblewski LE, Peek RJ, Wilson KT. Helicobacter pylori and gastric cancer: Factors that modulate disease risk[J]. Clin Microbiol Rev, 2010, 23(4): 713-739.
[24] Wen S, Moss SF. Helicobacter pylori virulence factors in gastric carcinogenesis[J]. Cancer Lett, 2009, 282(1): 1-8.
[25] BI Yue, LUO Wei, GU Haiying. An overview of mechanism on Helicobacter pylori pathogenic factors[J]. Basic Clin Med, 2018, 38(5): 713-716. (in Chinese) 毕月, 罗微, 谷海瀛. 幽门螺杆菌致病因子作用机制研究概述[J]. 基础医学与临床, 38(5): 713-716.
[26] Raju D, Hussey S, Ang M, et al. Vacuolating cytotoxin and variants in Atg16L1 that disrupt autophagy promote Helicobacter pylori infection in humans[J]. Gastroenterology, 2012, 142(5): 1160-1171.
[27] Zhu P, Xue J, Zhang ZJ, et al. Helicobacter pylori VacA induces autophagic cell death in gastric epithelial cells via the endoplasmic reticulum stress pathway[J]. Cell Death Dis, 2017, 8(12): 3207.
[28] Halder P, Datta C, Kumar R, et al. The secreted antigen, HP0175, of Helicobacter pylori links the unfolded protein response(UPR) to autophagy in gastric epithelial cells[J]. Cell Microbiol, 2015, 17(5): 714-729.
[29] Zhu H, Wu H, Liu X, et al. Regulation of autophagy by a beclin 1-targeted microRNA, miR-30a, in cancer cells[J]. Autophagy, 2009, 5(6): 816-823.
[30] Zou Z, Wu L, Ding H, et al. MicroRNA-30a sensitizes tumor cells to cis-platinum via suppressing beclin 1-mediated autophagy[J]. J Biol Chem, 2012, 287(6): 4148-4156.
[31] Yang XJ, Si RH, Liang YH, et al. Mir-30d increases intracellular survival of Helicobacter pylori through inhibition of autophagy pathway[J]. World J Gastroenterol, 2016, 22(15): 3978-3991.
[32] Rittig MG, Shaw B, Letley DP, et al. Helicobacter pylori-induced homotypic phagosome fusion in human monocytes is independent of the bacterial vacA and cag status[J]. Cell Microbiol, 2003, 5(12): 887-899.
[33] Wang YH, Wu JJ, Lei HY. The autophagic induction in Helicobacter pylori-infected macrophage[J]. Exp Biol Med(Maywood), 2009, 234(2): 171-180.
[34] Deen NS, Gong L, Naderer T, et al. Analysis of the relative contribution of phagocytosis, LC3-associated phagocytosis, and canonical autophagy during Helicobacter pylori infection of macrophages[J]. Helicobacter, 2015, 20(6): 449-459.
[35] Irving AT, Mimuro H, Kufer TA, et al. The immune receptor NOD1 and kinase RIP2 interact with bacterial peptidoglycan on early endosomes to promote autophagy and inflammatory signaling[J]. Cell Host Microbe, 2014, 15(5): 623-635.
[36] Travassos LH, Carneiro LA, Ramjeet M, et al. Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry[J]. Nat Immunol, 2010, 11(1): 55-62.
[37] 叶丽娜, 谷海瀛. 幽门螺杆菌鞭毛致病机制[J]. 中国老年学杂志, 2015, 35(10): 2855-2859.