盐酸氨溴索雾化吸入疗法治疗老年慢性支气管炎的疗效
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摘要
目的分析老年慢性支气管炎应用盐酸氨溴索雾化吸入治疗的效果。方法选取2017年1月至2018年1月在本院诊治的128例慢性支气管老年患者临床资料,按不同治疗方案分为两组,每组64例,对照组行常规疗法,观察组在常规疗法基础雾化吸入盐酸氨溴索治疗,比较两组疗效及炎症水平、血气指标。结果观察组治疗总有效率95.31%比对照组79.69%高(P<0.01);观察组治疗后TNF-α(1.63±0.47)μg/ml、IL-6(57.96±6.67)pg/L、IL-8(128.53±3.21)ng/L均比对照组低(P<0.01);观察组治疗后PaCO2(36.14±1.96)mmHg比对照组低,PaO2(85.36±11.36)mmHg、CaO2(8.96±1.47)mmol/L均比对照组高(P<0.01)。结论慢性支气管炎老年患者应用盐酸氨溴索雾化吸入治疗能有效缓解症状,减轻炎症反应,改善血气指标,提高临床疗效。
Objective To analyze the efficacy of atomized inhalation of ambroxol hydrochloride in the treatment of senile chronic bronchitis.Methods The clinical data of 128 cases of chronic bronchial elderly patients diagnosed and treated in our hospital from January 2017 to January2018 were selected and divided into two groups according to different treatment schemes, 64 cases in each group. The control group was treated with conventional therapy. The observation group was treated with atomized inhaled saline ambroxol on the basis of conventional therapy, and the efficacy, inflammatory level and blood gas indexes of the two groups were compared. Results The total effective rate of treatment in the observation group was 95.31% higher than that in the control group(79.69%)(P<0.01). The observation group after treatment TNF alpha(1.63±0.47)μg/ml, IL-6(57.96±6.67)pg/L, IL-8(128.53±3.21)ng/L are lower than the control group(P<0.01); After treatment, PaCO2(36.14±1.96)mmHg in the observation group was lower than that in the control group, while PaO2(85.36±11.36)mmHg and CaO2(8.96±1.47)mmol/L were higher than that in the control group(P<0.01). Conclusion Atomization inhalation of ambroxol hydrochloride can effectively relieve symptoms, reduce inflammation, improve blood gas index and improve clinical efficacy in elderly patients with chronic bronchitis.
Objective To analyze the efficacy of atomized inhalation of ambroxol hydrochloride in the treatment of senile chronic bronchitis.Methods The clinical data of 128 cases of chronic bronchial elderly patients diagnosed and treated in our hospital from January 2017 to January2018 were selected and divided into two groups according to different treatment schemes, 64 cases in each group. The control group was treated with conventional therapy. The observation group was treated with atomized inhaled saline ambroxol on the basis of conventional therapy, and the efficacy, inflammatory level and blood gas indexes of the two groups were compared. Results The total effective rate of treatment in the observation group was 95.31% higher than that in the control group(79.69%)(P<0.01). The observation group after treatment TNF alpha(1.63±0.47)μg/ml, IL-6(57.96±6.67)pg/L, IL-8(128.53±3.21)ng/L are lower than the control group(P<0.01); After treatment, PaCO2(36.14±1.96)mmHg in the observation group was lower than that in the control group, while PaO2(85.36±11.36)mmHg and CaO2(8.96±1.47)mmol/L were higher than that in the control group(P<0.01). Conclusion Atomization inhalation of ambroxol hydrochloride can effectively relieve symptoms, reduce inflammation, improve blood gas index and improve clinical efficacy in elderly patients with chronic bronchitis.
引文
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[8]邢爱民,高静珍,刘淑芹.盐酸氨溴索联合复方异丙托溴铵在老年人难治性肺炎中的应用价值[J].中华老年医学杂志,2016,35(8):854-857.
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[2]尚茜,商伟娜,翟琳,等.重症肺部感染患者盐酸氨溴索气管镜灌洗对肺功能水平的影响研究[J].中华医院感染学杂志,2015,25(15):3470-3472.
[3]陈灏珠,林果为,王吉耀.实用内科学[M].北京:人民卫生出版社,2013:1-2928.
[4]林琳,王奇,李素云,等.克咳片治疗慢性支气管炎的多中心随机对照临床研究[J].中华中医药杂志,2015,(7):2636-2638.
[5]丁晓英,李强,吴雪燕.中西医结合治疗单纯型慢性支气管炎急性发作期的临床研究[J].中华中医药学刊,2015,(12):3033-3035.
[6]陈春玲.老年慢性支气管炎盐酸氨溴索雾化吸入疗法分析[J].中国医药科学,2017,7(8):228-230.
[7]付国昊.盐酸氨溴索及异丙托溴铵联合布地奈德治疗慢性阻塞性肺疾病急性加重患者的疗效观察[J].中华老年医学杂志,2015,34(9):979-980.
[8]邢爱民,高静珍,刘淑芹.盐酸氨溴索联合复方异丙托溴铵在老年人难治性肺炎中的应用价值[J].中华老年医学杂志,2016,35(8):854-857.
[9]曾国根,肖彩宏,徐海冰.盐酸氨溴索治疗慢性支气管炎急性发作的疗效观察及评估[J].临床医学工程,2017,24(2):193-194.
[10]胡俞新.老年慢性气管炎患者治疗前后血清IL-6、IL-8、IL-10、TNF-0水平变化的临床意义[J].中国医药科学,2015,5(17):139-142.