摘要
目的探讨血清同型半胱氨酸(Hcy)最佳切点选择与孕妇早产的关系,分析Hcy水平对早产儿结局影响。方法选择114例早产孕妇,103例正常产检孕妇为正常对照组,检测其Hcy、D-二聚体及超敏C反应蛋白;运用SPSS 13.0软件分析其ROC曲线,对早产危险因素进行多因素logistic回归分析。结果(1)早产孕妇组Hcy、HS-CRP以及D-二聚体水平高于正常对照组,差异有统计学意义(P<0.05)。(2)Logistic回归分析得出Hcy水平相对危险系数(OR)为9.736,并获得早产概率回归方程。(3)应用ROC曲线评价Hcy在早产的危险因子中预测值0.931;当Hcy为13.8μmol/L时,其Youden指数为0.784。(4)早产孕妇Hcy水平升高会导致发生SGA可能性明显增加。结论在预测早产危险因素时,Hcy最佳预测切值是13.8μmol/L,是早产独立危险因素之一。
Objective ine(Hcy)and premature delivery in pregnant women,and to analyze the influence of Hcy levels on the outcome ofpreterm infants.Methods Totally 114 cases of pregnant women were chosen as observation group and 103 cases ofnormal as control group.Hcy,D-D and hypersensitive C reactive protein were detected;analysis of the ROC curvewas conducted by using the SPSS 13 software and the risk factors for preterm delivery were analyzed using logisticmultivariate regression analysis.Results(1)The levels of Hcy,HS-CRP and D-D in preterm pregnant womenwere higher than those in control group and the difference was statistically significant(P < 0.05).(2)Logisticregression analysis showed that the relative risk coefficient(OR)of Hcy was 9.736,and the regression equation ofpremature birth probability was obtained.(3)ROC curve to evaluate the predictive value of Hcy in risk factors ofpreterm birth was 0.931;when Hcy was 13.8 μmol/L,the Youden index was 0.784.(4)Elevated levels of Hcy inpreterm women led to a marked increase in the likelihood of SGA.Conclusion When predicting risk factors forpreterm birth,the best predictive cutoff value for Hcy is 13.8 μmol/L,which is one of the independent risk factorsfor preterm birth.
引文
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