半胱氨酸白三烯、总IgE、呼出气一氧化氮及潮气肺功能预测毛细支气管炎再次喘息的价值
摘要
目的探讨半胱氨酸白三烯(Cys LTs)、总Ig E、皮肤点刺过敏原、呼出气一氧化氮(Fe NO)及潮气肺功能预测毛细支气管炎患儿再次喘息的价值。方法选取2016年11月至2017年2月本院呼吸科住院的毛细支气管炎患儿为研究对象,同期儿童保健科体检的健康婴幼儿作为对照组。随访1年观察研究对象再次喘息的情况。根据再次喘息的情况分为喘息组、未再喘息组。回顾性分析Cys LTs、总Ig E、皮肤点刺过敏原、Fe NO值及潮气肺功能的差异。结果喘息组中Cys LTs水平高于对照组及未喘息组(P <0. 01);总Ig E水平及过敏原阳性率比较差异无统计学意义(P> 0. 05);喘息组住院时间、Fe NO值均高于未再喘息组,达峰时间比(t PTEF/t E)、达峰容积时间比(v PTEF/v E)低于未再喘息组,差异有统计学意义(P <0. 05)。结论 Cys LTs、Fe NO及肺功能的综合分析可能对预测毛细支气管炎的再次喘息有一定意义,指导临床对毛细支气管炎合理的治疗。
引文
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[3]张皓,邬宇芬,黄剑峰,等.儿童肺功能检测及评估专家共识[J].临床儿科杂志,2014,32(2):104-114. DOI:10. 3969/j.issn. 1000-3606. 2014. 02. 002.
[4]Takaku Y,Nakagome K,kobayashi T,et al. Changes In Airway Inflammation And Hyperresponsiveness Following Cessation Of Inhaled Corticosteroid In Asthma[J]. Int Arch Allergy Immunol,2010,152(2):41-46. DOI:10. 1016/j. jaci. 2009. 12. 255.
[5]Bush A. Montelukast in paediatric asthma:where we are now and what still needs to be done?[J]. Paediatr Respir Rev,2015,16(2):97-100. DOI:10. 1016/j. prrv. 2014. 10. 007.
[6]吴华.白三烯及其受体拮抗剂在肺部疾病中作用的研究进展[J/CD].中华妇幼临床医学杂志:电子版,2017,13(2):234-239. DOI:10. 3877/cma. j. issn. 1673-5250. 2017. 02. 022.
[7]Castro-Rodriguez JA,Rodriguez-Martinez CE,Sossa-Brice1o MP.Principal findings of systematic reviews for the management of acute bronchiolitis in children[J]. Paediatr Respir Rev,2015,16(4):267-275. DOI:10. 1016/j. prrv. 2014. 11. 004.
[8]刘雪茹,胡艳,陈和斌,等.孟鲁司特钠治疗儿童呼吸道合胞病毒感染毛细支气管炎的疗效及对炎症标志物的影响[J].中华医院感染学杂志,2018,28(2):276-279. DOI:10. 11816/cn. ni. 2018-171342.
[9]冯伟静,张爱华,张荣荣,等.毛细支气管炎患儿血清维生素D及免疫球蛋白水平的意义[J].中华实用儿科临床杂志,2014,29(24):1919-1920. DOI:10. 3760/cma. j. issn. 2095-428X. 2014. 24. 023.
[10]Oh JW,Shin SA,Lee HB. Urine leukotriene E and eosinophil cationic protein in nasopharyngeal aspiration from young wheezy children[J]. Pediatr Allergy Immunol,2005,16(5):416-421.DOI:10. 1111/j. 1399-3038. 2005. 00294. x.
[11]孔灵菲.最新全球哮喘防治指南解读[J].中国实用内科杂志,2007,27(4):255-257. DOI:10. 3969/j. issn. 1005-2194.2007. 04. 007.
[12]Liu C,Zheng M,He F,et al. Role of exhaled nasal nitric oxide in distinguishing between chronic rhinosinusitis with and without nasal polyps[J]. Am J Rhinol Allergy,2017,31(6):389-394.DOI:10. 2500/ajra. 2017. 31. 4480.
[13]Konstantinou GN,Xepapadaki P,Manousakis E,et al. Assessment of airflow limitation,airway inflammation,and symptoms during virus-induced wheezing episodes in 4-to 6-year-old children[J]. J Allergy Clin Immunol,2013,131(1):87-93. e1-5. DOI:10. 1016/j. jaci. 2012. 10. 033.
[14]韩文,谢勇,任淑颖,等.潮气呼吸肺功能检测在1~4岁儿童喘息性疾病中的临床应用[J].中国当代儿科杂志,2014,16(8):800-804. DOI:10. 7499/j. issn. 1008-8830. 2014. 08. 006.
[15]Mc Evoy CT,Schilling D,Clay N,et al. Vitamin C supplementation for pregnant smoking women and pulmonary function in their newborn infants:a randomized clinical trial[J]. JAMA,2014,311(20):2074-2082. DOI:10. 1001/jama. 2014. 5217.