不同分型自身免疫性肝炎患者谷草转氨酶线粒体同工酶及谷草转氨酶水平变化及意义
|
摘要
目的探讨谷草转氨酶线粒体同工酶(mitochondrial glutamic-oxaloacetic transaminase,m-GOT)及谷草转氨酶(glutamic-oxaloacetic transaminase,GOT)在不同分型自身免疫性肝炎患者中的水平变化及意义。方法自身免疫性肝炎患者196例(观察组),其中Ⅰ型患者137例(Ⅰ型组),Ⅱ型患者24例(Ⅱ型组),Ⅲ型患者35例(Ⅲ型组),同期体检健康252例为对照组,检测各组血清m-GOT、GOT水平,并进行比较。结果观察组血清m-GOT、GOT[(40.75±23.32)、(100.20±60.38)u/L]水平均高于对照组[(16.31±5.11)、(20.97±4.76)u/L](P<0.05);Ⅰ型组血清m-GOT、GOT[(63.85±13.98)、(135.60±30.72)u/L]水平高于Ⅱ型组[(30.88±7.18)、(81.32±21.87)u/L]、Ⅲ型组[(28.32±9.03)、(83.67±20.55)u/L](P<0.05);Ⅱ、Ⅲ型组血清m-GOT、GOT水平比较差异无统计学意义(P>0.05)。结论自身免疫性肝炎患者尤其是Ⅰ型患者肝细胞损伤严重,血清GOT、m-GOT水平增高,检测血清GOT、m-GOT水平有助于自身免疫性肝炎诊断,对其分型诊断也有一定价值。
Objective To explore the changes and significances of mitochondrial glutamic-oxaloacetic transaminase(m-GOT)and glutamic-oxaloacetic transaminase(GOT)in patients with different types of autoimmune hepatitis.Methods The levels of m-GOT and GOT were detected and compared in 196 patients with autoimmune hepatitis(observation group)including 137 patients with typeⅠ(typeⅠ group),24 patients with typeⅡ(typeⅡ group)and35 patients with type Ⅲ(type Ⅲ group),as well as in another 252 healthy volunteers(control group).Results The levels of serum m-GOT and GOT were significantly higher in observation group((40.75±23.32),(100.20±60.38)u/L)than those in control group((16.31±5.11),(20.97±4.76)u/L)(P<0.05),and in type Ⅰ group((63.85±13.98),(135.6±30.72)u/L)than those in typeⅡ group((30.88±7.18),(81.32±21.87)u/L)and typeⅢ group((28.32±9.03),(83.67±20.55)u/L)(P<0.05),and three were no significant differences between typeⅡgroup and typeⅢ group(P>0.05).Conclusion The hepatic cells are severely injured and the levels of serum GOT and m-GOT increase in patients with autoimmune hepatitis,especially in patients with autoimmune hepatitis type Ⅰ.The detection of serum GOT and m-GOT contributes to the diagnosis and classification of autoimmune hepatitis.
Objective To explore the changes and significances of mitochondrial glutamic-oxaloacetic transaminase(m-GOT)and glutamic-oxaloacetic transaminase(GOT)in patients with different types of autoimmune hepatitis.Methods The levels of m-GOT and GOT were detected and compared in 196 patients with autoimmune hepatitis(observation group)including 137 patients with typeⅠ(typeⅠ group),24 patients with typeⅡ(typeⅡ group)and35 patients with type Ⅲ(type Ⅲ group),as well as in another 252 healthy volunteers(control group).Results The levels of serum m-GOT and GOT were significantly higher in observation group((40.75±23.32),(100.20±60.38)u/L)than those in control group((16.31±5.11),(20.97±4.76)u/L)(P<0.05),and in type Ⅰ group((63.85±13.98),(135.6±30.72)u/L)than those in typeⅡ group((30.88±7.18),(81.32±21.87)u/L)and typeⅢ group((28.32±9.03),(83.67±20.55)u/L)(P<0.05),and three were no significant differences between typeⅡgroup and typeⅢ group(P>0.05).Conclusion The hepatic cells are severely injured and the levels of serum GOT and m-GOT increase in patients with autoimmune hepatitis,especially in patients with autoimmune hepatitis type Ⅰ.The detection of serum GOT and m-GOT contributes to the diagnosis and classification of autoimmune hepatitis.
引文
[1]中华医学会肝病学分会.自身免疫性肝炎诊断和治疗共识(2015)[J].中华肝脏病杂志,2016,21(1):165-178.
[2]孙颖,滕光菊,常彬霞,等.自身免疫性肝炎采用免疫抑制剂治疗的疗效预测[J].肝脏,2012,17(11):803-807.
[3]高燕,张永良,沈喜.天冬氨酸氨基转移酶线粒体同工酶测定临床意义[J].实用医技杂志,2007,14(7):853-854.
[4]赵丹彤,闫惠平.自身免疫性肝病抗原抗体研究及临床意义[J].传染病信息,2018,31(2):97-100.
[5]王倩怡,贾继东.自身免疫性肝炎发病机制研究进展[J].临床肝胆病杂志,2011,27(6):572-576.
[6]于晓华,刘国强.自身免疫性肝病患者相关自身抗体的检测分析[J].中国医药指南,2017,15(3):27-28.
[7]杨美荣,刘斌,张国顺.双环醇联合异甘草酸镁治疗药物诱导自身免疫性肝炎效果观察[J].中华实用诊断与治疗杂志,2017,31(3):278-280.
[2]孙颖,滕光菊,常彬霞,等.自身免疫性肝炎采用免疫抑制剂治疗的疗效预测[J].肝脏,2012,17(11):803-807.
[3]高燕,张永良,沈喜.天冬氨酸氨基转移酶线粒体同工酶测定临床意义[J].实用医技杂志,2007,14(7):853-854.
[4]赵丹彤,闫惠平.自身免疫性肝病抗原抗体研究及临床意义[J].传染病信息,2018,31(2):97-100.
[5]王倩怡,贾继东.自身免疫性肝炎发病机制研究进展[J].临床肝胆病杂志,2011,27(6):572-576.
[6]于晓华,刘国强.自身免疫性肝病患者相关自身抗体的检测分析[J].中国医药指南,2017,15(3):27-28.
[7]杨美荣,刘斌,张国顺.双环醇联合异甘草酸镁治疗药物诱导自身免疫性肝炎效果观察[J].中华实用诊断与治疗杂志,2017,31(3):278-280.