兽用二氨基嘧啶类抗菌增效剂毒理学研究进展
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摘要
二氨基嘧啶类抗菌增效剂是一类广谱、高效的药物,广泛应用于临床。综述二氨基嘧啶类抗菌增效剂的毒性作用,主要包括急性毒性、长期毒性、遗传毒性等,以期为评价其安全性,指导临床合理使用,开发新药,避免应用危害提供参考。
Diaminopyrimidine antibacterial synergist is a kind of high-efficiency,low-toxic drug,widely used in clinical practice. This paper reviews the toxicity of diaminopyrimidine antimicrobial synergists,mainly including acute toxicity,long-term toxicity and genetic toxicity,in order to provide a reference for evaluating their safety,guiding clinical rational use,developing new drugs and avoiding the harm of their application.
Diaminopyrimidine antibacterial synergist is a kind of high-efficiency,low-toxic drug,widely used in clinical practice. This paper reviews the toxicity of diaminopyrimidine antimicrobial synergists,mainly including acute toxicity,long-term toxicity and genetic toxicity,in order to provide a reference for evaluating their safety,guiding clinical rational use,developing new drugs and avoiding the harm of their application.
引文
[1]赵蕊,张晓乐.抗菌增效剂临床应用进展[J].临床药物治疗杂志,2003,1(3):35-39.Zhao R,Zhang X L.Progress in clinical application of antibacterial synergists[J].Clinical Medication Journal,2003,1(3):35-39.
[2]孙国祥.新型抗菌增效剂巴喹普林[J].北方牧业,2009,(22):27.Sun G X.A new antibacterial synergist baquiprilin[J].Northern Animal Husbandry,2009,(22):27.
[3]薛凤梅.兽用抗菌增效剂[J].现代畜牧科技,2011,5(5):235.Xue F M.Antibacterial Synergist for Veterinary Use[J].Technical Advisor for Animal Husbandry,2011,5(5):235.
[4]Bushby SRM,Hitchings G H.Trimethoprim,A Sulphonamide Potentiator[J].British Journal of Pharmacology,2012,33(1):72-90.
[5]EMEA(1997)Trimethoprim.Summary Report(2)(EMEA/MRL/255/97-FINAL),London,UK,European Agency for the Evaluation of Medicinal Products,available[June 2005].
[6]Ono T,Sekiya T,Takahashi Y,et al.The genotoxicity of diaveridine and trimethoprim[J].Environmental toxicology and pharmacology,1997,3(4):297.
[7]Abou-Eisha A.Evaluation of cytogenetic and DNA damage induced by the antibacterial drug,trimethoprim[J].Toxicology in Vitro An International Journal Published in Association with Bibra,2006,20(5):601-607.
[8]Binelli A,Cogni D,Parolini M,et al.Cytotoxic and genotoxic effects of in vitro exposure to triclosan and trimethoprim on zebra mussel(Dreissena polymorpha)hemocytes[J].Comparative Biochemistry&Physiology Part C Toxicology&Pharmacology,2009,150(1):50-56.
[9]Papis E,Davies S J,Jha A N.Relative sensitivity of fish and mammalian cells to the antibiotic,trimethoprim:cytotoxic and genotoxic responses as determined by neutral red retention,Comet and micronucleus assays[J].Ecotoxicology,2011,20(1):208-217.
[10]Schulz R.Distribution and elimination of trimethoprim in pregnant and newborn rats[J].Naunyn-Schmiedeberg's Archives of Pharmacology,1972,272(4):369-377.
[11]苏士佳.二甲氧苄啶对Wistar大鼠的毒理学研究[D].武汉:华中农业大学,2011.Su S J.Toxicology of Diaveridine in Wistar rats[D].Wuhan:Huazhong Agricultural University,2011.
[12]Wang J,Sun F,Tang S,et al.Acute,mutagenicity,teratogenicity and subchronic oral toxicity studies of diaveridine in rodents[J].Environmental toxicology and pharmacology,2015,40(2):660-670.
[13]文丽华.二甲氧苄啶在猪、鸡和大鼠体内的处置研究[D].武汉:华中农业大学,2013.Wen L H.The disposition of diaveridine in swine,broilers and rats[D].Wuhan:Huazhong Agricultural University,2013.
[14]Wang X,Su S,Ihsan A,et al.Acute and sub-chronic toxicity study of diaveridine in Wistar rats[J].Regulatory toxicology and pharmacology:RTP,2015,73(1):232-240.
[15]Yoshimura H,.Mutagenicity of the coccidiostat diaveridine in the Salmonella/mammalian microsome assay[J].Mutation research,1991,261(2):149.
[16]Hoffmann-La Roche Inc 1983,Environmental impact analysis report,website:http://www.fda.gov/cvm/FOI/040-209EA.pdf.
[17]Ono T,Sekiya T,Takahashi Y,et al.The genotoxicity of diaveridine and trimethoprim[J].Environmental toxicology and pharmacology,1997,3(4):297-306.
[18]Ono-Ogata T,Ogino T,Nishikawa M,et al.Mutagenic activity and mutational specificity of antiprotozoal drugs with and without nitrite treatment[J].Environmental&Molecular Mutagenesis,2010,39(1):43-48.
[19]Wang X,Tan Z,Cheng G,et al.Two‐generation reproduction and teratology studies of feeding aditoprim in Wistar rats[J].Food&Chemical Toxicology,2015,4(4):956-965.
[20]EMEA(1997)Baquiloprim.Summary Report(2)(EMEA/MRL/199/97-FINAL),London,UK,European Agency for the Evaluation of Medicinal Products,Available[March 2004].
[21]Papich M G.Ormetoprim+Sulfadimethoxine[J].Saunders Handbook of Veterinary Drugs,2016,583-585.
[22]Davami A,Peterson R A,Jones W T,et al.Compatibility of sulfadimethoxine and ormetoprim with lasalocid and monensin on performance of male broiler chickens[J].Poult Sci,1987,66(2):373-375.
[23]Maestrone G,Thompson E,Yeisley H,et al.Prophylactic and therapeutic activity of Rofenaid-40A in an experimental Escherichia coli airsac infection in chickens.[J].Avian Diseases,1979,23(3):682-687.
[24]Then R L,Keller M.Properties of Aditoprim,a New Antibacterial Dihydrofolate Reductase Inhibitor[J].Zentralbl Veterinarmed B,2010,35(110):114-120.
[25]Wolfe G W,Quander R,Kiorpes A,et al.Subchronic toxicity studies of aditoprim in beagle dogs[M].Toxicology,1993:313.
[26]Wang X,Tan Z,Pan Y,et al.Safety assessment of aditoprim acute,subchronic toxicity and mutagenicity studies[J].Journal of Applied Toxicology Jat,2015,35(11):1415-1426.
[2]孙国祥.新型抗菌增效剂巴喹普林[J].北方牧业,2009,(22):27.Sun G X.A new antibacterial synergist baquiprilin[J].Northern Animal Husbandry,2009,(22):27.
[3]薛凤梅.兽用抗菌增效剂[J].现代畜牧科技,2011,5(5):235.Xue F M.Antibacterial Synergist for Veterinary Use[J].Technical Advisor for Animal Husbandry,2011,5(5):235.
[4]Bushby SRM,Hitchings G H.Trimethoprim,A Sulphonamide Potentiator[J].British Journal of Pharmacology,2012,33(1):72-90.
[5]EMEA(1997)Trimethoprim.Summary Report(2)(EMEA/MRL/255/97-FINAL),London,UK,European Agency for the Evaluation of Medicinal Products,available[June 2005].
[6]Ono T,Sekiya T,Takahashi Y,et al.The genotoxicity of diaveridine and trimethoprim[J].Environmental toxicology and pharmacology,1997,3(4):297.
[7]Abou-Eisha A.Evaluation of cytogenetic and DNA damage induced by the antibacterial drug,trimethoprim[J].Toxicology in Vitro An International Journal Published in Association with Bibra,2006,20(5):601-607.
[8]Binelli A,Cogni D,Parolini M,et al.Cytotoxic and genotoxic effects of in vitro exposure to triclosan and trimethoprim on zebra mussel(Dreissena polymorpha)hemocytes[J].Comparative Biochemistry&Physiology Part C Toxicology&Pharmacology,2009,150(1):50-56.
[9]Papis E,Davies S J,Jha A N.Relative sensitivity of fish and mammalian cells to the antibiotic,trimethoprim:cytotoxic and genotoxic responses as determined by neutral red retention,Comet and micronucleus assays[J].Ecotoxicology,2011,20(1):208-217.
[10]Schulz R.Distribution and elimination of trimethoprim in pregnant and newborn rats[J].Naunyn-Schmiedeberg's Archives of Pharmacology,1972,272(4):369-377.
[11]苏士佳.二甲氧苄啶对Wistar大鼠的毒理学研究[D].武汉:华中农业大学,2011.Su S J.Toxicology of Diaveridine in Wistar rats[D].Wuhan:Huazhong Agricultural University,2011.
[12]Wang J,Sun F,Tang S,et al.Acute,mutagenicity,teratogenicity and subchronic oral toxicity studies of diaveridine in rodents[J].Environmental toxicology and pharmacology,2015,40(2):660-670.
[13]文丽华.二甲氧苄啶在猪、鸡和大鼠体内的处置研究[D].武汉:华中农业大学,2013.Wen L H.The disposition of diaveridine in swine,broilers and rats[D].Wuhan:Huazhong Agricultural University,2013.
[14]Wang X,Su S,Ihsan A,et al.Acute and sub-chronic toxicity study of diaveridine in Wistar rats[J].Regulatory toxicology and pharmacology:RTP,2015,73(1):232-240.
[15]Yoshimura H,.Mutagenicity of the coccidiostat diaveridine in the Salmonella/mammalian microsome assay[J].Mutation research,1991,261(2):149.
[16]Hoffmann-La Roche Inc 1983,Environmental impact analysis report,website:http://www.fda.gov/cvm/FOI/040-209EA.pdf.
[17]Ono T,Sekiya T,Takahashi Y,et al.The genotoxicity of diaveridine and trimethoprim[J].Environmental toxicology and pharmacology,1997,3(4):297-306.
[18]Ono-Ogata T,Ogino T,Nishikawa M,et al.Mutagenic activity and mutational specificity of antiprotozoal drugs with and without nitrite treatment[J].Environmental&Molecular Mutagenesis,2010,39(1):43-48.
[19]Wang X,Tan Z,Cheng G,et al.Two‐generation reproduction and teratology studies of feeding aditoprim in Wistar rats[J].Food&Chemical Toxicology,2015,4(4):956-965.
[20]EMEA(1997)Baquiloprim.Summary Report(2)(EMEA/MRL/199/97-FINAL),London,UK,European Agency for the Evaluation of Medicinal Products,Available[March 2004].
[21]Papich M G.Ormetoprim+Sulfadimethoxine[J].Saunders Handbook of Veterinary Drugs,2016,583-585.
[22]Davami A,Peterson R A,Jones W T,et al.Compatibility of sulfadimethoxine and ormetoprim with lasalocid and monensin on performance of male broiler chickens[J].Poult Sci,1987,66(2):373-375.
[23]Maestrone G,Thompson E,Yeisley H,et al.Prophylactic and therapeutic activity of Rofenaid-40A in an experimental Escherichia coli airsac infection in chickens.[J].Avian Diseases,1979,23(3):682-687.
[24]Then R L,Keller M.Properties of Aditoprim,a New Antibacterial Dihydrofolate Reductase Inhibitor[J].Zentralbl Veterinarmed B,2010,35(110):114-120.
[25]Wolfe G W,Quander R,Kiorpes A,et al.Subchronic toxicity studies of aditoprim in beagle dogs[M].Toxicology,1993:313.
[26]Wang X,Tan Z,Pan Y,et al.Safety assessment of aditoprim acute,subchronic toxicity and mutagenicity studies[J].Journal of Applied Toxicology Jat,2015,35(11):1415-1426.