中医治疗黄斑水肿的用药规律
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摘要
目的分析中医治疗黄斑水肿的用药规律。方法计算机检索知网、万方数据库中有关中医药治疗黄斑水肿的文献,筛选出组方明确的方剂。应用中医传承辅助系统软件分析其用药规律。结果共获72首方剂,涉及中药120味。药物性味以甘温为主,主要归肝、脾、心、肾经。使用频次≥10次以上的药物共有25味,其中以茯苓的使用频次最高。演化得出8个核心组合,聚类得到4首新处方。结论治疗黄斑水肿的方剂组方以活血利水为主多用甘温之药。
Objective To analyze the medication rule of macular edema treated by traditional Chinese medicine.Methods A computer-based retrieval was performed in CNKI and Wanfang database for literatures about macular edema treated by traditional Chinese medicine,then the prescriptions with definite formulas were screened out. The medication rule was analyzed using the Traditional Chinese Medicine Inheritance Support System. Results A total of72 prescriptions involving 120 herbs were obtained. The main flavor of the herbs was sweet and warm,and the meridians the herbs involving mostly included liver meridian,spleen meridian,heart meridian and kidney meridian. Of 25 medicines with a frequency of utilization ≥10 times,Poria cocos got the highest frequency. Eight core groups were evolved,then 4 new prescriptions were obtained by clustering. Conclusion The prescriptions for treating macular edema mainly involve in promoting blood circulation and water retention,commonly using the herbs with sweet-warn flavor.
Objective To analyze the medication rule of macular edema treated by traditional Chinese medicine.Methods A computer-based retrieval was performed in CNKI and Wanfang database for literatures about macular edema treated by traditional Chinese medicine,then the prescriptions with definite formulas were screened out. The medication rule was analyzed using the Traditional Chinese Medicine Inheritance Support System. Results A total of72 prescriptions involving 120 herbs were obtained. The main flavor of the herbs was sweet and warm,and the meridians the herbs involving mostly included liver meridian,spleen meridian,heart meridian and kidney meridian. Of 25 medicines with a frequency of utilization ≥10 times,Poria cocos got the highest frequency. Eight core groups were evolved,then 4 new prescriptions were obtained by clustering. Conclusion The prescriptions for treating macular edema mainly involve in promoting blood circulation and water retention,commonly using the herbs with sweet-warn flavor.
引文
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[4]杨安怀,胡焰山,李拓.抗VEGF药物治疗糖尿病性黄斑水肿的疗效与视网膜外丛状层连续性的相关性分析[J].临床眼科杂志,2017,25(5):393-396.
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[6]刘雪霞.眼球后注射曲安奈德联合眼底激光治疗视网膜分支静脉阻塞继发黄斑囊样水肿的疗效观察[J].中华眼科医学杂志(电子版),2014,4(2):73-76.
[7]尚彦霞,王鑫,解世朋,等.玻璃体切除术联合康柏西普治疗增殖型糖尿病视网膜病变合并黄斑水肿的临床疗效观察[J].中国现代医学杂志,2018,28(16):122-124.
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[9]唐仕欢,陈建新,杨洪军,等.基于复杂系统熵聚类方法的中药新药处方发现研究思路[J].世界科学技术-中医药现代化,2009,11(2):225-228.
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[11]游昕,熊大国,郭志斌,等.茯苓多种化学成分及药理作用的研究进展[J].安徽农业科学,2015,43(2):106-109.
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[13]罗旭昇,吴宁玲,郝进.黄斑水肿证治思考[J].中国中医眼科杂志,2013,23(1):49-51.
[14]韦企平.黄斑水肿从痰瘀论治浅谈[J].中国中医眼科杂志,2014,24(3):214-216.
[2]丛玮霞,张仲臣,郝晓琳.糖尿病患者白内障术后黄斑区厚度改变机制的现况研究[J].国际眼科杂志,2017,17(5):888-890.
[3]张风.糖尿病黄斑水肿(DME)治疗进展[J].中国激光医学杂志,2018,27(2):132.
[4]杨安怀,胡焰山,李拓.抗VEGF药物治疗糖尿病性黄斑水肿的疗效与视网膜外丛状层连续性的相关性分析[J].临床眼科杂志,2017,25(5):393-396.
[5]陈懿,陈青山,罗恒,等.微脉冲激光联合抗VEGF药物治疗BRVO继发的黄斑水肿[J].国际眼科杂志,2017,17(6):1 184-1 187.
[6]刘雪霞.眼球后注射曲安奈德联合眼底激光治疗视网膜分支静脉阻塞继发黄斑囊样水肿的疗效观察[J].中华眼科医学杂志(电子版),2014,4(2):73-76.
[7]尚彦霞,王鑫,解世朋,等.玻璃体切除术联合康柏西普治疗增殖型糖尿病视网膜病变合并黄斑水肿的临床疗效观察[J].中国现代医学杂志,2018,28(16):122-124.
[8]高学敏.中药学[M].北京:中国中医药出版社,2002:9.
[9]唐仕欢,陈建新,杨洪军,等.基于复杂系统熵聚类方法的中药新药处方发现研究思路[J].世界科学技术-中医药现代化,2009,11(2):225-228.
[10]陈达夫.中医眼科六经法要[M].成都:四川人民出版社,1978:67.
[11]游昕,熊大国,郭志斌,等.茯苓多种化学成分及药理作用的研究进展[J].安徽农业科学,2015,43(2):106-109.
[12]禹建春,叶红梅,林西西.泽泻的药理研究概况[J].海峡药学,2011,23(2):92-93.
[13]罗旭昇,吴宁玲,郝进.黄斑水肿证治思考[J].中国中医眼科杂志,2013,23(1):49-51.
[14]韦企平.黄斑水肿从痰瘀论治浅谈[J].中国中医眼科杂志,2014,24(3):214-216.