基于甲型流感病毒血凝素的广谱流感疫苗研究进展
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摘要
目前使用的流感疫苗都是针对现行流行株设计的,因此难以有效应对病毒快速变异出现的新病毒株,而开发能同时抵抗多个流感病毒株感染具有交叉保护作用的通用疫苗是今后流感疫苗研发的趋势。本研究对近年来基于流感病毒血凝素构建的通用流感疫苗作一综述。
At present, influenza vaccines are designed for the circulating strains, so it is difficult to effectively respond to new strains due to the rapid variation of influenza virus. The trend of future influenza vaccine development is a universal influenza vaccine that can simultaneously protect against multiple influenza virus strains with cross-protection. The research reviews recent general influenza vaccines based on influenza virus hemagglutinin construction in recent years.
At present, influenza vaccines are designed for the circulating strains, so it is difficult to effectively respond to new strains due to the rapid variation of influenza virus. The trend of future influenza vaccine development is a universal influenza vaccine that can simultaneously protect against multiple influenza virus strains with cross-protection. The research reviews recent general influenza vaccines based on influenza virus hemagglutinin construction in recent years.
引文
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[22]Wang TT,Tan GS,Hai R,et al.Vaccination with a synthetic peptide from theinfluenza virus hemagglutinin provides protection against distinct viral subtypes[J].Proc Natl Acad Sci U S A,2010,107(44):18979-18984.
[23]Krammer F,Pica N,Hai R,et al.Chimeric hemagglutinin influenza virus vaccine constructs elicit broadly protective stalk-specific antibodies[J].J Virol,2013,87(12):6542-6550.
[24]Ramirez A,Morris S,Maucourant S,et al.A virus-like particle vaccine candidate for influenza A virus based on multiple conserved antigens presented on hepatitis B tandem core particles[J].Vaccine,2018,36(6):873-880.
[25]Tamar BY,Marcus H,Reisner Y,et al.Intranasal administration of peptide vaccine protects human/mouse radiation chimera from influenza infection[J].Int Immunol,1999,11(7):1043-1051.
[26]Adar Y,Singer Y,Levi R,et al.A universal epitope-based influenza vaccine and its efficacy against H5N1[J].Vaccine,2009,27(15):2099-2107.
[27]Atsmon J,Caraco Y,Sagit ZS,et al.Priming by a novel universal influenza vaccine(Multimeric-001)-a gateway for improving immune response in the elderly population[J].Vaccine,2014,32(44):5816-5823.
[2]Gerdil C.The annual production cycle for influenza vaccine[J].Vaccine,2003,21(16):1776-1779.
[3]Palese P.Making better influenza virus vaccines[J].Emerg Infect Dis,2006,12(1):61-65.
[4]Valkenburg SA,Mallajosyula VV,Li OT,et al.Stalking influenza by vaccination with pre-fusion headless HA ministem[J].Sci Rep,2016,6:22666.
[5]Gao D,Chen Y,Han D,et al.Membrane-anchored stalk domain of influenza HA enhanced immune responses in mice[J].Microb Pathog,2017,113:421-426.
[6]Horvath A,Toth GK,Gogolak P,et al.A hemagglutininbased multipeptide construct elicits enhanced protective immune response in mice against influenza A virus infection[J].Immunol Lett,1998,60(2/3):127-136.
[7]Li C,Jaentschke B,Song Y,et al.A simple slot blot for the detection of virtually all subtypes of the influenza A viral hemagglutinins using universal antibodies targeting the fusion peptide[J].Nat Protoc,2010,5(1):14-19.
[8]Chun S,Li C,Van Domselaar G,et al.Universal antibodies and their applications to the quantitative determination of virtually all subtypes of the influenza A viral hemagglutinins[J].Vaccine,2008,26(48):6068-6076.
[9]Bianchi E,Liang X,Ingallinella P,et al.Universal influenza B vaccine based on the maturational cleavage site of the hemagglutinin precursor[J].J Virol,2005,79(12):7380-7388.
[10]Ekiert DC,Bhabha G,Elsliger MA,et al.Antibody recognition of a highly conserved influenza virus epitope[J].Science,2009,324(5924):246-251.
[11]Prabhu N,Prabakaran M,Ho HT,et al.Monoclonal antibodies against the fusion peptide of hemagglutinin protect mice from lethal influenza A virus H5N1 infection[J].J Virol,2009,83(6):2553-2562.
[12]Sui J,Hwang WC,Perez S,et al.Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses[J].Nat Struct Mol Biol,2009,16(3):265-273.
[13]Fouchier R.A,Schneeberger PM,Rozendaal FW,et al.Avian influenza A virus(H7N7)associated with human conjunctivitis and a fatal case of acute respiratory distress syndrome[J].Proc Natl Acad Sci U S A,2004,101(5):1356-1361.
[14]Graves PN,Schulman JL,Young JF,et al.Preparation of influenza virus subviral particles lacking the HA1 subunit of hemagglutinin:unmasking of cross-reactive HA2 determinants[J].Virology,1983,126(1):106-116.
[15]Sagawa H,Ohshima A,Kato I,et al.The immunological activity of a deletion mutant of influenza virus haemagglutinin lacking the globular region[J].J Gen Virol,1996,77(Pt7):1483-1487.
[16]Kashyap AK,Steel J,Oner AF,et al.Combinatorial antibody libraries from survivors of the Turkish H5N1 avian influenza outbreak reveal virus neutralization strategies[J].Proc Natl Acad Sci U S A,2008,105(16):5986-5991.
[17]Okuno Y,Isegawa Y,Sasao F,et al.A common neutralizing epitope conserved between the hemagglutinins of influenza A virus H1 and H2 strains[J].J Virol,1993,67(5):2552-2558.
[18]Wrammert J,Koutsonanos D,Li GM,et al.Broadly crossreactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection[J].J Exp Med,2011,8(1):181-193.
[19]Corti D,Voss J,Gamblin SJ,et al.A neutralizing antibody selected from plasma cells that binds to group 1 and group2 influenza A hemagglutinins[J].Science,2011,333(6044):850-856.
[20]Ekiert DC,Friesen RH,Bhabha G,et al.A highly conserved neutralizing epitope on group 2 influenza A viruses[J].Science,2011,333(6044):843-850.
[21]Steel J,Lowen AC,Wang TT,et al.Influenza virus vaccine based on the conserved hemagglutinin stalkdomain[J].M Bio,2010,1(1):1-9.
[22]Wang TT,Tan GS,Hai R,et al.Vaccination with a synthetic peptide from theinfluenza virus hemagglutinin provides protection against distinct viral subtypes[J].Proc Natl Acad Sci U S A,2010,107(44):18979-18984.
[23]Krammer F,Pica N,Hai R,et al.Chimeric hemagglutinin influenza virus vaccine constructs elicit broadly protective stalk-specific antibodies[J].J Virol,2013,87(12):6542-6550.
[24]Ramirez A,Morris S,Maucourant S,et al.A virus-like particle vaccine candidate for influenza A virus based on multiple conserved antigens presented on hepatitis B tandem core particles[J].Vaccine,2018,36(6):873-880.
[25]Tamar BY,Marcus H,Reisner Y,et al.Intranasal administration of peptide vaccine protects human/mouse radiation chimera from influenza infection[J].Int Immunol,1999,11(7):1043-1051.
[26]Adar Y,Singer Y,Levi R,et al.A universal epitope-based influenza vaccine and its efficacy against H5N1[J].Vaccine,2009,27(15):2099-2107.
[27]Atsmon J,Caraco Y,Sagit ZS,et al.Priming by a novel universal influenza vaccine(Multimeric-001)-a gateway for improving immune response in the elderly population[J].Vaccine,2014,32(44):5816-5823.