淋病奈瑟菌对头孢曲松耐药趋势的国内文献综述
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摘要
为了解我国临床淋病奈瑟菌对头孢曲松的耐药趋势,本研究利用中国期刊全文数据库检索公开发表的关于淋病奈瑟菌耐药性监测文献,按一定标准进行筛选、归类,计算和分析不同年份和地区淋病奈瑟菌对头孢曲松的耐药率与敏感率。共筛选文献101篇,数据主要集中在2000~2010年,经分析,全国耐药率:平均为0.66%,2008年最高为1.45%;全国敏感率:平均为68.83%,2001年最低仅56.44%。期间淋病奈瑟菌对头孢曲松的耐药率与敏感率在不同年份、不同地区均呈波动变化。从文献分析结果可知,2000~2010年虽然各地区耐药率有差异,但总体上我国临床分离淋病奈瑟菌对头孢曲松耐药率呈上升趋势,敏感率下降。
To investigate the situation and tendency of ceftriaxone( CRO) resistance to clinical isolations of Neisseria gonorrhoeae( Ng),all the references related to drug resistance of Ng were retrieved through CNKI databank according to certain criteria. The resistance rates and sensibility of different types of bacteria were classified according to regions and years. A total of 101 documents were eventually amd nationally collected from 2000 to 2010. The average resistance rate of Ng to CRO was 0. 66% and the highest one was 1. 45% in 2008. The average sensibility was 68. 83% and the lowest was56. 44% in 2001. In different regions and different years during this decade,the trends of Ng resistance to CRO were different and fluctuated. The analysis of references showed that the trend of Ng sensibility to CRO declined,although regional differences existed on the whole over the last decade.
To investigate the situation and tendency of ceftriaxone( CRO) resistance to clinical isolations of Neisseria gonorrhoeae( Ng),all the references related to drug resistance of Ng were retrieved through CNKI databank according to certain criteria. The resistance rates and sensibility of different types of bacteria were classified according to regions and years. A total of 101 documents were eventually amd nationally collected from 2000 to 2010. The average resistance rate of Ng to CRO was 0. 66% and the highest one was 1. 45% in 2008. The average sensibility was 68. 83% and the lowest was56. 44% in 2001. In different regions and different years during this decade,the trends of Ng resistance to CRO were different and fluctuated. The analysis of references showed that the trend of Ng sensibility to CRO declined,although regional differences existed on the whole over the last decade.
引文
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3 乐萍,张媛媛,俞燕红.198株淋病奈瑟球菌的耐药性分析[J].海峡药学,2012,24(4):216
4 陈昭丽,张兴艳,李苌青,等.肠杆菌科细菌对头孢曲松耐药趋势的国内文献分析[J].中华医院感染学杂志,2011,21(9):1873-1876
5 程英,王祥兴,汤全贵,等.2000年上海地区淋球菌对抗生素的敏感性测定[J].临床皮肤科杂志,2002,31(3):151-152
6 黎帆,宋矿余.南昌地区淋球菌对抗生素耐药性研究[J].江西医学院学报,2004,44(3):37-38
7 雍刚,杨曦,谭俊,等.2000~2004年成都地区淋球菌耐药性监测[J].中国艾滋病性病,2006,12(3):242-244
8 吴兴中,郑和平,黄进梅,等.广州地区2000~2004年淋球菌对抗菌药物耐药性的变迁[J].中国临床药学杂志,2006,15(5):277-279
9 曹文苓,宋卫忠,黎小东,等.广州地区淋球菌对5种抗生素耐药性结果分析[J].中国麻风皮肤病杂志,2002,18(2):136-137
10 王建中,许敏鸿,蔡小丹,等.汕头市淋球菌耐药菌株和质粒图谱测定[J].中国麻风皮肤病杂志,2003,19(1):8-10
11 周渭珩,裘新民,许爱娥.杭州地区64株淋球菌流行株对抗菌药物的敏感性测定[J].中华皮肤科杂志,2002,35(3):58
12 苏晓红,戴秀芹,孙厚华,等.1999~2002年南京地区淋球菌分离株抗生素敏感性监测[J].中华皮肤科杂志,2004,37(5):16-18
13 杨永军,倪立恒,韩珍.济宁地区淋球菌对抗生素的敏感性测定分析[J].中国艾滋病性病,2005,11(1):48-49
14 顾伟鸣,杨阳,吴磊,等.1988~2002年上海分离的淋球菌对抗菌药的敏感性监测[J].中华皮肤科杂志,2004,37(6):11-13
15 方谷芬,刘湘林,袁正泉.岳阳地区266株淋球菌药敏结果分析[J].医学临床研究,2007,24(4):617-619
16 曹文苓,李嘉彦,黎小东,等.1998~2002年广州地区淋球菌对抗生素耐药性的变迁[J].中国微生态学杂志,2003,15(6):48-49
17 杨晓波,舒仁瑜,刘岚.儿童淋球菌感染及耐药状况分析[J].现代医药卫生,2003,19(4):397-398
18 曹文苓,黎小东,李嘉彦,等.淋球菌对五种抗生素的耐药性连续六年监测结果分析[J].中华检验医学杂志,2004,27(11):45-47
19 蒋法兴,其木格,戴秀琴,等.2003~2006年南京地区淋球菌分离株抗菌药物敏感性监测[J].中国麻风皮肤病杂志,2008,24(1):23-25
20 王长娴,王蓓,汪宁,等.江苏省淋病奈瑟菌对抗菌药物的敏感性分析[J].中华检验医学杂志,2005,28(10):55-56
21 曹文苓,黎小东,毕超,等.广州地区2004年淋球菌对5种抗生素耐药性的监测[J].现代预防医学,2005,32(11):103-104
22 吴兴中,郑和平,黄进梅,等.广州地区淋病奈瑟菌耐药性分析[J].中国感染与化疗杂志,2007,7(3):215-218
23 曹文苓,黎小东,张锡宝,等.2005年广州地区淋球菌对6种抗生素耐药性结果分析[J].热带医学杂志,2006,6(8):952-953
24 曾斤日,何玥,黄江浩,等.深圳市宝安区淋球菌对19种抗生素耐药现状[J].现代预防医学,2007,34(23):4565-4566
25 侯存军,刘庆东,吴学忠,等.济南地区淋球菌耐药性检测及质粒谱型分析[J].中国皮肤性病学杂志,2008,22(1):34-36
26 余克花,余勍,莫冰,等.2006-2008年南昌地区淋球菌耐药检测结果分析[J].江西医学院学报,2009,49(1):134-135
27 柯丹,刁庆春,代详安,等.淋球菌对5种抗菌药物敏感性的监测分析[J].中国皮肤性病学杂志,2008,22(9):549-550
28 赵建妹,胡丽华,高锦伦,等.118株淋球菌耐药检测结果[J].浙江预防医学,2009,21(4):32-34
29 李燕娃,潘洪亮,吴兴中.佛山地区淋球菌流行株对抗生素敏感性测定[J].热带医学杂志,2009,9(7):796-798
30 吴兴中,郑和平,曾维英,等.淋球菌流行株抗生素敏感性监测[J].岭南皮肤性病科杂志,2008,15(3):121-123
31 戴秀芹,孙厚华,尹跃平.2007年南京地区淋球菌分离株对抗生素的敏感性测定[J].中国艾滋病性病,2009,15(2):183-184
32 郭炽星,李小靖,郭廷学,等.淋球菌流行株对5种抗生素敏感性分析[J].国际检验医学杂志,2009,30(6):566-567
33 祝新,黄海花,柯建良,等.2008年江门市区淋球菌分离株抗生素耐药性分析[J].广东医学院学报,2009,27(6):639-641
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