2型糖尿病患者高同型半胱氨酸与糖尿病血管病变相关性研究进展
摘要
<正>糖尿病肾病(diabetic kidney disease,DKD)是2型糖尿病严重的并发症和主要死亡原因之一。中国约有20%～40%的糖尿病肾病患者,已成为终末期肾病的主要病因之一~([1-2])。因而探明糖尿病肾病的发生及发展的机制对糖尿病肾病的防治尤为重要~([3])。由于糖尿病肾病在早期可无蛋白尿,容易被临床医生所忽略,错过最佳治疗时间,戴君~([4])等研究发现如果进一步发展成临床蛋白尿,肾脏损害将进入不可逆转阶段,提示病情较重,这时治疗疗效差,且经济负担较重,故早期诊断DKD,及时干预可大大的改善DKD患者的生活质量。随
引文
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[2]Hu J,Yang S,Zhang Aetal.Abdominalobesityismoreclosely associated with diabetic kidney disease than general obesity[J].Diabetes Care,2016,39(10):179-180.
[3]吴文静,朱志扬,范书英,等.超敏C反应蛋白和同型半胱氨酸与早期糖尿病肾病的相关性研究[J].中国全科医学,2013,16(5),1705-1707.
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[5]董佳敏,蔡薇.同型半胱氨酸与相关疾病的研究进展[J].浙江临床医学,2016,11,2152-2153.
[6]程丝,冯娟,王宪,等.高同型半胱氨酸血症治疗研究进展[J].生理科学进展,2011,42(5):329-334.
[7]戴卫健,赵洪灿,项国谦,等.血清同型半胱氨酸和载脂蛋白水平检测及相关性分析[J].心肺血管病防治,2016,16(2):150-152.
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[9]Ji L,Hu D,Pan C,etal.Primacyofthe 3B approach to control risk factors for cardiovascular disease in type 2 diabetes patients[J].Am J Med,2013,126(10):922-925.
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[11]Christine PJ,Auchincloss AH,Bertoni AG,et al.Longitudinal Associations Between Neighborhood Physical and Social Environments and Incident Type 2 Diabetes Mellitus:The Multi-Ethnic Study of Atherosclerosis(MESA)[J].JAMA Intern Med,2015,175(8):1311-1320.
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[13]霍晓静,洪利华.DM2患者不同Hcy及Cys-C水平与大血管病变的关系[J].放射免疫学杂志,2013,26(5):630-632.
[14]刘宋芳,王述进,左红,等.2型糖尿病患者同型半胱氨酸与大血管病变的关系[J].中国循环杂志,2015,30(2):130-132.
[15]Otoda T,Kanasaki K,Koya D.Low-protein diet for diabetic nephropathy[J].Curr Diab Rep,2014,14(9):523.
[16]朱苏兰,鲁陈,何莹.血Hcy、D-二聚体联合检测在2型糖尿病微血管早起病变诊断中的应用价值研究[J].现代诊断与治疗,2015,17:4010-4011.
[17]纪昕,岳晓乐,赵丹丹,等.同型半胱氨酸与动脉粥样硬化患者血管内皮细胞损伤相关性[J].标记免疫分析与临床,2017,24(1):73-76.
[18]刘菊,梅群超.2型糖尿病微血管病变患者血浆同型半胱氨酸、胱抑素C水平及血液流变学指标变化[J].微循环学杂志,2012,22(3):39-41.
[19]Mao S,Xiang W,Huang S,et al.Association between homocysteine status and the risk of nephropathy in type2 diabetes mellitus[J].Clin Chim Acta,2014,431:206-210.
[20]Harun Kundia,Emrullah Kiziltunca,Ihsan Atesb,et al.Association between plasma homocysteine levels and endorgan damage in newly diagnosed type2 diabetes mellitus patients[J].Endocrine Research,2017,42(1):36-41.
[21]元海萍,吕卫华,武琳,等.糖化血红蛋白、同型半胱氨酸及尿微量白蛋白与2型糖尿病合并肾脏微血管病变的关系研究[J].中国实验诊断学,2015,19(11)1840-1843.
[22]任允斌,薛李荣.探讨同型半胱氨酸、糖化血红蛋白和尿微量白蛋白联合检测对糖尿病早期肾脏损伤的价值[J].糖尿病新世界,2014,6:47-48.
[23]Hellemons ME,Kerschbaum J,Bakker SJ,et al.Validi-tyofbio Mark Validity of biomarkers predicting onset or progression of nephropathy in patients with Type 2 diabetes:a systema tic review[J].Diabetmed,2012,29(5):567-577.
[24]董燕燕,陈光亮.高同型半胱氨酸血症危害及致病机制研究进展[J].中国药理学通报,2014,30(9):1205-1208.
[25]石宇杰,孙琪,牛丽丽,等.高同型半胱氨酸的致病机制及治疗探析[J].中华心脏与心律电子杂志,2016,11(4):251-253.
[26]Sharma S,Singh M,Sharma PL.Mechanism of hype rhom ocyste inemia-induced vascular endothelium dysf unction-possible dys regulation of phosphatidylin osito l-3-kinase and its downs tream phosphoinositide dependent kinase and protein kinase B[J].Eur J Pharmacol,2013,721(1):365-72.
[27]Dong D,Wang B,Yin W,et al.Disturbance of copper homeostasis is a mechanism for homocysteine-induced vascular endothelial cell injury[J].PloS One,2013,8(10):209.
[28]Meng S,Ciment S,Jan M,et al.Homocysteine induces inflammatory transcriptional signaling in monocytes[J].Front Biosci(Landmark Ed),2013,18:685-695.
[29]Wada J,Makino H.Inflammation and the pathogenesis of diabetic nephropathy[J].Clin Sci(Lond),2013,124:139-152.
[2]Hu J,Yang S,Zhang Aetal.Abdominalobesityismoreclosely associated with diabetic kidney disease than general obesity[J].Diabetes Care,2016,39(10):179-180.
[3]吴文静,朱志扬,范书英,等.超敏C反应蛋白和同型半胱氨酸与早期糖尿病肾病的相关性研究[J].中国全科医学,2013,16(5),1705-1707.
[4]戴君,翁敏.2型糖尿病肾病相关危险因素分析[J].现代医药卫生,2015,31(11),1667-1669.
[5]董佳敏,蔡薇.同型半胱氨酸与相关疾病的研究进展[J].浙江临床医学,2016,11,2152-2153.
[6]程丝,冯娟,王宪,等.高同型半胱氨酸血症治疗研究进展[J].生理科学进展,2011,42(5):329-334.
[7]戴卫健,赵洪灿,项国谦,等.血清同型半胱氨酸和载脂蛋白水平检测及相关性分析[J].心肺血管病防治,2016,16(2):150-152.
[8]Ashjazadeh N,Fathi M,Shariat A.Evaluation of homocysteine level as a risk factor among patients with ischemic stroke and its subtypes[J].Iran J Med Sci,2013,38(3):233-239.
[9]Ji L,Hu D,Pan C,etal.Primacyofthe 3B approach to control risk factors for cardiovascular disease in type 2 diabetes patients[J].Am J Med,2013,126(10):922-925.
[10]Peng HY,Man C F,Xu J,et al.Elevated homocysteine levels and risk of cardiovascular and all-cause mortality:a meta-analysis of prospective studies[J].Zhejiang Univ Sci B,2015,16(1):78-86.
[11]Christine PJ,Auchincloss AH,Bertoni AG,et al.Longitudinal Associations Between Neighborhood Physical and Social Environments and Incident Type 2 Diabetes Mellitus:The Multi-Ethnic Study of Atherosclerosis(MESA)[J].JAMA Intern Med,2015,175(8):1311-1320.
[12]Perlmutter JI,Forbes LT,Krysan DJ,et al.Repurposing the antihistamine terfenadine for antimicrobial activity against Staphylococcus aureus[J].J Med Chem,2014,57(20):8540-8562.
[13]霍晓静,洪利华.DM2患者不同Hcy及Cys-C水平与大血管病变的关系[J].放射免疫学杂志,2013,26(5):630-632.
[14]刘宋芳,王述进,左红,等.2型糖尿病患者同型半胱氨酸与大血管病变的关系[J].中国循环杂志,2015,30(2):130-132.
[15]Otoda T,Kanasaki K,Koya D.Low-protein diet for diabetic nephropathy[J].Curr Diab Rep,2014,14(9):523.
[16]朱苏兰,鲁陈,何莹.血Hcy、D-二聚体联合检测在2型糖尿病微血管早起病变诊断中的应用价值研究[J].现代诊断与治疗,2015,17:4010-4011.
[17]纪昕,岳晓乐,赵丹丹,等.同型半胱氨酸与动脉粥样硬化患者血管内皮细胞损伤相关性[J].标记免疫分析与临床,2017,24(1):73-76.
[18]刘菊,梅群超.2型糖尿病微血管病变患者血浆同型半胱氨酸、胱抑素C水平及血液流变学指标变化[J].微循环学杂志,2012,22(3):39-41.
[19]Mao S,Xiang W,Huang S,et al.Association between homocysteine status and the risk of nephropathy in type2 diabetes mellitus[J].Clin Chim Acta,2014,431:206-210.
[20]Harun Kundia,Emrullah Kiziltunca,Ihsan Atesb,et al.Association between plasma homocysteine levels and endorgan damage in newly diagnosed type2 diabetes mellitus patients[J].Endocrine Research,2017,42(1):36-41.
[21]元海萍,吕卫华,武琳,等.糖化血红蛋白、同型半胱氨酸及尿微量白蛋白与2型糖尿病合并肾脏微血管病变的关系研究[J].中国实验诊断学,2015,19(11)1840-1843.
[22]任允斌,薛李荣.探讨同型半胱氨酸、糖化血红蛋白和尿微量白蛋白联合检测对糖尿病早期肾脏损伤的价值[J].糖尿病新世界,2014,6:47-48.
[23]Hellemons ME,Kerschbaum J,Bakker SJ,et al.Validi-tyofbio Mark Validity of biomarkers predicting onset or progression of nephropathy in patients with Type 2 diabetes:a systema tic review[J].Diabetmed,2012,29(5):567-577.
[24]董燕燕,陈光亮.高同型半胱氨酸血症危害及致病机制研究进展[J].中国药理学通报,2014,30(9):1205-1208.
[25]石宇杰,孙琪,牛丽丽,等.高同型半胱氨酸的致病机制及治疗探析[J].中华心脏与心律电子杂志,2016,11(4):251-253.
[26]Sharma S,Singh M,Sharma PL.Mechanism of hype rhom ocyste inemia-induced vascular endothelium dysf unction-possible dys regulation of phosphatidylin osito l-3-kinase and its downs tream phosphoinositide dependent kinase and protein kinase B[J].Eur J Pharmacol,2013,721(1):365-72.
[27]Dong D,Wang B,Yin W,et al.Disturbance of copper homeostasis is a mechanism for homocysteine-induced vascular endothelial cell injury[J].PloS One,2013,8(10):209.
[28]Meng S,Ciment S,Jan M,et al.Homocysteine induces inflammatory transcriptional signaling in monocytes[J].Front Biosci(Landmark Ed),2013,18:685-695.
[29]Wada J,Makino H.Inflammation and the pathogenesis of diabetic nephropathy[J].Clin Sci(Lond),2013,124:139-152.