血府逐瘀汤联合帕罗西汀治疗脑卒中后抑郁的临床效果
|
摘要
目的分析血府逐瘀汤联合帕罗西汀治疗脑卒中后抑郁的临床效果。方法选择2014年3月至2018年3月我院收治的52例脑卒中后抑郁患者为研究对象,随机将其分为试验组和参照组,各26例。参照组给予帕罗西汀治疗,试验组在参照组的基础上给予血府逐瘀汤治疗。比较两组患者的治疗效果。结果治疗4周后,两组患者的HAMD评分均显著降低,且试验组低于参照组(P<0.05)。试验组患者的治疗总有效率为92.31%,高于参照组的69.23%(P<0.05)。治疗4周后,两组患者的NIHSS评分均显著降低,且试验组低于参照组(P<0.05)。结论血府逐瘀汤联合帕罗西汀治疗脑卒中后抑郁患者的效果显著,可降低患者的抑郁程度,改善患者的神经功能缺损,临床应用价值高。
Objective To analyze the clinical effect of Xuefu Zhuyu decoction combined with paroxetine in the treatment of post-stroke depression. Methods Fifty-two patients with post-stroke depression admitted in our hospital from March 2014 to March 2018 were randomly divided into experimental group and reference group, with 26 cases in each group. The reference group was treated with paroxetine and the experimental group was treated with Xuefu Zhuyu decoction on the basis of the reference group. The therapeutic effects of the two groups were compared. Results After 4 weeks of treatment,the HAMD scores of both groups significantly decreased, and that in the experimental group was lower than the reference group(P<0.05). The total effective rate of treatment in the experimental group was 92.31%, which was higher than 69.23%of the reference group(P<0.05). After 4 weeks of treatment, the NIHSS scores of both groups significantly decreased, and that in the experimental group was lower than the reference group(P<0.05). Conclusion Xuefu Zhuyu decoction combined with paroxetine in the treatment of post-stroke depression patients has a significant effect, can reduce the degree of depression, improve the neurological deficits of patients, with high clinical value.
Objective To analyze the clinical effect of Xuefu Zhuyu decoction combined with paroxetine in the treatment of post-stroke depression. Methods Fifty-two patients with post-stroke depression admitted in our hospital from March 2014 to March 2018 were randomly divided into experimental group and reference group, with 26 cases in each group. The reference group was treated with paroxetine and the experimental group was treated with Xuefu Zhuyu decoction on the basis of the reference group. The therapeutic effects of the two groups were compared. Results After 4 weeks of treatment,the HAMD scores of both groups significantly decreased, and that in the experimental group was lower than the reference group(P<0.05). The total effective rate of treatment in the experimental group was 92.31%, which was higher than 69.23%of the reference group(P<0.05). After 4 weeks of treatment, the NIHSS scores of both groups significantly decreased, and that in the experimental group was lower than the reference group(P<0.05). Conclusion Xuefu Zhuyu decoction combined with paroxetine in the treatment of post-stroke depression patients has a significant effect, can reduce the degree of depression, improve the neurological deficits of patients, with high clinical value.
引文
[1]岳祥海,孙新刚,梁蔚骏,等.卒中后抑郁的流行病学研究进展[J].中华临床医师杂志:电子版,2016,10(12):1790-1794.
[2]汪昆.盐酸帕罗西汀对治疗脑卒中后抑郁的临床作用研究[J].陕西医学杂志,2016,45(4):490-491.
[3]赵建国,高长玉,顼宝玉,等.脑梗死和脑出血中西医结合诊断标准(试行)[J].中国中西医结合杂志,2006,26(10):948-949.
[4]中华医学会精神病学分会.中国精神障碍分类与诊断标准第三版(精神障碍分类)[J].中华精神科杂志,2001,34(3):184-188.
[5]邵宏敏.溴化钠苯甲酸钠咖啡因合剂联合帕罗西丁治疗脑卒中后抑郁疗效分析[J].中国误诊学杂志,2010,10(24):5834-5835.
[6]张丽萍,詹乐昌,谢雁鸣,等.中西医结合治疗方案对急性缺血性脑卒中患者神经功能缺损和致残结局的影响[J].中国中西医结合杂志,2011,31(9):1175-1180.
[7]杨莹莹,潘永惠,王森.脑卒中后抑郁的研究进展[J].医学研究杂志,2016,45(4):168-170.
[8]王琳.血府逐瘀汤联合帕罗西丁治疗脑卒中后抑郁患者的临床疗效观察[J].中国医药指南,2018,16(3):7-8.
[9]王岗.血府逐瘀汤联合西药治疗急性缺血性脑卒中效果及对血清炎症因子、血液流变学的影响[J].临床医学研究与实践,2018,3(19):122-123.
[2]汪昆.盐酸帕罗西汀对治疗脑卒中后抑郁的临床作用研究[J].陕西医学杂志,2016,45(4):490-491.
[3]赵建国,高长玉,顼宝玉,等.脑梗死和脑出血中西医结合诊断标准(试行)[J].中国中西医结合杂志,2006,26(10):948-949.
[4]中华医学会精神病学分会.中国精神障碍分类与诊断标准第三版(精神障碍分类)[J].中华精神科杂志,2001,34(3):184-188.
[5]邵宏敏.溴化钠苯甲酸钠咖啡因合剂联合帕罗西丁治疗脑卒中后抑郁疗效分析[J].中国误诊学杂志,2010,10(24):5834-5835.
[6]张丽萍,詹乐昌,谢雁鸣,等.中西医结合治疗方案对急性缺血性脑卒中患者神经功能缺损和致残结局的影响[J].中国中西医结合杂志,2011,31(9):1175-1180.
[7]杨莹莹,潘永惠,王森.脑卒中后抑郁的研究进展[J].医学研究杂志,2016,45(4):168-170.
[8]王琳.血府逐瘀汤联合帕罗西丁治疗脑卒中后抑郁患者的临床疗效观察[J].中国医药指南,2018,16(3):7-8.
[9]王岗.血府逐瘀汤联合西药治疗急性缺血性脑卒中效果及对血清炎症因子、血液流变学的影响[J].临床医学研究与实践,2018,3(19):122-123.