芡实超微粉的体内降血脂功效
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摘要
采用不同剂量的芡实超微粉对高脂模型小鼠进行灌胃,研究芡实超微粉对高脂模型小鼠血脂四项指标及血清和肝组织中相关酶类的影响。结果发现,与高脂模型组相比,灌胃芡实超微粉组小鼠体重明显降低,肝脏指数和动脉粥样硬化指数也明显降低;小鼠血清总胆固醇(total cholesterol,TC)、甘油三脂(triglyceride,TG)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)水平均明显降低,高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)水平则显著升高;灌胃芡实超微粉低、中、高剂量组小鼠的总超氧化物歧化酶(total superoxide dismutase,T-SOD)和肝酯酶(hepatic lipase,HL)活力均高于高脂模型组,而丙二醛(malondialdehyde,MDA)含量要低于高脂模型组。由此可知,芡实超微粉可降低高血脂症小鼠血脂水平,改善其因摄入过多脂质而导致的肝脏脂肪堆积和动脉粥样硬化,并对高血脂症引起的脂质过氧化损伤具有防护作用。
High-fat model mice were given intragastric administration with different doses of tamping ultrafine powder to study the effect of ultra-fine powder on the four indicators of serum lipids and related enzymes in serum and liver tissue. The results showed that compared with the high-fat model group,the body weight of mice fed the ultra-fine powder group was significantly reduced,liver index and atherosclerosis index were also significantly reduced;serum total cholesterol(TC),triglyceride(TG),and low density lipoprotein cholesterol(LDL-C) levels in mice Significantly lower,high density lipoprotein cholesterol(HDL-C) levels were significantly higher;the total superoxide dismutase(T-SOD)and hepatic lipase(HL)activity in the low-,medium-,and high-dose groups of mice fed ultra-fine powder was higher than that in the high-fat model group,and the malondialdehyde(MDA)content was increased. Lower than the high fat model group. It can be seen that the ultrafine powder can reduce blood lipid levels in hyperlipidemia mice and improve the degree of hepatic fat accumulation and atherosclerosis caused by excessive lipid intake and it also has protective effect on lipid peroxidation injury caused by hyperlipidemia.
High-fat model mice were given intragastric administration with different doses of tamping ultrafine powder to study the effect of ultra-fine powder on the four indicators of serum lipids and related enzymes in serum and liver tissue. The results showed that compared with the high-fat model group,the body weight of mice fed the ultra-fine powder group was significantly reduced,liver index and atherosclerosis index were also significantly reduced;serum total cholesterol(TC),triglyceride(TG),and low density lipoprotein cholesterol(LDL-C) levels in mice Significantly lower,high density lipoprotein cholesterol(HDL-C) levels were significantly higher;the total superoxide dismutase(T-SOD)and hepatic lipase(HL)activity in the low-,medium-,and high-dose groups of mice fed ultra-fine powder was higher than that in the high-fat model group,and the malondialdehyde(MDA)content was increased. Lower than the high fat model group. It can be seen that the ultrafine powder can reduce blood lipid levels in hyperlipidemia mice and improve the degree of hepatic fat accumulation and atherosclerosis caused by excessive lipid intake and it also has protective effect on lipid peroxidation injury caused by hyperlipidemia.
引文
[1]赵翾,李红良,叶倩雯.芡实多糖的粗提取及其对羟自由基的清除效果[J].食品与发酵工业,2010,36(11):177-182
[2]覃容贵,吴建伟,国果,等.蝇蛆壳聚糖降血脂作用机制探讨[J].中国生化药物杂志,2011,32(4):294-296
[3]于飞.薏苡仁提取物抗肿瘤新靶点及降血脂抗氧化活性研究[D].天津:天津大学,2010
[4]张萍.金花茶的花提取物降血脂作用研究[D].大连:大连理工大学,2015
[5]杨晓曦,程晓晨,卢育新,等.芡实醇提物对糖尿病肾病大鼠肾功能的影响及其体外抗氧化能力测定[J].国际药学研究杂志,2015,42(3):380-385
[6]Cheng-Ying Wu,Hong Wang,Xiao-Xiao He,et al.The hypoglycemic and antioxidant effects of polysaccharides from the petioles and pedicels of Euryale ferox Salisb.on alloxan-induced hyperglycemic mice[J].Food&Function,2017,8(10):3803-3813
[7]李湘利,刘静,燕伟,等.芡实多糖的抗氧化性及抑菌特性[J].食品与发酵工业,2014,40(11):104-108
[8]Ahmed Danish,Sharma Manju,Kumar Vikas,et al.2β-hydroxybetulinic acid 3β-caprylate:an active principle from Euryale Ferox Salisb.seeds with antidiabetic,antioxidant,pancreas&hepatoprotective potential in streptozotocin induced diabetic rats[J].Journal of Food Science and Technology,2015,52(9):5427-5441
[9]杨佩磊,蒋剑平,李全清,等.胡柚皮黄酮对高脂血症大鼠的降血脂作用研究[J].中国中药杂志,2017,42(5):936-943
[10]蔡杰.EGCG和白藜芦醇对大鼠高脂性脂肪肝的降脂作用研究[D].长沙:湖南农业大学,2012
[11]Lairon D,Play B,Jourdheuil-Rahmani D.Digestible and indigestible carbohydrates:interactions with postprandial lipid metabolism[J].JNutr Biochem,2007,18(4):217
[12]Bosca A R,Gutierrez M A C,Soler A,et al.Effects of the antioxidant turmeric on lipoprotein peroxides:Implications for the prevention of atherosclerosis[J].AGE,1997,20(3):165-168
[13]Huijuan Jing,Juan Li,Jianjun Zhang,et al.The antioxidative and anti-aging effects of acidic-and alkalic-extractable mycelium polysaccharides by Agrocybe aegerita(Brig.)Sing[J].International Journal of Biological Macromolecules,2018,106:1270-1278
[14]Matthijsen R A,De Winther M P J,Kuipers D,et al.MacrophageSpecific Expression of Mannose-Binding Lectin Controls Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice[J].Circulation,2009,119(16):2188-2195
[15]游庭活.桑椹多酚类化合物抗氧化及延缓衰老作用研究[D].广州:广东药学院,2015
[2]覃容贵,吴建伟,国果,等.蝇蛆壳聚糖降血脂作用机制探讨[J].中国生化药物杂志,2011,32(4):294-296
[3]于飞.薏苡仁提取物抗肿瘤新靶点及降血脂抗氧化活性研究[D].天津:天津大学,2010
[4]张萍.金花茶的花提取物降血脂作用研究[D].大连:大连理工大学,2015
[5]杨晓曦,程晓晨,卢育新,等.芡实醇提物对糖尿病肾病大鼠肾功能的影响及其体外抗氧化能力测定[J].国际药学研究杂志,2015,42(3):380-385
[6]Cheng-Ying Wu,Hong Wang,Xiao-Xiao He,et al.The hypoglycemic and antioxidant effects of polysaccharides from the petioles and pedicels of Euryale ferox Salisb.on alloxan-induced hyperglycemic mice[J].Food&Function,2017,8(10):3803-3813
[7]李湘利,刘静,燕伟,等.芡实多糖的抗氧化性及抑菌特性[J].食品与发酵工业,2014,40(11):104-108
[8]Ahmed Danish,Sharma Manju,Kumar Vikas,et al.2β-hydroxybetulinic acid 3β-caprylate:an active principle from Euryale Ferox Salisb.seeds with antidiabetic,antioxidant,pancreas&hepatoprotective potential in streptozotocin induced diabetic rats[J].Journal of Food Science and Technology,2015,52(9):5427-5441
[9]杨佩磊,蒋剑平,李全清,等.胡柚皮黄酮对高脂血症大鼠的降血脂作用研究[J].中国中药杂志,2017,42(5):936-943
[10]蔡杰.EGCG和白藜芦醇对大鼠高脂性脂肪肝的降脂作用研究[D].长沙:湖南农业大学,2012
[11]Lairon D,Play B,Jourdheuil-Rahmani D.Digestible and indigestible carbohydrates:interactions with postprandial lipid metabolism[J].JNutr Biochem,2007,18(4):217
[12]Bosca A R,Gutierrez M A C,Soler A,et al.Effects of the antioxidant turmeric on lipoprotein peroxides:Implications for the prevention of atherosclerosis[J].AGE,1997,20(3):165-168
[13]Huijuan Jing,Juan Li,Jianjun Zhang,et al.The antioxidative and anti-aging effects of acidic-and alkalic-extractable mycelium polysaccharides by Agrocybe aegerita(Brig.)Sing[J].International Journal of Biological Macromolecules,2018,106:1270-1278
[14]Matthijsen R A,De Winther M P J,Kuipers D,et al.MacrophageSpecific Expression of Mannose-Binding Lectin Controls Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice[J].Circulation,2009,119(16):2188-2195
[15]游庭活.桑椹多酚类化合物抗氧化及延缓衰老作用研究[D].广州:广东药学院,2015