摘要
目的观察康莱特注射液辅助治疗晚期非小细胞肺癌(NSCLC)化疗患者的效果。方法选择收治的晚期NSCLC化疗患者64例为研究对象,依据患者是否同意使用康莱特注射液辅助化疗分为KLT组(在TP方案上加用康莱特注射液辅助化疗)和常规组(仅接受TP方案进行常规化疗),每组32例,比较两组患者的客观疗效、肿瘤标记物、基质金属蛋白酶相关因子及不良反应的差异。结果 KLT组客观疗效总有效率明显高于常规组(P<0.05);干预后,两组癌胚抗原(CEA)、糖类抗原125(CA125)、神经烯醇化酶(NSE)水平均明显下降(P<0.05),且KLT组CEA、CA125、NSE水平均低于常规组(P<0.05);干预后,两组基质金属蛋白酶(MMP)-9、MMP-2、MMP-9、基质金属蛋白酶抑制剂(TIMP)-1、TIMP-2水平均明显降低(P<0.05),且KLT组MMP-2、MMP-9、TIMP-1、TIMP-2水平均低于常规组(P<0.05);KLT组的不良反应总发生率(50.00%)明显低于常规组(75.00%),差异有统计学意义(P<0.05)。结论康莱特辅助化疗可降低肿瘤标记物和基质金属蛋白酶相关指标,疗效明显,不良反应少。
Objective To observe the influence of Kanglaite(KLT)injection adjuvant therapy on the effect in the patients with advanced non-small cell lung cancer(NSCLC).Methods Sixty-four cases of NSCLC chemotherapy treated in the hospital were selected as the study subjects and divided into the KLT group(n=32,adding KLT adjuvant chemotherapy based on TP regimen)and routine group(n=32,only receiving the TP regimen for conducting the routine chemotherapy)according to whether the patients agreed to use KLT injection adjuvant chemotherapy.The objective efficacy,tumor markers,matrix metalloproteinase-related factors and adverse reactions were compared between the two groups.Results The total effective rate of objective efficacy in the KLT group was significantly higher than that in the routine group(P<0.05).After intervention,the levels of carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125)and neuronolase(NSE)in the two groups were significantly decreased(P<0.05),moreover the levels of the above tumor markers in the KLT group were lower than those in the routine group(P<0.05).After intervention,the levels of matrix metalloproteinase(MMP)-2,MMP-9,TIMP-1 and TIMP-2 in the two groups significantly decreased(P<0.05),moreover the levels of the above indicators in KLT group were lower than those in routine group(P<0.05).The total incidence rate of adverse reactions in the KLT group was significantly lower than that in the routine group(50.00%vs.75.00%,P<0.05).Conclusion The KLT adjuvant chemotherapy can reduce the levels of tumor markers and matrix metalloproteinase-related indicators with obvious efficacy and few adverse reactions.
引文
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