摘要
目的观察食管通结方对食管癌新辅助化疗患者血清CEA、CYFRA21-1及化疗疗效的影响。方法将68例食管癌中下段伴纵膈和腹腔淋巴结转移的患者,随机分为对照组和治疗组各34例,对照组给予紫杉醇加卡铂方案(紫杉醇175 mg/m2、卡铂AUC=5)化疗2个疗程,治疗组在化疗的基础上加用食管通结方(党参、天龙、急性子、石见穿、制南星、煨诃子、枸橘李)服用2个月。结果治疗后两组血清CEA、CYFRA21-1水平均较治疗前有所下降,治疗组下降更加明显,差异有统计学意义(P <0.05)。并且治疗后,治疗组血清CEA水平和对照组相比明显降低,有统计学意义(P <0.05),血清CYFRA21-1 2组相比下降无统计学差异。治疗组总有效率为76.7%,明显高于对照组41.1%,差异有统计学意义(P <0.05)。结论食管通结方能降低患者化疗后血CEA、CYFRA21-1的水平,提高化疗的治疗效果,在一定程度上起到减瘤增效的作用。
Objective To observe the influence of Shiguan Tongjie decoction on the efficacy and the serum levels of CEA and CYFRA21-1 in patients with esophagus cancer after neoadjuvant chemotherapy. Methods 68 patients with lower esophagus cancer with mediastinum and abdominal lymph node metastasis were randomly divided into control and treatment group, 34 patients in each group. The control group was treated with 2 courses of chemotherapy of paclitaxel plus carboplatin(paclitaxel 175 mg/m2, carboplatin AUC = 5), the treatment group was additionally treated with Shiguan Tongjie decoction for two months. Results After treatment, the levels of serum CEA and CYFRA21-1 in both groups decreased compared with that before treatment, the treatment group was more obvious with significant diff erence(P < 0.05). After treatment, the serum CEA level in the treatment group was significantly lower than that in the control group(P < 0.05), but the lower of serum CYFRA21-1 level shows nostatistical significant diff erence between the two groups. The total eff ective rate of the treatment group was 76.7%, which is significantly higher than that in the control group(41.1%), the diff erence was statistically significant(P < 0.05). Conclusion Shiguan Tongjiedecoction can reduce levels of serum CEA and CYFRY21-1 in patients after neoadjuvant chemotherapy, improve the therapeutic eff ect of chemotherapy. To a certain extent, it can help fight tumor and improve efficacay.
引文
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