盐酸乙哌立松联合水疗治疗老年膝关节骨性关节炎
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摘要
目的探究盐酸乙哌立松联合水疗治疗老年膝关节骨性关节炎(OA)的疗效。方法选取2016年7月至2017年7月收治的老年膝关节OA患者124例,按随机数字表法分为两组,各62例。对照组采用玻璃酸钠关节腔内注射治疗,5 ml/次,1次/d。观察组采用口服盐酸乙哌立松(每次50 mg,每天3次)联合水疗治疗(温水浴中进行膝关节活动训练,每次60 min)。两组均治疗2个月。对比两组治疗前后西安大略和麦克马斯特大学(WOMAC)关节炎指数评分、OA严重指数(ISOA)评分、Ⅱ型胶原C端肽(CTX-Ⅱ)水平。结果两组治疗1个月、2个月后关节疼痛、关节僵硬、活动难度评分及总分均明显低于治疗前(P<0.05),且观察组低于对照组(P<0.01);两组治疗1个月、2个月后ISOA评分均明显低于治疗前(P<0.05),且观察组低于对照组(P<0.01);两组治疗1个月、2个月后CTX-Ⅱ水平均明显低于治疗前(P<0.05),且观察组低于对照组(P<0.01)。结论对老年膝关节骨性关节炎采用盐酸乙哌立松联合水疗治疗,临床疗效优于玻璃酸钠关节腔内注射治疗,有利于促进关节软骨恢复。
Objective To investigate the efficacy of eperisone hydrochloride combined with hydrotherapy in the treatment of elderly patients with knee osteoarthritis(OA).Methods A total of 124 elderly patients with knee OA admitted to hospital from July 2016 to July 2017 were randomly divided into observation group and control group(n=62,each).The sodium hyaluronate was given in control group,and the eperisone hydrochloride combined with hydrotherapy was performed in observation group.The changes of Western Ontario and McMaster Universitiy(WOMAC) arthritis indexes,index of severity for OA(ISOA)and C-terminal crosslinking telopeptide of collagen type Ⅱ(CTX-Ⅱ) content before and after treatment were compared between two groups.Both groups were treated for 2 months.Results After 1-and 2-month of treatment,the scores of joint pain,joint stiffness,dysfunction and total score were significantly lower in two groups than those before treatment(P<0.05),and were lower in observation group than those in control group(P< 0.01);the ISOA was significantly lower than that before treatment(P<0.05) in both groups,and was lower in the observation group than in the control group(P<0.01);the level of CTX-Ⅱ in two groups was significantly lower than that before treatment(P<0.05),and was lower in observation group than that in the control group(P<0.01).Conclusion For elderly knee OA treated with eperisone hydrochloride combined with hydrotherapy,the clinical effect is better than intra-articular injection of sodium hyaluronate,which is beneficial to promote the recovery of articular cartilage.
Objective To investigate the efficacy of eperisone hydrochloride combined with hydrotherapy in the treatment of elderly patients with knee osteoarthritis(OA).Methods A total of 124 elderly patients with knee OA admitted to hospital from July 2016 to July 2017 were randomly divided into observation group and control group(n=62,each).The sodium hyaluronate was given in control group,and the eperisone hydrochloride combined with hydrotherapy was performed in observation group.The changes of Western Ontario and McMaster Universitiy(WOMAC) arthritis indexes,index of severity for OA(ISOA)and C-terminal crosslinking telopeptide of collagen type Ⅱ(CTX-Ⅱ) content before and after treatment were compared between two groups.Both groups were treated for 2 months.Results After 1-and 2-month of treatment,the scores of joint pain,joint stiffness,dysfunction and total score were significantly lower in two groups than those before treatment(P<0.05),and were lower in observation group than those in control group(P< 0.01);the ISOA was significantly lower than that before treatment(P<0.05) in both groups,and was lower in the observation group than in the control group(P<0.01);the level of CTX-Ⅱ in two groups was significantly lower than that before treatment(P<0.05),and was lower in observation group than that in the control group(P<0.01).Conclusion For elderly knee OA treated with eperisone hydrochloride combined with hydrotherapy,the clinical effect is better than intra-articular injection of sodium hyaluronate,which is beneficial to promote the recovery of articular cartilage.
引文
[1] 梁廷营.针灸联合玻璃酸钠治疗膝关节骨性关节炎50例[J].中医研究,2018,31(5):55-57.
[2] 张新冕,张天民.针刀医学对膝关节骨性关节炎病因和疗法的新认识[J].中医外治杂志,2018,27(2):59-60.
[3] Stubbs B,Hurley M,Smith T.What are the factors that influence physical activity participation in adults with knee and hip osteoarthritis?A systematic review of physical activity correlates[J].Clin Rehabil,2015,29(1):80-94.
[4] 殷建波,王敏,任丽,等.经皮电刺激神经疗法配合宣氏强刺激推拿法治疗膝骨性关节炎[J].中医临床研究,2018,10(3):64-67.
[5] 王曦.关节镜选择性清理术治疗膝骨性关节炎的临床疗效分析[J].中西医结合心血管病电子杂志,2018,6(5):65,68.
[6] Dias JM,Cisneros L,Dias R,et al.Hydrotherapy improves pain and function in older women with knee osteoarthritis:a randomized controlled trial[J].Braz J Phys Ther,2017,21(6):449-456.
[7] 蔡立新,王梓懿.臭氧联合玻璃酸钠关节腔内注射治疗膝关节骨性关节炎的疗效观察[J].中西医结合心血管病电子杂志,2018,6(1):170-171.
[8] 王奎.中西医结合治疗膝关节退行性骨性关节炎的临床研究[J].中外医学研究,2018,16(9):34-36.
[9] Patel JM,Ghodbane SA,Brzezinski A,et al.Tissue-engineered total meniscus replacement with a fiber-reinforced scaffold in a 2-year ovine model[J].Am J Sports Med,2018,46(8):1844-1856.
[10] 高娟,方志红.关节镜手术结合早期锻炼干预对膝骨性关节炎患者术后关节功能的影响及疗效[J].中国现代医生,2018,56(11):5-7,11.
[11] 夏卫明,蒋聿瑛,补灿灿.氨基葡萄糖胶囊联合玻璃酸钠治疗膝骨性关节炎的疗效及对炎症因子水平的影响[J].中国现代医生,2018,56(7):16-19.
[12] 周敬杰,张明,张秀芳,等.本体感觉训练联合Kaltenborn关节松动术治疗慢性踝关节不稳的疗效观察[J].中华物理医学与康复杂志,2018,40(2):151-153.
[13] Yoshioka K,Hoshi H,Oshima N,et al.Sustainable duration of different types of cross-linked hyaluronate for knee osteoarthritis[J].Osteoarthritis and Cartilage,2017,25:S437.
[14] 段好阳,闫兆红,李贞兰,等.体外冲击波联合中药药物离子导入治疗老年人膝关节骨性关节炎的临床疗效[J].中华老年医学杂志,2018,37(1):67-70.
[15] 牟卫光.针刺联合推拿治疗膝骨性关节炎的疗效观察及其对血清炎症因子的影响[J].中国中医药科技,2018,25(2):159-161.
[16] 戴涟生,叶俊星,杨晓斐,等.三联药物注射辅助治疗Ⅱ～Ⅲ级老年KOA临床研究[J].中国医院药学杂志,2018,38(3):295-297,261.
[2] 张新冕,张天民.针刀医学对膝关节骨性关节炎病因和疗法的新认识[J].中医外治杂志,2018,27(2):59-60.
[3] Stubbs B,Hurley M,Smith T.What are the factors that influence physical activity participation in adults with knee and hip osteoarthritis?A systematic review of physical activity correlates[J].Clin Rehabil,2015,29(1):80-94.
[4] 殷建波,王敏,任丽,等.经皮电刺激神经疗法配合宣氏强刺激推拿法治疗膝骨性关节炎[J].中医临床研究,2018,10(3):64-67.
[5] 王曦.关节镜选择性清理术治疗膝骨性关节炎的临床疗效分析[J].中西医结合心血管病电子杂志,2018,6(5):65,68.
[6] Dias JM,Cisneros L,Dias R,et al.Hydrotherapy improves pain and function in older women with knee osteoarthritis:a randomized controlled trial[J].Braz J Phys Ther,2017,21(6):449-456.
[7] 蔡立新,王梓懿.臭氧联合玻璃酸钠关节腔内注射治疗膝关节骨性关节炎的疗效观察[J].中西医结合心血管病电子杂志,2018,6(1):170-171.
[8] 王奎.中西医结合治疗膝关节退行性骨性关节炎的临床研究[J].中外医学研究,2018,16(9):34-36.
[9] Patel JM,Ghodbane SA,Brzezinski A,et al.Tissue-engineered total meniscus replacement with a fiber-reinforced scaffold in a 2-year ovine model[J].Am J Sports Med,2018,46(8):1844-1856.
[10] 高娟,方志红.关节镜手术结合早期锻炼干预对膝骨性关节炎患者术后关节功能的影响及疗效[J].中国现代医生,2018,56(11):5-7,11.
[11] 夏卫明,蒋聿瑛,补灿灿.氨基葡萄糖胶囊联合玻璃酸钠治疗膝骨性关节炎的疗效及对炎症因子水平的影响[J].中国现代医生,2018,56(7):16-19.
[12] 周敬杰,张明,张秀芳,等.本体感觉训练联合Kaltenborn关节松动术治疗慢性踝关节不稳的疗效观察[J].中华物理医学与康复杂志,2018,40(2):151-153.
[13] Yoshioka K,Hoshi H,Oshima N,et al.Sustainable duration of different types of cross-linked hyaluronate for knee osteoarthritis[J].Osteoarthritis and Cartilage,2017,25:S437.
[14] 段好阳,闫兆红,李贞兰,等.体外冲击波联合中药药物离子导入治疗老年人膝关节骨性关节炎的临床疗效[J].中华老年医学杂志,2018,37(1):67-70.
[15] 牟卫光.针刺联合推拿治疗膝骨性关节炎的疗效观察及其对血清炎症因子的影响[J].中国中医药科技,2018,25(2):159-161.
[16] 戴涟生,叶俊星,杨晓斐,等.三联药物注射辅助治疗Ⅱ～Ⅲ级老年KOA临床研究[J].中国医院药学杂志,2018,38(3):295-297,261.