永瓣藤茎叶中2个新的β-二氢沉香呋喃型倍半萜
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摘要
目的研究永瓣藤Monimopetalum chinense茎叶的化学成分。方法采用硅胶柱色谱和制备液相色谱技术等多种方法分离永瓣藤的化学成分,并综合运用NMR、HR-ESI-MS等波谱手段鉴定化合物的结构。结果从永瓣藤茎叶甲醇提取物中分离得到2个新的β-二氢沉香呋喃型倍半萜,分别鉴定为1α,6β-二烟酰氧基-9α-乙酰基-β-二氢沉香呋喃(1)、1α,6β-二烟酰氧基-9α-苯甲酰氧基-8α-羟基-β-二氢沉香呋喃(2)。结论化合物1和2均为新化合物,分别命名为永瓣藤素I和永瓣藤素II。
Objective To study the chemical constituents from the stems and leaves of Monimopetalum chinense. Methods The constituents were isolated and purified by silica gel column chromatography and preparative HPLC. Their structures were elucidated based on spectroscopic methods including 1 D and 2 D NMR and HR-ESI-MS. Results Two new dihydro-β-agarofuran sesquiterpenes were isolated from the stems and leaves of M. chinense and identified as 1α,6β-dinicotinoyloxy-9α-acetoxy-dihydro-β-agarofuran(1) and 1α,6β-dinicotinoyloxy-9α-benzoyloxy-8α-hydroxydihydro-β-agarofuran(2). Conclusion Compounds 1 and 2 are new compounds, and named as monimins I and II, respectively.
Objective To study the chemical constituents from the stems and leaves of Monimopetalum chinense. Methods The constituents were isolated and purified by silica gel column chromatography and preparative HPLC. Their structures were elucidated based on spectroscopic methods including 1 D and 2 D NMR and HR-ESI-MS. Results Two new dihydro-β-agarofuran sesquiterpenes were isolated from the stems and leaves of M. chinense and identified as 1α,6β-dinicotinoyloxy-9α-acetoxy-dihydro-β-agarofuran(1) and 1α,6β-dinicotinoyloxy-9α-benzoyloxy-8α-hydroxydihydro-β-agarofuran(2). Conclusion Compounds 1 and 2 are new compounds, and named as monimins I and II, respectively.
引文
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[14]赖学文,姚振生,盛晓静.永瓣藤的生药鉴定[J].江西中医学院学报,1997,9(1):29.
[2]Rehder A.Monimopetalum,a new genus of Celastraceae[J].J Arnold Arboretum,1926,7(4):233-234.
[3]Gao J M,Wu W J,Zhang J W,et al.The dihydro-beta-agarofuran sesquiterpenoids[J].Nat Prod Rep,2007,24(5):1153-1189.
[4]Wang D M,Zhang C C,Zhang Q N,et al.Wightianines A-E,dihydro-beta-agarofuran sesquiterpenes from Parnassia wightiana,and their antifungal and insecticidal activities[J].J Agric Food Chem,2014,62(28):6669-6676.
[5]Chen J J,Chou T H,Peng C F,et al.Antitubercular dihydroagarofuranoid sesquiterpenes from the roots of Microtropis fokienensis[J].J Nat Prod,2007,70(2):202-205.
[6]Chen J J,Yang C S,Peng C F,et al.Dihydroagarofuranoid sesquiterpenes,a lignan derivative,a benzenoid,and antitubercular constituents from the stem of Microtropis japonica[J].J Nat Prod,2008,71(6):1016-1021.
[7]Weng J R,Yen M H.New dihydroagarofuranoid sesquiterpenes from Celastrus paniculatus[J].Helv Chim Acta,2010,93(9):1716-1724.
[8]Xu J,Lu J,Sun F,et al.Terpenoids from Tripterygium wilfordii[J].Phytochemistry,2011,72(11/12):1482-1487.
[9]Luo Y,Zhou M,Ye Q,et al.Dihydroagarofuran derivatives from the dried roots of Tripterygium wilfordii[J].J Nat Prod,2012,75(1):98-102.
[10]Garcia M E,Motrich R D,Caputto B L,et al.Agarofuran sesquiterpenes from Schaefferia argentinensis[J].Phytochemistry,2013,94(5):260-267.
[11]Gutierrez-Nicolas F,Oberti J C,Ravelo A G,et al.β-agarofurans and sesquiterpene pyridine alkaloids from Maytenus spinosa[J].J Nat Prod,2014,77(8):1853-1863.
[12]Alarcon J,Cespedes C L,Munoz E,et al,Dihydroagarofuranoid sesquiterpenes as acetylcholinesterase inhibitors from Celastraceae plants:Maytenus disticha and Euonymus japonicas[J].J Agric Food Chem,2015,63(47):10250-10256.
[13]Wibowo M,Levrier C,Sadowski M C,et al.Bioactive dihydro-beta-agarofuran sesquiterpenoids from the Australian rainforest plant Maytenus bilocularis[J].J Nat Prod,2016,79(5):1445-1453.
[14]赖学文,姚振生,盛晓静.永瓣藤的生药鉴定[J].江西中医学院学报,1997,9(1):29.