分子印迹技术原理及在标准物质定值中的应用
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摘要
分子印迹技术是制备具有特异预定选择性的高分子化合物——分子印迹聚合物的技术,也是当前分析化学领域研究的热点。该技术是模仿钥匙的原理,即在印迹分子(模板)存在的条件下,在模板周围合成特定聚合物,之后将模板移出,形成特定孔穴。它具有高选择性、分子识别、可具有针对性设计等特点,表现出较高的应用潜力。在标准物质定值当中多组分分离、痕量组分富集是研究的难点,而这却是分子印迹技术的优势,因而分子印迹技术在标准物质定值工作中具有很高的应用价值。
Molecular imprinting is a technique for preparing polymer with specific predetermined selectivity. The technique mimics the key principle of synthesizing a specific polymer around the template in the presence of imprinted molecules(templates) and then removing the template to form a specific hole. It has the characteristics of high selectivity, molecular recognition and targeted design, showing high application potential. In standard set material as multicomponent separation and enrichment of trace components is a key problem for study, and this is the advantage of molecular imprinting technique and molecularly imprinted technique in the standard material constant value work has the very high application value.
Molecular imprinting is a technique for preparing polymer with specific predetermined selectivity. The technique mimics the key principle of synthesizing a specific polymer around the template in the presence of imprinted molecules(templates) and then removing the template to form a specific hole. It has the characteristics of high selectivity, molecular recognition and targeted design, showing high application potential. In standard set material as multicomponent separation and enrichment of trace components is a key problem for study, and this is the advantage of molecular imprinting technique and molecularly imprinted technique in the standard material constant value work has the very high application value.
引文
[1]国家质量监督检验检疫总局.标准物质定值的通用原则及统计学原理:JJF 1343-2012[S].2012.
[2]Wulff G,Sarhan A,The use of polymers with enzyme-analogous structures for the resolution of racemates[J].Angew.Chem.Int.Ed.,1972,11(4):341-344.
[3]Vlatakis G,Andersson L I,Muller R,et al.Drug assay using antibody mimics made by molecular imprinting[J].Nature,1993,361:645-647.
[4]Matsui J,Nicholls I A,Takeuchi T.Molecular recognition in cinchona alkaloid molecular imprinted polymer rods[J].Anal.Chim.Acta,1998,365(1):89-93.
[5]常子栋,刘伟,高楠莎,等.分子印迹聚合物膜修饰电极的制备及在香草醛测量中的应用[J].分析试验室,2013(2):6-11.
[2]Wulff G,Sarhan A,The use of polymers with enzyme-analogous structures for the resolution of racemates[J].Angew.Chem.Int.Ed.,1972,11(4):341-344.
[3]Vlatakis G,Andersson L I,Muller R,et al.Drug assay using antibody mimics made by molecular imprinting[J].Nature,1993,361:645-647.
[4]Matsui J,Nicholls I A,Takeuchi T.Molecular recognition in cinchona alkaloid molecular imprinted polymer rods[J].Anal.Chim.Acta,1998,365(1):89-93.
[5]常子栋,刘伟,高楠莎,等.分子印迹聚合物膜修饰电极的制备及在香草醛测量中的应用[J].分析试验室,2013(2):6-11.