藏药匙叶翼首草化学成分研究
摘要
目的对川续断科翼花属多年生植物匙叶翼首草(Pterocephalushookeri)全株的化学成分进行研究。方法利用硅胶柱色谱,Sephadex LH-20柱色谱和半制备型高效液相色谱等手段进行分离纯化,根据理化性质和波谱数据对化合物进行结构鉴定。结果从匙叶翼首草植物90%乙醇提取物的正丁醇萃取部分中分离得到22个化合物,分别鉴定为獐牙菜苷(1)、木犀草素(2)、3,4-二羟基肉桂酸甲酯(3)、songoroside A(4)、giganteaside D(5)、齐墩果酸-3-O-β-D-木吡喃糖基-(1→3)-α-L-鼠李吡喃糖基(1→2)-β-D-吡喃木糖苷(6)、hookeroside A(7)、prosapogenin Ax(8)、hookeroside B(9)、prosapogenin Bx(10)、hookeroside C(11)、hookeroside D(12)、马钱子苷(14)、齐墩果酸(15)、β-谷甾醇(16)、sylvestroside I(17)、triplostoside A(18)、sylvestroside IV dimethyl acetal(19)、(+)-1-羟基松香醇4′-O-β-D-吡喃葡萄糖苷(20)、(+)-1-羟基松香醇4″-O-β-D-吡喃葡萄糖苷(21)。结论化合物20,21为首次从翼花属植物中分离得到;1～3为首次从匙叶翼首草中分离得到。
引文
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[2] 吴春蕾,张志锋,刘圆.川续断科植物的研究进展[J].成都医学院学报,2009,4(1):66-71.
[3] TIAN J,WU F E,QIU M H,et al.Triterpenoidsaponins from Pterocephalushookeri[J].Phytochemistry,32(6):1535-1538.
[4] 张艺,李文军,孟宪丽,等.藏药翼首草化学成分的研究[J].成都中医药大学学报,2002,25(3):41-42,64.
[5] 田军,吴凤锷,邱明华,等.匙叶翼首花的化学成分[J].天然产物研究与开发,1999,12(1):35-38.
[6] JENSEN S R,LYSE-PETERSEN S E,NIELSEN B J.Novel Bisiridoidglucosides from dipsacussylvestris[J].Phytochemistry,1979,18(2):273-277.
[7] 梅文莉,倪伟,华燕,等.小叶红光的化学成分[J].天然产物研究与开发,2002,14(5):26-29.
[8] FUJIOKA T,FURUMI K,FUJII H,et al.Antiproliferative constituents from umbelliferae Plants.V.a new furanocoumarin and falcarindiol furanocoumarin ethers from the Root of Angelica japonica[J].Chem Pharm Bull,1999,47(1),96-100.
[9] 姚彩云,缪剑华,蒲祖怡,等.水忍冬藤茎化学成分的研究[J].中草药,2014,45(17):2431-2436.
[10] 付晓丽,张立伟,李青山,等.满山红化学成分的研究[J].中草药,2010,5(41):704-707.
[11] MAHATO S B,KUNDU A P.13C NMR Spectra of pentacyclictriterpenoids-a compilation and some salient features [J].Phytochemistry,1994,37(6):1517-1575.
[12] WU Y C,YIN Y J,LI Y M,et al.Secoiridoid/iridoid subtype bis-iridoids from pterocephalushookeri [J].Magn Reson Chem,2014,52(11),734-738.
[13] TIAN X Y,WANG Y H,LIU H Y,et al.On the chemical constituents of dipsacusasper [J].Chem Pharm Bull,2007,55(12):1677-1681.
[14] DEYAMA T,IKAWA T,KITAGAWA S,et al.The constituents of eucommiaulmoides OLIV.III.Isolation and structure of a new lignan glycoside [J].Chem Pharm Bull,1986,34(2):523-527.