血清降钙素原、C反应蛋白及血白细胞计数联合检测在颅脑手术后颅内感染中的预测价值
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摘要
目的探讨降钙素原(PCT)、C反应蛋白(CRP)、白细胞计数(WBC)联合检测在颅脑手术后颅内感染中的诊断价值。方法将我院收治的颅脑手术患者118例作为研究对象,按照术后是否出现感染将其分为感染组(53例)和未感染组(65例),检测比较两组患者血清PCT、CRP及WBC水平,通过ROC曲线下面积对患者颅内感染预测价值进行评价,并评价PCT、CRP及WBC的灵敏度及特异度。结果术后,感染组患者的PCT、CRP及WBC水平显著高于未感染组,两组差异有统计学意义(P<0.05);经ROC曲线分析表明,PCT、CRP、WBC联合检测预测效能高于任一指标单独检测。结论 PCT、CRP及WBC联合检测预测颅脑手术后颅内感染的灵敏度及特异度最高,具有较高的诊断价值。
Objective To study the diagnostic value of joint detection of procalcitonin(PCT),C-reactive protein(CRP) and white blood cell(WBC) in intracranial infection after craniocerebral surgery.Methods A total of 118 cases of craniocerebral surgery admitted from April 2015 to May 2018 in our hospital were divided into two groups:infection group(53 cases) and non-infection group(65 cases).The levels of PCT,CRP and WBC in both groups were detected and compared.The predicts value of intracranial infection was evaluated by the area under ROC curve,and the sensitivity and specificity of serum PCT,CRP and blood WBC were evaluated.Results After operation,the levels of PCT,CRP and WBC in the infection group were significantly higher than those in the non infected group.The difference between the two groups was statistically significant(P<0.05).The working characteristic curve(ROC) analysis showed that the predicts value of PCT,CRP and WBC combined detection was higher than any index.Conclusions The combined detection of PCT,CRP and WBC has the highest sensitivity and specificity in predicting intracranial infection after craniocerebral surgery,and has high diagnostic value.
Objective To study the diagnostic value of joint detection of procalcitonin(PCT),C-reactive protein(CRP) and white blood cell(WBC) in intracranial infection after craniocerebral surgery.Methods A total of 118 cases of craniocerebral surgery admitted from April 2015 to May 2018 in our hospital were divided into two groups:infection group(53 cases) and non-infection group(65 cases).The levels of PCT,CRP and WBC in both groups were detected and compared.The predicts value of intracranial infection was evaluated by the area under ROC curve,and the sensitivity and specificity of serum PCT,CRP and blood WBC were evaluated.Results After operation,the levels of PCT,CRP and WBC in the infection group were significantly higher than those in the non infected group.The difference between the two groups was statistically significant(P<0.05).The working characteristic curve(ROC) analysis showed that the predicts value of PCT,CRP and WBC combined detection was higher than any index.Conclusions The combined detection of PCT,CRP and WBC has the highest sensitivity and specificity in predicting intracranial infection after craniocerebral surgery,and has high diagnostic value.
引文
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[13]Gong Y,Fu G,Li B,et al.Comparison of the effects of minimally invasive percutaneous pedicle screws osteosynthesis and open surgery on repairing the pain,inflammation and recovery of thoracolumbar vertebra fracture[J].Exp Ther Med,2017,14(5):4091-4096.
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[2]Thakur SH,Joshi PC,Kelkar AB,et al.Unusual presentation of hydatid cyst-ruptured intraventricular hydatid[J].Indian J Radiol Imaging,2017,27(3):282-285.
[3]邢永国,孟伟英,张淑祥.神经外科开颅术后颅内感染诊治新进展[J].中华医院感染学杂志,2016,26(22):5268-5271.
[4]中华人民共和国卫生部.医院感染诊断标准(试行)[J].中华医学杂志,2001,81(5):314-320.
[5]罗波,唐晓平,马文超.颅脑手术后鲍曼不动杆菌颅内感染的临床分析[J].临床外科杂志,2015,23(8):601-603.
[6]Palanca BJA,Avidan MS,Mashour GA,et al.Human neural correlates of sevoflurane-induced unconsciousness[J].Br J Anaesth,2017,119(4):573-582.
[7]梁洪磊,刘启芬,刘增进.颅脑手术后颅内感染的危险因素分析[J].中国病原生物学杂志,2016,11(5):460-463.
[8]张卫群,祖向阳,李闯.炎性因子检测对颅内感染早期诊断的临床应用研究[J].中华医院感染学杂志,2016,26(16):3735-3737.
[9]Azuma Y,Sato I.The localization of calcitonin gene-related peptide in the human trigeminal ganglion and masseter muscle[J].Okajimas Folia Anat Jpn,2017,93(4):127-138.
[10]赵四军,赵明,徐欣.降钙素原和C-反应蛋白在老年颅脑手术后颅内感染中的诊断及预后价值分析[J].中华医院感染学杂志,2017,27(10):2267-2270.
[11]Shimazui T,Matsumura Y,Nakada TA,et al.Serum levels of interleukin-6 may predict organ dysfunction earlier than SOFA score[J].Acute Med Surg,2017,4(3):255-261.
[12]张守法,郭金荣,王利冉.血清C反应蛋白和降钙素原对颅内感染诊断的价值[J].中华医院感染学杂志,2016,26(14):3146-3148.
[13]Gong Y,Fu G,Li B,et al.Comparison of the effects of minimally invasive percutaneous pedicle screws osteosynthesis and open surgery on repairing the pain,inflammation and recovery of thoracolumbar vertebra fracture[J].Exp Ther Med,2017,14(5):4091-4096.
[14]乔潜林,白新学,刘海.脑脊液和血清中PCT与NSE及CRP检测在颅内感染诊断中的价值分析[J].中华医院感染学杂志,2017,27(11):2469-2472.