消旋山莨菪碱片与布洛芬治疗原发性痛经的疗效对比研究
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摘要
目的:比较消旋山莨菪碱片与布洛芬治疗原发性痛经的临床疗效。方法:回顾性选取2016年1月至2018年6月东莞市塘厦医院妇科门诊治疗的原发性痛经患者150例,依照不同给药方式分为观察组和对照组,每组75例。观察组患者应用消旋山莨菪碱片治疗,对照组患者应用布洛芬治疗,比较两组患者的药物控制成效、不良反应发生情况。结果:观察组患者药物控制总有效率为94.67%(71/75),明显高于对照组的85.33%(64/75),差异有统计学意义(P<0.05);观察组患者总不良反应发生率为5.33%(4/75),明显低于对照组的14.67%(11/75),差异有统计学意义(P<0.05)。结论:与布洛芬比较,消旋山莨菪碱片治疗原发性痛经更具优势,对布洛芬耐受性较差的患者可选用消旋山莨菪碱片替代治疗,可减少不良反应的发生。
OBJECTIVE: To compare the clinical efficacy of Raceanisodamine tablets and ibuprofen in treatment of primary dysmenorrhea. OBJECTIVE: 150 patients with primary dysmenorrhea admitted into gynecology department of Dongguan Tangxia Hospital from Jan. 2016 to Jun. 2018 were retrospectively extracted to be divided into observation group and control group via different administration route, with 75 cases in each. The observation group was given Raceanisodamine tablets, while the control group received ibuprofen. The drug control effectiveness, incidence of adverse drug reactions of two groups were compared. RESULTS: The total drug control effectiveness of observation group was 94.67%(71/75), signidicantly higher than that of control group(85.33%,64/75), with statistically significant difference(P<0.05). The total incidence of adverse drug reactions in observation group was 5.33%(4/75), significantly lower than that in control group(14.67%,11/75), with statistically significant difference(P<0.05). CONCLUSIONS: Compared with ibuprofen, Raceanisodamine tablets in treatment of primary dysmenorrhea have more advantages in treatment of primary dysmenorrhea. In patients with poor tolerance to ibuprofen, alternative treatment with Raceanisodamine tablets can be used to reduce the incidence of adverse drug reactions.
OBJECTIVE: To compare the clinical efficacy of Raceanisodamine tablets and ibuprofen in treatment of primary dysmenorrhea. OBJECTIVE: 150 patients with primary dysmenorrhea admitted into gynecology department of Dongguan Tangxia Hospital from Jan. 2016 to Jun. 2018 were retrospectively extracted to be divided into observation group and control group via different administration route, with 75 cases in each. The observation group was given Raceanisodamine tablets, while the control group received ibuprofen. The drug control effectiveness, incidence of adverse drug reactions of two groups were compared. RESULTS: The total drug control effectiveness of observation group was 94.67%(71/75), signidicantly higher than that of control group(85.33%,64/75), with statistically significant difference(P<0.05). The total incidence of adverse drug reactions in observation group was 5.33%(4/75), significantly lower than that in control group(14.67%,11/75), with statistically significant difference(P<0.05). CONCLUSIONS: Compared with ibuprofen, Raceanisodamine tablets in treatment of primary dysmenorrhea have more advantages in treatment of primary dysmenorrhea. In patients with poor tolerance to ibuprofen, alternative treatment with Raceanisodamine tablets can be used to reduce the incidence of adverse drug reactions.
引文
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[11] 刘炜,王霞,腾威,等.复方益母胶囊治疗原发性痛经的临床疗效及对子宫血流动力学的影响[J].陕西中医,2016,37(4):392-393.
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[13] 陈青,李军,谭会洁,等.盐酸消旋山莨菪碱注射液有关物质的研究[J].药物分析杂志,2014,13(5):865-868.
[14] 孙国政.消旋山莨菪碱片在原发性痛经患者中的疗效对比研究[J].按摩与康复医学,2018,9(11):36-37.
[2] 李蓉,乔杰.生殖内分泌疾病诊断与治疗[M].北京:北京大学医学出版社,2013:109-111.
[3] 崔丹凤,邵新军.姜枣汤配合布洛芬治疗原发性痛经[J].中国民间疗法,2016,24(7):24.
[4] 郭小红,慕丽红.郁芍汤联合布洛芬治疗原发性痛经的临床观察[J].中国妇幼保健,2016,31(3):634-635.
[5] 曲灵菊,王艳香.地屈孕酮与布洛芬对原发性痛经的治疗效果观察[J].中国继续医学教育,2016,8(7):169-170.
[6] 孙玉阳,纪宏宇,陈博,等.原发性痛经的发病机制及中医药治疗的研究进展[J].中国药师,2017,20(1):144-147.
[7] 杨方.使用益母草颗粒与布洛芬缓释胶囊治疗原发性痛经的效果对比[J].当代医药论丛,2017,15(11):102-103.
[8] 朱慧芳,王冬杰,郭静,等.自拟温经散寒中药组方联合布洛芬片及安宫黄体酮口服治疗血虚寒凝型原发性痛经的临床研究[J].实用妇科内分泌杂志:电子版,2016,3(15):3.
[9] 黄群,林辉,王南苏,等.痛经贴治疗原发性痛经寒凝血瘀证临床观察[J].光明中医,2016,31(2):174-176.
[10] 蒋雪霞,陈红,邓选碧,等.痛经方结合砭石疗法治疗寒凝血瘀型原发性痛经的临床研究[J].中医临床研究,2016,8(14):63-65.
[11] 刘炜,王霞,腾威,等.复方益母胶囊治疗原发性痛经的临床疗效及对子宫血流动力学的影响[J].陕西中医,2016,37(4):392-393.
[12] 林元理,黄宁,朱国链.布洛芬缓释胶囊联合生化汤治疗寒凝瘀血型痛经43例[J].中国中医药现代远程教育,2017,15(19):105-106.
[13] 陈青,李军,谭会洁,等.盐酸消旋山莨菪碱注射液有关物质的研究[J].药物分析杂志,2014,13(5):865-868.
[14] 孙国政.消旋山莨菪碱片在原发性痛经患者中的疗效对比研究[J].按摩与康复医学,2018,9(11):36-37.