基于细胞应激的核信号转导分析
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摘要
动物应激是以细胞应激为生理基础的,因此动物应激的基础研究应以细胞应激机理的部分理论为依据,而细胞核信号转导机理正是构成细胞应激理论的重要内容之一。从分子水平变化的角度综述了各细胞应激活性分子如Nur77、NF-κB、HSP70和RIP3等的出入细胞核机制,并以此为基础提出部分细胞应激核信号转导机制的猜想,为动物生产抗应激理论研究和预防提供一定思路。
The physiology of animal stress is based on cell stress,therefore,the mechanism of cell stress should belong to partly theory basis of animal stress,and the mechanism to nuclear signal transduction of cells is an important part in theory of cell stress.In this paper,it summarized the mechanism of bioactive molecules such as Nur77,NF-κB,HSP70,RIP3 and so on,which is in and out of nuclear in stress cell at the molecular level in this paper.As stated before,the conjecture on the partly mechanism to nuclear signal transduction of cells is proposed,which will provide some ideas in theory of the prevention research on stress during animal production.
The physiology of animal stress is based on cell stress,therefore,the mechanism of cell stress should belong to partly theory basis of animal stress,and the mechanism to nuclear signal transduction of cells is an important part in theory of cell stress.In this paper,it summarized the mechanism of bioactive molecules such as Nur77,NF-κB,HSP70,RIP3 and so on,which is in and out of nuclear in stress cell at the molecular level in this paper.As stated before,the conjecture on the partly mechanism to nuclear signal transduction of cells is proposed,which will provide some ideas in theory of the prevention research on stress during animal production.
引文
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[12]张端午.RIP3作为细胞凋亡与细胞因子相互转换的分子开关的发现和机理研究[D].厦门:厦门大学,2009:40.
[13]ZHANG D W,ZHENG M,ZHAO J,et al.Multiple death pathways in TNF-treated fibroblasts:RIP3-and RIP1-dependent and independent routes[J].Cell Res,2011,21(2):368-371.
[14]KARIN S K,ROSS H C,HANS O P,et al.Animal performance and stress:responses and tolerance limits at different levels of biological organization[J].Biological Reviews,2009,84:277-292.
[15]SHUAI Y,GUO J B,PENG S Q,et al.2007.Metallothionein inhibited DOX-inducedcardiac apoptosis in Mice[J].Sichuan Univ(Med Sci Edi),38(4):620-623.
[16]吴力专,罗佳捷,张彬,等.金属硫蛋白对奶牛体外脾淋巴细胞凋亡/坏死及线粒体膜电位的影响[J].畜牧兽医学报,2013,44(9):1475-1480.
[17]吴力专,罗佳捷,张彬,等.外源性金属硫蛋白对中国荷斯坦奶牛血淋巴细胞凋亡/坏死及线粒体膜电位的影响[J].草业学报,2013,22(4):205-211.
[2]ZHAGN Y,DU X,CHEN H,et al.C ytosporone B is an agonist for nuclear orphan receptor Nue77[J].Nat Chen Biol,2008,4(9):548-556.
[3]STASIK I,RAPAK A,KALAS W,et al.Ionomycin-induced apoptosis of thymocytes is independent of Nur77 NBRE or Nur RE binding,but is accompanied by Nur77 mitochondrial targeting[J].Biochim Biophys Acta,2007,1773(9):1483-1490.
[4]THOMPSON J,WINOTO A.During negative selection,Nur77 family proteins translocate to mitochondria where they associate with Bcl-2 and expose its proapoptotic BH3 domain[J].Exp,2008,74(4):1046-1058.
[5]余小挺,郑亦胡,郑飞云.孤儿受体Nur77与肿瘤的关系[J].肿瘤学杂质,2009,15(11):1043-1046.
[6]杜宝玲,张征宇,马宁芳.Bcl-2和核因子2κB在肝癌组织中的表达及其与临床预后的相关性[J].新医学,2009,40(11):373-378.
[7]刘奔,王帅,林涛,等.Bcl22过表达对多柔比星诱导的膀胱癌细胞凋亡和NF2κB活化影响的观察[J].中华肿瘤防治杂志,2009,16(11):941-844.
[8]DE Moissac D,MUSTAPHA S,GREENBERG A H,et al.Bcl-2 acti2vates t he t ranscription factor NF kappa B t hrough t he degrada2tion of t he cytoplasmic inhibitor Ikappa Balpha[J].J Biol Chem,1998,273(37):23946-23951.
[9]王慷慨,鄂顺梅,蒋磊,等.核定位信号在热休克蛋白70抑制氧化应激所致细胞核仁分离中的作用[J].生物化学与生物物理进展,2005,32(5):456-462.
[10]ZHANG Duan-Wu,SHAO Jing,LIN Juan,et al.RIP3,an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis[J].Science,2009,325(17):332-336.
[11]YANG Y,MA J,CHEN Y,et al.Nueleoeytoplasmic shuttling of receptor interacting protein3(Rip3):identification of novel nudea export and import signals in Rip3[J].J Biol Chem,2004,269:38820-38829.
[12]张端午.RIP3作为细胞凋亡与细胞因子相互转换的分子开关的发现和机理研究[D].厦门:厦门大学,2009:40.
[13]ZHANG D W,ZHENG M,ZHAO J,et al.Multiple death pathways in TNF-treated fibroblasts:RIP3-and RIP1-dependent and independent routes[J].Cell Res,2011,21(2):368-371.
[14]KARIN S K,ROSS H C,HANS O P,et al.Animal performance and stress:responses and tolerance limits at different levels of biological organization[J].Biological Reviews,2009,84:277-292.
[15]SHUAI Y,GUO J B,PENG S Q,et al.2007.Metallothionein inhibited DOX-inducedcardiac apoptosis in Mice[J].Sichuan Univ(Med Sci Edi),38(4):620-623.
[16]吴力专,罗佳捷,张彬,等.金属硫蛋白对奶牛体外脾淋巴细胞凋亡/坏死及线粒体膜电位的影响[J].畜牧兽医学报,2013,44(9):1475-1480.
[17]吴力专,罗佳捷,张彬,等.外源性金属硫蛋白对中国荷斯坦奶牛血淋巴细胞凋亡/坏死及线粒体膜电位的影响[J].草业学报,2013,22(4):205-211.